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NPAS3 encodes a member of the basic helix-loop-helix and PAS domain-containing family of transcription factors. Additionally we are shipping NPAS3 Antibodies (36) and and many more products for this protein.
Authors hypothesize that any nucleotide variant at the NPAS3 HAEs may lead to altered susceptibility to schizophrenia.
Identification of NPAS3-V304I helps strengthen the hypothesis that NPAS3 is involved in schizophrenia pathogenesis
The accelerated non-coding region 2xHAR142 of NPAS3 behaves as a developmental enhancer in the forebrain of transgenic mice.
Results indicate that the high density of HAEs present in the human NPAS3 locus could have modified the spatiotemporal expression pattern of NPAS3 in the developing human brain and, therefore, contributed to human brain evolution.
During human postnatal cortical development, there was decreased NPAS3 mRNA yet increased NPAS3 protein expression, suggesting the involvement of posttranscriptional regulation, which results show is modified by miR-17.
In a HEK293 cell line over-expressing NPAS3, transcriptional targets varied with to circadian rhythm context & C-terminal deletion. NPAS3 contributes to neurodevelopmental transcription factor networks & the regulation of brain glucose metabolism.
Loss of NPAS3 is associated with the progression of Astrocytomas.
report of immunohistochemical findings on NPAS3 protein expression in the developing human fetal brain during the three trimesters (10-41 weeks) of gestational development
This study identification of potentially defective NPAS3 variants supports recent studies that implicate perturbations in NPAS3 pathways in impaired neurogenesis and psychosis.
haploinsufficiency of NPAS3 contributes to the cause of schizophrenia
Most NPAS3 immunofluorescence originated in the subgranular zone of the dentate gyrus with immunopositive processes radiating into the granule cell layer proper. Npas3 acts during neuronal maturation/differentiation.
a regulatory program controlled in inhibitory interneurons by the NPAS1 (show NPAS1 ELISA Kits) and NPAS3 transcription factors may be either substantively or tangentially relevant to psychosis
Npas3-/- mice are deficient in expression of hippocampal FGF receptor (show FGFR2 ELISA Kits) subtype 1 mRNA.
our observations indicate an important role for Npas3 in controlling normal brain development and neurosignaling pathways
NPAS3 is a trachealess homolog critical for lung development and homeostasis.
This gene encodes a member of the basic helix-loop-helix and PAS domain-containing family of transcription factors. The encoded protein is localized to the nucleus and may regulate genes involved in neurogenesis. Chromosomal abnormalities that affect the coding potential of this gene are associated with schizophrenia and mental retardation. Alternate splicing results in multiple transcript variants.
neuronal PAS domain protein 3
, basic-helix-loop-helix-PAS protein
, neuronal PAS domain-containing protein 3-like
, PAS domain-containing protein 6
, basic-helix-loop-helix-PAS protein MOP6
, class E basic helix-loop-helix protein 12
, member of PAS protein 6
, neuronal PAS domain-containing protein 3
, neuronal PAS3