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NF2 encodes a protein that is similar to some members of the ERM (ezrin, radixin, moesin) family of proteins that are thought to link cytoskeletal components with proteins in the cell membrane. Additionally we are shipping Neurofibromin 2 Antibodies (165) and Neurofibromin 2 Kits (14) and many more products for this protein.
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Mutation of nf2 gene develops extrahepatic choledochal cysts in the common bile duct
loss of axonal contact following nerve injury results in merlin phosphorylation leading to increased p75(NTR (show NGFR Proteins)) expression.
Loss of Nf2 and Cdkn2a/b have synergistic effects with PDGF-B (show PDGFB Proteins) overexpression promoting meningioma malignant transformation.
Merlin 1 and 2 act as tumor suppressors and are required for optimal sperm maturation
Together our results uncover miRNAs as yet another negative mechanism controlling Merlin tumor suppressor functions.
Merlin and Ezrin (show EZR Proteins) are components of a mechanism where mechanical forces associated with cell junctions are transduced across the cell cortex via cortical actomyosin cytoskeleton to control lateral mobility and activity of epidermal growth factor receptor (show EGFR Proteins).
The study describe a novel NF2 mouse model recapitulating schwannoma phenotypes found in human patients where tumors develop in the cranial nerve VIII (show COX8A Proteins) and/or the spinal roots.
Nf2/Merlin controls spinal cord neural progenitor function in a Rac1/ErbB2 (show ERBB2 Proteins)-dependent manner.
Nf2-Yap signaling plays important roles in controlling the expansion of dorsal root ganglia progenitors and glia during DRG development
CD44 (show CD44 Proteins) cytoplasmic tail cleaved by RIP (show HRB Proteins) could release DCAF1 from merlin by competing for binding to the merlin FERM domain, which results in the inhibition of merlin-mediated suppression of tumorigenesis.
Findings indicate that merlin is sumoylated and that this post-translational modification is essential for tumor suppression.
Data suggest that, at least using the commercial antibodies used in this study, immunohistochemical staining for NF2 (neurofibromin 2), LATS2 (large tumor suppressor kinase 2), and YAP (show YAP1 Proteins)/TAZ (show TAZ Proteins) (nuclear translocation of complex of Yes-associated protein [YAP (show YAP1 Proteins)] with transcriptional coactivator with PDZ-binding motif (show WWTR1 Proteins) [TAZ (show TAZ Proteins)]) is not helpful for differential diagnosis of mesothelioma versus a benign proliferation.
The mortality of patients with NF2 diagnosed in more recent decades was lower than that of patients diagnosed earlier.
AMOTL1 Promotes Breast Cancer Progression and Is Antagonized by Merlin
homozygous deletions in CDKN2A and hemizygous loss of NF2 as detected by fluorescence in situ hybridization would confer a poor clinical outcome and may guide future treatment decisions for patients with peritoneal mesothelioma.
NF2/merlin inactivation augments mutant RAS signaling by promoting YAP (show YAP1 Proteins)/TEAD-driven transcription of oncogenic and wild-type RAS, resulting in greater MAPK (show MAPK1 Proteins) output and increased sensitivity to MEK (show MAP2K1 Proteins) inhibitors.
we demonstrate that NF2 negatively controls the invasiveness of Glioblastoma multiforme through YAP (show YAP1 Proteins)-dependent induction of CYR61/CCN1 (show CYR61 Proteins) and miR (show MLXIP Proteins)-296-3p.
angiomotin and Merlin respectively interface cortical actin filaments and core kinases in Hippo signaling
(Delta2-4)Merlin variant disrupts the normal function of Merlin and promotes hepatocellular carcinoma metastasis.
Stusies indicate that monosomy 22, which is often associated with mutations of the neurofibromin 2 (NF2) gene, has emerged as the most frequent alteration of meningiomas.
This gene encodes a protein that is similar to some members of the ERM (ezrin, radixin, moesin) family of proteins that are thought to link cytoskeletal components with proteins in the cell membrane. This gene product has been shown to interact with cell-surface proteins, proteins involved in cytoskeletal dynamics and proteins involved in regulating ion transport. This gene is expressed at high levels during embryonic development\; in adults, significant expression is found in Schwann cells, meningeal cells, lens and nerve. Mutations in this gene are associated with neurofibromatosis type II which is characterized by nervous system and skin tumors and ocular abnormalities. Two predominant isoforms and a number of minor isoforms are produced by alternatively spliced transcripts.
neurofibromin 2 (bilateral acoustic neuroma)
, neurofibromatosis 2
, neurofibromin 2
, moesin-ezrin-radixin-like protein
, moesin-ezrin-radixin like
, moesin-ezrin-radizin-like protein