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Neuronal Calcium Sensor 1 Proteins (NCS1)

NCS1 is a member of the neuronal calcium sensor gene family, which encode calcium-binding proteins expressed predominantly in neurons. Additionally we are shipping NCS1 Antibodies (99) and NCS1 Kits (5) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
NCS1 65153 P62168
NCS1 23413 P62166
NCS1 14299 Q8BNY6
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Top NCS1 Proteins at antibodies-online.com

Showing 10 out of 17 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 7 to 8 Days
$286.00
Details
HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
$333.33
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$2,451.17
Details
Yeast Xenopus laevis His tag   1 mg Log in to see 56 to 66 Days
$2,451.17
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$2,451.17
Details
Yeast Chicken His tag   1 mg Log in to see 56 to 66 Days
$2,451.17
Details
Yeast Caenorhabditis elegans His tag   1 mg Log in to see 56 to 66 Days
$2,454.83
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 3 to 4 Days
$322.14
Details

NCS1 Proteins by Origin and Source

Origin Expressed in Conjugate
Rat (Rattus)

Human , ,
,
Mouse (Murine)

Top referenced NCS1 Proteins

  1. Human NCS1 Protein expressed in Escherichia coli (E. coli) - ABIN666974 : Cox, Durussel, Comte, Nef, Nef, Lenz, Gundelfinger: Cation binding and conformational changes in VILIP and NCS-1, two neuron-specific calcium-binding proteins. in The Journal of biological chemistry 1995 (PubMed)
    Show all 2 references for ABIN666974

More Proteins for Neuronal Calcium Sensor 1 (NCS1) Interaction Partners

Human Neuronal Calcium Sensor 1 (NCS1) interaction partners

  1. Lithium normalizes gamma band oscillations mediated by P/Q-type calcium channels modulated by NCS-1.

  2. Study determined the salient features of the folding free-energy landscapes of the Mg2 (show MUC7 Proteins)+-bound and apo (show C9orf3 Proteins) states of NCS-1

  3. results reveal the important role of salt bridges on the structural properties of NCS-1 protein and that R102Q mutation disables the dynamic relocation of C-terminus, which may block the binding of NCS-1 protein to its receptors

  4. single-molecule optical tweezers were used to monitor misfolding reactions of the human neuronal calcium sensor-1.

  5. A strong liason was characterized between myristoylation and cryptic EF-1 (show EEF1D Proteins) in NCS-1.

  6. The functional link in substantia nigra dopamine neurons between Cav1.3 (show CACNA1D Proteins)- L-type-Ca2 (show CA2 Proteins)+ channels and D2-autoreceptor activity is an adaptive signalling network controlled by NCS-1.

  7. NCS1 has evolved a remarkable complex interdomain cooperativity and a fundamentally different folding mechanism compared to structurally related proteins.

  8. data suggest that genetic variants in the NCS-1 gene contribute to susceptibility of Cocaine Abuse in individuals of African descent.

  9. [review] Receptor interaction properties in schizophrenia are dependent upon NCS-1, a protein found to regulate the phosphorylation, trafficking, and signaling profile of the D2 dopamine receptor (D2R (show DRD2 Proteins)) in neurons.

  10. the C-terminal tail is important for regulating the conformational stability of NCS1 in Ca(2 (show CA2 Proteins)+)-activated state

Mouse (Murine) Neuronal Calcium Sensor 1 (NCS1) interaction partners

  1. These studies identify novel roles for NCS-1 in regulating activity-dependent striatal dopamine release and aspects of motivated behavior

  2. elevated expression of neuronal calcium sensor 1 (Ncs1) and dopamine type-2 receptors upon self-directed exploration, is reported.

  3. IGF-1 (show IGF1 Proteins) strengthens the interaction between NCS-1 and IP3R (show ITPR1 Proteins) in the process of regulation of nuclear Ca2 (show CA2 Proteins)+ signaling in cardiomyocytes.

  4. data implicate NCS-1 in exploratory activity, memory and mood-related behaviors, suggesting that NCS-1 gene ablation may result in phenotypic abnormalities associated with neuropsychiatric disorders

  5. NCS-1 transgene is upregulated in hypertrophic hearts, while hormone-induced hypertrophy is largely prevented in Ncs1-deficient hearts.

