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NGB encodes an oxygen-binding protein that is distantly related to members of the globin gene family. Additionally we are shipping Neuroglobin Kits (48) and Neuroglobin Proteins (24) and many more products for this protein.
Showing 10 out of 85 products:
Human Polyclonal Neuroglobin Primary Antibody for EIA, IHC (fro) - ABIN115511
Pesce, Bolognesi, Bocedi, Ascenzi, Dewilde, Moens, Hankeln, Burmester: Neuroglobin and cytoglobin. Fresh blood for the vertebrate globin family. in EMBO reports 2002
Show all 8 references for ABIN115511
Ngb expression is limited to the subpopulation of typ (show UBXN11 Antibodies)e I spiral ganglion cells, those which innervate inner hair cell (show UBXN11 Antibodies)s, while the subpopulation of type II spiral ganglion cells which innervate the outer hair cells do not express Ngb. The cochlear nuclei and superior olivary complex (SOC) also express considerable amounts of Ngb.
Ngb functions as a metabolic regulator and enhances cellular anabolism through the inhibition of AMPK (show PRKAA1 Antibodies) signaling.
Data show that the neuroglobin (Ngb) protein was downregulated in the retinal ganglion cells after optic nerve injury.
Overexpression of neuroglobin reduced sensorimotor deficits following TBI. An endogenous increase in neuroglobin expression occurs during the subacute period. Increasing neuroglobin expression during the acute period after TBI may improve recovery.
reflect lesser perturbations produced by acute inhalation of combustion smoke in the Ngb overexpressing mouse, suggesting that Ngb mitigates mitochondrial dysfunction and neurotoxicity and raises the threshold of smoke inhalation-induced brain injury
A critical role for neuroglobin is demonstrated via its differential interaction with phosphatase and tensin homolog (PTEN (show PTEN Antibodies)) and Akt (show AKT1 Antibodies) during neurite induction.
Neuroglobin overexpression resulted in a significant reduction in infarct volume 24 hours after brain ischemia.
Ngb overexpression can inhibit oxygen-glucose deprivation-induced mitochondria permeability transition opening in primary cultured mouse cortical
CREB (show CREB1 Antibodies) may also mediate transcriptional regulation of neuroglobin gene.
Ngb deficiency neither affected the level of Melanopsin (show OPN4 Antibodies) and Tyrosine Hydroxylase (show TH Antibodies) proteins nor the intactness of PACAP (show ADCYAP1 Antibodies)-positive retinohypothalamic projections in the suprachiasmatic nucleus.
Knockdown of GATA-2 (show GATA2 Antibodies) caused NGB (show GTPBP4 Antibodies) expression to drop dramatically, indicating GATA-2 (show GATA2 Antibodies) as an essential transcription factor for the activation of NGB (show GTPBP4 Antibodies) expression via binding to a novel distal regulatory element of NGB (show GTPBP4 Antibodies).
analysis of how the interaction of hydrogen sulfide (show SQRDL Antibodies) with human neuroglobin is muted (show MUTED Antibodies) by a distal ligand
NO oxidation kinetics at physiological NO concentrations. The use of a polarized electrode to efficiently interconvert the ferric (Fe(3+)) and ferrous (Fe(2+)) forms of an immobilized NGB (show GTPBP4 Antibodies) showed that the disulfide bridge both defines the kinetics of NO dioxygenase activity and regulates appearance of the free ferrous deoxy-NGB (show GTPBP4 Antibodies), which is the redox active form of the protein in contrast to oxy (show GCG Antibodies)-NGB (show GTPBP4 Antibodies).
Taken together, this work support the first evidence that Ngb (show GTPBP4 Antibodies) can be potentially used as a promising biomarker and target for novel treatment of human glioma
The cochlear nuclei and superior olivary complex (SOC (show UBXN11 Antibodies)) also express considerable amounts of Ngb (show GTPBP4 Antibodies). Within the human SOC (show UBXN11 Antibodies), many medial superior olive neurons, and scattered neurons in the LSO, were Ngb (show GTPBP4 Antibodies)-immunoreactive
Study characterized the presence of Ngb (show GTPBP4 Antibodies) in the human cochlea
Data show that the mean peak serum neuroglobin and Nogo-A concentrations were both significantly higher in patients with an unfavorable outcome at 6 months after traumatic brain injury (TBI).
Neuroglobin player role in estrogen receptor alpha (show ESR1 Antibodies)-positive cancer cell viability.
a mechanism for redox control of human Ngb (show GTPBP4 Antibodies) (hNgb) activity
17beta-estradiol-induced NGB (show GTPBP4 Antibodies) up-regulation could act as an oxidative stress sensor, which does not oppose to the pro-apoptotic 17beta-estradiol effect in ER beta (show ESR2 Antibodies)-containing colon cancer cells unless a rise of oxidative stress occurs.
Constitutive expression levels of neuroglobin in neonatal brain cells may explain mild neuronal injury after 60 min. of deep hypothermic circulatory arrest.
Ngb overexpression may have potential therapeutic benefits for both reducing secondary damages and improving the outcomes after traumatic spinal cord injury
The zebrafish Neuroglobin can catalyze the reduction of nitrite to nitric oxide with a broad range of reaction rate constants.
Data show that the neuroglobin (Ngb) protein was upregulated in the amacrine cells after optic nerve injury.
Chimeric Myoglobin (show MB Antibodies) has a cell-membrane-penetrating activity similar to zebrafish Ngb.
Neuroglobin appears to be associated with mitochondria-rich cell types and thus oxygen consumption rates, suggesting a myoglobin (show MB Antibodies)-like function of this protein in facilitated oxygen diffusion
both zebrafish and chimeric ZHHH Ngb can penetrate cell membranes in the absence of Chariot
This gene encodes an oxygen-binding protein that is distantly related to members of the globin gene family. It is highly conserved among other vertebrates. It is expressed in the central and peripheral nervous system where it may be involved in increasing oxygen availability and providing protection under hypoxic/ischemic conditions.
, GTP binding protein 3
, GTP-binding protein NGB
, Nucleolar GTP-binding protein 1 (Chronic renal failure gene protein) (GTP-binding protein NGB)
, chronic renal failure gene protein
, chronic renal failure protein
, nucleolar GTP-binding protein 1