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Neuronal PAS Domain Protein 2 Proteins (NPAS2)

The protein encoded by NPAS2 is a member of the basic helix-loop-helix (bHLH)-PAS family of transcription factors. Additionally we are shipping Neuronal PAS Domain Protein 2 Antibodies (55) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
NPAS2 4862 Q99743
NPAS2 18143 P97460
Rat NPAS2 NPAS2 316351  
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Top Neuronal PAS Domain Protein 2 Proteins at antibodies-online.com

Showing 3 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
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HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
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HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
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NPAS2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

More Proteins for Neuronal PAS Domain Protein 2 (NPAS2) Interaction Partners

Human Neuronal PAS Domain Protein 2 (NPAS2) interaction partners

  1. CLOCK, ARNTL (show ARNTL Proteins), and NPAS2 gene polymorphisms may have a role in seasonal variations in mood and behavior

  2. Genetic variations in NPAS2 might be a biomarker for a seasonal pattern in bipolar disorders.

  3. With whole-exome sequencing a novel mutation in NPAS2 was identified in a Turkish family with nonobstructive azoospermia.

  4. NPAS2 rs2305160 polymorphism does not appear to have any association with risk of chronic lymphocytic leukemia in our Pakistani population.

  5. distributions of allelic, genotypic, and haplotypic variants of NPAS2 (rs2305160 and rs6725296) were not significantly different between schizophrenic patients with and without RLS

  6. Two single nucleotide polymorphisms in RORA (show RORA Proteins) were associated with breast cancer in the whole sample and among postmenopausal women, and we also reported an association with CLOCK, RORA (show RORA Proteins), and NPAS2 in the analyses at the gene level

  7. Functional rs1053096 and rs2305160 polymorphisms in the NPAS2 gene are associated with overall survival in transcatheter arterial chemoembolization-treated hepatocellular carcinoma patients.

  8. NPAS2, functioned as a potential tumor suppressor gene, could serve as a promising target and potential prognostic indicator for colorectal cancer.

  9. Variants in NPAS2 have been associated with seasonality and seasonal affective disorder, phenotypes that could reflect circadian rhythm disruption.

  10. Genetic variants of NPAS2 associate with seasonal affective disorder or winter depression.

Mouse (Murine) Neuronal PAS Domain Protein 2 (NPAS2) interaction partners

  1. In CLOCK-deficient fibroblasts, knockdown of Npas2 leads to arrhythmicity, suggesting that NPAS2 can compensate for loss of CLOCK in peripheral cells as well as in suprachiasmatic nucleus.

  2. Study identified a unique role for Npas2 in the regulation of cocaine reward and dopamine Drd3 (show DRD3 Proteins) receptor expression

  3. In the absence of NADPH (show FDXR Proteins), a change in pH from 6.5 to 8.0 decreased the KD(app (show APP Proteins)) value of the E-box from 125 to 22 nM, with an 8-fold increase in the maximal level of DNA binding for the NPAS2/BMAL1 (show ARNTL Proteins) heterodimer.

  4. Shp (show LAMC1 Proteins) and Npas2 crosstalk is essential to maintain hepatic lipid homeostasis.

  5. Dysregulation of Npas2 leads to altered metabolic pathways in a murine knockout model.

  6. BMAL1 (show ARNTL Proteins) in a complex with CLOCK or NPAS2 regulates cerebral redox homeostasis and connects impaired clock gene function to neurodegeneration.

  7. Npas2 shows circadian expression in retinal ganglion cells in mice.And Contrast sensitivity is similarly reduced in Npas2-/- mice.

  8. NPAS2 containing the N-terminal 61 residues forms a heterodimer with aryl hydrocarbon receptor nuclear translocator-like (show ARNTL Proteins) protein (BMAL1 (show ARNTL Proteins)) to bind DNA; NAD(P)H (show NQO1 Proteins) enhances the binding activity.

  9. DNA-binding of NPAS2 and BMAL1 (show ARNTL Proteins) to Per2 (show PER2 Proteins) was also decreased by SD, although SD is known to increase Per2 (show PER2 Proteins) expression in the cortex. DNA-binding to Per1 and Cry1 (show CRY1 Proteins) was not affected by SD

  10. NPAS2 deletion produced significant impairment in the ability of the knockout mice to maintain body weight during restricted feeding and overnight food deprivation.

Neuronal PAS Domain Protein 2 (NPAS2) Protein Profile

Protein Summary

The protein encoded by this gene is a member of the basic helix-loop-helix (bHLH)-PAS family of transcription factors. A similar mouse protein may play a regulatory role in the acquisition of specific types of memory. It also may function as a part of a molecular clock operative in the mammalian forebrain.

Gene names and symbols associated with NPAS2

  • neuronal PAS domain protein 2 (NPAS2)
  • neuronal PAS domain protein 2 (LOC100223816)
  • neuronal PAS domain protein 2 (npas2)
  • neuronal PAS domain protein 2 (Npas2)
  • bHLHe9 protein
  • MOP4 protein
  • NPAS2 protein
  • PASD4 protein
  • zfCLOCK2 protein

Protein level used designations for NPAS2

neuronal PAS domain protein 2 , neuronal PAS domain-containing protein 2-like , bHLH-PAS clock protein , bHLH-PAS transcription factor MOP4 , member of PAS protein 4 , neuronal PAS domain-containing protein 2 , neuronal PAS2 , PAS domain-containing protein 4 , basic-helix-loop-helix-PAS protein MOP4 , class E basic helix-loop-helix protein 9 , member of PAS superfamily 4

GENE ID SPECIES
100477316 Ailuropoda melanoleuca
459449 Pan troglodytes
474552 Canis lupus familiaris
100223816 Taeniopygia guttata
100415159 Callithrix jacchus
100433101 Pongo abelii
100486786 Xenopus (Silurana) tropicalis
100521893 Sus scrofa
100547638 Meleagris gallopavo
100580772 Nomascus leucogenys
352934 Danio rerio
395433 Gallus gallus
4862 Homo sapiens
614049 Bos taurus
18143 Mus musculus
316351 Rattus norvegicus
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