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Neuronal PAS Domain Protein 4 Proteins (NPAS4)

NXF is a member of the basic helix-loop-helix-PER (MIM 602260)-ARNT (MIM 126110)-SIM (see SIM2\; MIM 600892) (bHLH-PAS) class of transcriptional regulators, which are involved in a wide range of physiologic and developmental events (Ooe et al., 2004 [PubMed 14701734]).[supplied by OMIM, Mar 2008].. Additionally we are shipping NPAS4 Antibodies (55) and NPAS4 Kits (2) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
NPAS4 266743 Q8IUM7
NPAS4 266734 Q8CJH6
NPAS4 225872 Q8BGD7
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Top NPAS4 Proteins at antibodies-online.com

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   5 applications Log in to see 1 to 2 Days
$312.71
Details

NPAS4 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Rat (Rattus)
Mouse (Murine)

More Proteins for Neuronal PAS Domain Protein 4 (NPAS4) Interaction Partners

Human Neuronal PAS Domain Protein 4 (NPAS4) interaction partners

  1. This review summarizes the current knowledge of the roles that Npas4 may play in neuroinflammation and ischemia. [review]

  2. we provide the first evidence that Npas4 is expressed during embryonic development and that it may have a developmental role that is unrelated to its function in the adult brain

  3. These results provide insight into the mechanisms of NPAS4/ARNT (show ARNT Proteins) dimerisation and transcriptional activation.

  4. a novel NXF signaling system on neural gene promoter may be a molecular target of the adverse effects of Sim2 (show SIM2 Proteins) in the mental retardation of Down's syndrome

Mouse (Murine) Neuronal PAS Domain Protein 4 (NPAS4) interaction partners

  1. beta cell cytotoxicity of the calcineurin inhibitor (show RCAN1 Proteins) and immunosuppressant tacrolimus (FK-506) was prevented by Npas4 overexpression.

  2. Results suggest that transcription of the Npas4 gene is downregulated by stress through DNA methylation (show HELLS Proteins) of its promoter

  3. induction of Npas4 identifies the area influenced by cortical spreading depression propagation.

  4. Cortex activation by sensory conditioning was found to upregulate the expression of both Npas4 and c-Fos.

  5. Data showed that differential levels of Npas4 expression in the brain may regulate anxiety, depression and cognition related disorders.

  6. Npas4 regulates Mdm2 (show MDM2 Proteins) expression during dendritic spine development in newborn olfactory bulb after sensory experience.

  7. we provide the first evidence that Npas4 is expressed during embryonic development and that it may have a developmental role that is unrelated to its function in the adult brain

  8. Study describes a transcriptional program that is induced by neuronal activity in inhibitory neurons; while neuronal activity induces expression of early-response transcription factors such as Npas4 in both excitatory and inhibitory neurons, Npas4 activates distinct programs of late-response genes in inhibitory and excitatory neurons.

  9. Our results reveal REST and microRNA dependent mechanisms that restrict NPAS4 expression to the brain

  10. sensory stimuli, by inducing NPAS4 and its target genes, differentially control spatial features of neuronal inhibition in a way that restricts the output of the neuron while creating a dendritic environment that is permissive for plasticity

NPAS4 Protein Profile

Protein Summary

NXF is a member of the basic helix-loop-helix-PER (MIM 602260)-ARNT (MIM 126110)-SIM (see SIM2\; MIM 600892) (bHLH-PAS) class of transcriptional regulators, which are involved in a wide range of physiologic and developmental events (Ooe et al., 2004

Gene names and symbols associated with NPAS4

  • neuronal PAS domain protein 4 (NPAS4)
  • neuronal PAS domain protein 4 (npas4)
  • neuronal PAS domain-containing protein 4 (Tsp_02837)
  • neuronal PAS domain protein 4 (Npas4)
  • neuronal PAS domain protein 4a (npas4a)
  • bHLHe79 protein
  • LE-PAS protein
  • MGC146621 protein
  • npas4 protein
  • Nxf protein
  • PASD10 protein
  • wu:fj52d04 protein
  • zgc:136764 protein

Protein level used designations for NPAS4

neuronal PAS domain protein 4 , HLH-PAS transcription factor NXF , neuronal PAS domain-containing protein 4 , neuronal PAS domain-containing protein 4-like , PAS domain-containing protein 10 , class E basic helix-loop-helix protein 79 , neuronal PAS4 , bHLH PAS type transcription factor NXF , bHLH-PAS type transcription factor NXF , limbic-enhanced PAS protein

GENE ID SPECIES
466676 Pan troglodytes
714161 Macaca mulatta
780368 Xenopus (Silurana) tropicalis
10899621 Trichinella spiralis
100029618 Monodelphis domestica
100052469 Equus caballus
100359105 Oryctolagus cuniculus
100397060 Callithrix jacchus
100442686 Pongo abelii
100481488 Ailuropoda melanoleuca
100505459 Ovis aries
100520174 Sus scrofa
100593820 Nomascus leucogenys
266743 Homo sapiens
266734 Rattus norvegicus
225872 Mus musculus
483711 Canis lupus familiaris
781497 Bos taurus
724016 Danio rerio
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