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NXF is a member of the basic helix-loop-helix-PER (MIM 602260)-ARNT (MIM 126110)-SIM (see SIM2\; MIM 600892) (bHLH-PAS) class of transcriptional regulators, which are involved in a wide range of physiologic and developmental events (Ooe et al., 2004 [PubMed 14701734]).[supplied by OMIM, Mar 2008].. Additionally we are shipping NPAS4 Antibodies (55) and NPAS4 Kits (2) and many more products for this protein.
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This review summarizes the current knowledge of the roles that Npas4 may play in neuroinflammation and ischemia. [review]
we provide the first evidence that Npas4 is expressed during embryonic development and that it may have a developmental role that is unrelated to its function in the adult brain
These results provide insight into the mechanisms of NPAS4/ARNT (show ARNT Proteins) dimerisation and transcriptional activation.
a novel NXF signaling system on neural gene promoter may be a molecular target of the adverse effects of Sim2 (show SIM2 Proteins) in the mental retardation of Down's syndrome
beta cell cytotoxicity of the calcineurin inhibitor (show RCAN1 Proteins) and immunosuppressant tacrolimus (FK-506) was prevented by Npas4 overexpression.
Results suggest that transcription of the Npas4 gene is downregulated by stress through DNA methylation (show HELLS Proteins) of its promoter
induction of Npas4 identifies the area influenced by cortical spreading depression propagation.
Cortex activation by sensory conditioning was found to upregulate the expression of both Npas4 and c-Fos.
Data showed that differential levels of Npas4 expression in the brain may regulate anxiety, depression and cognition related disorders.
Npas4 regulates Mdm2 (show MDM2 Proteins) expression during dendritic spine development in newborn olfactory bulb after sensory experience.
Study describes a transcriptional program that is induced by neuronal activity in inhibitory neurons; while neuronal activity induces expression of early-response transcription factors such as Npas4 in both excitatory and inhibitory neurons, Npas4 activates distinct programs of late-response genes in inhibitory and excitatory neurons.
Our results reveal REST and microRNA dependent mechanisms that restrict NPAS4 expression to the brain
sensory stimuli, by inducing NPAS4 and its target genes, differentially control spatial features of neuronal inhibition in a way that restricts the output of the neuron while creating a dendritic environment that is permissive for plasticity
NXF is a member of the basic helix-loop-helix-PER (MIM 602260)-ARNT (MIM 126110)-SIM (see SIM2\; MIM 600892) (bHLH-PAS) class of transcriptional regulators, which are involved in a wide range of physiologic and developmental events (Ooe et al., 2004
neuronal PAS domain protein 4
, HLH-PAS transcription factor NXF
, neuronal PAS domain-containing protein 4
, neuronal PAS domain-containing protein 4-like
, PAS domain-containing protein 10
, class E basic helix-loop-helix protein 79
, neuronal PAS4
, bHLH PAS type transcription factor NXF
, bHLH-PAS type transcription factor NXF
, limbic-enhanced PAS protein