  6. NCS-1 is an accessory subunit of Kv4 (show KCNC1 Proteins)-encoded I(to,f) channels that functions to regulate I(to,f) density in the mammalian myocardium.

  7. PI 4-kinase functions to negatively regulate GLUT4 (show SLC2A4 Proteins) translocation through its interaction with NCS-1.

  8. NCS-1 should be considered an important potential Kv4 (show KCNC1 Proteins) regulatory subunit, particularly in the immature heart.

  9. During development, expression of NCS-1 in the olfactory epithelium was localized in the dendritic knobs and axons of olfactory sensory neurons. In the developing olfactory bulb, NCS-1 was expressed in the processes of mitral/tufted and granule cells.

Cow (Bovine) Neuronal Calcium Sensor 1 (NCS1) interaction partners

  1. C-terminal segment of NCS1 regulates reuptake of myristoyl group under Ca(2 (show CA2 Proteins)+)-free conditions and participates in organization of the target-binding pocket of the protein. We show putative role of NCS1 in photoreceptors as a modulator of GRK (show GRK4 Proteins) activity

  2. NCS-1-ARF1 (show ARF1 Proteins) interaction provides evidence for functional cross-talk between Ca(2 (show CA2 Proteins)+)-dependent and ARF-dependent pathways in TGN (show TG Proteins) to plasma membrane traffic

  3. Frequenin (BovFrq) native to the bovine hippocampus has been purified, sequenced for its 9 internal fragments, cloned, and studied.

Zebrafish Neuronal Calcium Sensor 1 (NCS1) interaction partners

  1. findings reveal a novel signalling pathway involved in development of the semicircular canal system, and suggest a previously unrecognized role for NCS-1 in mitochondrial function via its association with several mitochondrial proteins.

NCS1 Protein Profile

Protein Summary

This gene is a member of the neuronal calcium sensor gene family, which encode calcium-binding proteins expressed predominantly in neurons. The protein encoded by this gene regulates G protein-coupled receptor phosphorylation in a calcium-dependent manner and can substitute for calmodulin. The protein is associated with secretory granules and modulates synaptic transmission and synaptic plasticity. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with NCS1

  • frequenin-like (LOC100189965)
  • frequenin homolog (freq)
  • frequenin homolog (LOC100340886)
  • neuronal calcium sensor 1 (ncs1)
  • neuronal calcium sensor 1 (NCU04379)
  • neuronal calcium sensor 1 (MGYG_03475)
  • neuronal calcium sensor 1 (PGTG_09250)
  • neuronal calcium sensor 1 (Tsp_06748)
  • neuronal calcium sensor 1 (NCS1)
  • Neuronal calcium sensor 1 (ncs1)
  • neuronal calcium sensor 1 (Ncs1)
  • neuronal calcium sensor 1a (ncs1a)
  • Protein NCS-1 (ncs-1)
  • 9430075O15Rik protein
  • A730032G13Rik protein
  • AI836659 protein
  • FLUP protein
  • Freq protein
  • freqa protein
  • LOC100189965 protein
  • Mfreq protein
  • MGC75953 protein
  • NCS-1 protein
  • xfreq protein
  • zgc:63620 protein

Protein level used designations for NCS1

putative frequenin , frequenin homolog , frequenin-like protein , neuronal calcium sensor 1 , NCS-1 , Neuronal calcium sensor 1 , frequenin-like ubiquitous protein , neuronal calcium sensor-1 , frequenin , neuronal calcium sensor homologue , frequenin homolog a , ncs-1a , neuronal calcium sensor-1a

GENE ID SPECIES
100189965 Taeniopygia guttata
100303592 Saccoglossus kowalevskii
100340886 Oryctolagus cuniculus
394570 Xenopus (Silurana) tropicalis
3873635 Neurospora crassa OR74A
10028582 Arthroderma gypseum CBS 118893
10545012 Puccinia graminis f. sp. tritici CRL 75-36-700-3
10911856 Trichinella spiralis
100172236 Pongo abelii
100380555 Salmo salar
65153 Rattus norvegicus
23413 Homo sapiens
14299 Mus musculus
399297 Xenopus laevis
396336 Gallus gallus
526544 Bos taurus
393437 Danio rerio
180448 Caenorhabditis elegans
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