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NCS1 is a member of the neuronal calcium sensor gene family, which encode calcium-binding proteins expressed predominantly in neurons. Additionally we are shipping NCS1 Antibodies (82) and NCS1 Proteins (16) and many more products for this protein.
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Results show that although NCS-1 Var2mRNA can be detected, protein expression was not detectable. When overexpressed in cell lines NCS-1 Var2 appears to be folded properly, yet it has a lower calcium affinity. Because most NCS-1 binding to its protein partners requires calcium binding, it is unlikely that NCS-1 Var2 would play a major regulatory role in cells.
structural and dynamical response of NCS-1 protein to elevated temperature may be one of its intrinsic functional properties
Lithium normalizes gamma band oscillations mediated by P/Q-type calcium channels modulated by NCS-1.
Study determined the salient features of the folding free-energy landscapes of the Mg2 (show MUC7 ELISA Kits)+-bound and apo (show C9orf3 ELISA Kits) states of NCS-1
results reveal the important role of salt bridges on the structural properties of NCS-1 protein and that R102Q mutation disables the dynamic relocation of C-terminus, which may block the binding of NCS-1 protein to its receptors
single-molecule optical tweezers were used to monitor misfolding reactions of the human neuronal calcium sensor-1.
A strong liason was characterized between myristoylation and cryptic EF-1 (show EEF1D ELISA Kits) in NCS-1.
The functional link in substantia nigra dopamine neurons between Cav1.3 (show CACNA1D ELISA Kits)- L-type-Ca2 (show CA2 ELISA Kits)+ channels and D2-autoreceptor activity is an adaptive signalling network controlled by NCS-1.
NCS1 has evolved a remarkable complex interdomain cooperativity and a fundamentally different folding mechanism compared to structurally related proteins.
data suggest that genetic variants in the NCS-1 gene contribute to susceptibility of Cocaine Abuse in individuals of African descent.
Phosphorylation of CaMKII (show CAMK2G ELISA Kits)-alpha, known to trigger long-term potentiation and increase BDNF (show BDNF ELISA Kits) levels, was significantly reduced in the Ncs1-/- mouse brain. Further, electric potential stimulation, which increases the levels of BDNF (show BDNF ELISA Kits) and promotes spatial learning, significantly increased the levels of NCS-1 concomitant with phosphorylated CaMKII (show CAMK2G ELISA Kits)-alpha in the hippocampus; suggesting a close relationship between NCS-1 and CaM...
these data demonstrate that NCS-1 contributes to stress tolerance in cardiomyocytes at least in part by activating certain Ca(2 (show CA2 ELISA Kits)+)-dependent survival pathways that promote mitochondrial biosynthesis/function and detoxification pathways.
These studies identify novel roles for NCS-1 in regulating activity-dependent striatal dopamine release and aspects of motivated behavior
elevated expression of neuronal calcium sensor 1 (Ncs1) and dopamine type-2 receptors upon self-directed exploration, is reported.
IGF-1 (show IGF1 ELISA Kits) strengthens the interaction between NCS-1 and IP3R (show ITPR1 ELISA Kits) in the process of regulation of nuclear Ca2 (show CA2 ELISA Kits)+ signaling in cardiomyocytes.
data implicate NCS-1 in exploratory activity, memory and mood-related behaviors, suggesting that NCS-1 gene ablation may result in phenotypic abnormalities associated with neuropsychiatric disorders
NCS-1 transgene is upregulated in hypertrophic hearts, while hormone-induced hypertrophy is largely prevented in Ncs1-deficient hearts.
NCS-1 is an accessory subunit of Kv4 (show KCNC1 ELISA Kits)-encoded I(to,f) channels that functions to regulate I(to,f) density in the mammalian myocardium.
PI 4-kinase functions to negatively regulate GLUT4 (show SLC2A4 ELISA Kits) translocation through its interaction with NCS-1.
NCS-1 should be considered an important potential Kv4 (show KCNC1 ELISA Kits) regulatory subunit, particularly in the immature heart.
C-terminal segment of NCS1 regulates reuptake of myristoyl group under Ca(2 (show CA2 ELISA Kits)+)-free conditions and participates in organization of the target-binding pocket of the protein. We show putative role of NCS1 in photoreceptors as a modulator of GRK (show GRK4 ELISA Kits) activity
NCS-1-ARF1 (show ARF1 ELISA Kits) interaction provides evidence for functional cross-talk between Ca(2 (show CA2 ELISA Kits)+)-dependent and ARF-dependent pathways in TGN (show TG ELISA Kits) to plasma membrane traffic
Frequenin (BovFrq) native to the bovine hippocampus has been purified, sequenced for its 9 internal fragments, cloned, and studied.
findings reveal a novel signalling pathway involved in development of the semicircular canal system, and suggest a previously unrecognized role for NCS-1 in mitochondrial function via its association with several mitochondrial proteins.
This gene is a member of the neuronal calcium sensor gene family, which encode calcium-binding proteins expressed predominantly in neurons. The protein encoded by this gene regulates G protein-coupled receptor phosphorylation in a calcium-dependent manner and can substitute for calmodulin. The protein is associated with secretory granules and modulates synaptic transmission and synaptic plasticity. Multiple transcript variants encoding different isoforms have been found for this gene.
, frequenin homolog
, frequenin-like protein
, neuronal calcium sensor 1
, Neuronal calcium sensor 1
, frequenin-like ubiquitous protein
, neuronal calcium sensor-1
, neuronal calcium sensor homologue
, frequenin homolog a
, neuronal calcium sensor-1a