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NPTX2 encodes a member of the family of neuronal petraxins, synaptic proteins that are related to C-reactive protein. Additionally we are shipping Neuronal Pentraxin II Antibodies (70) and Neuronal Pentraxin II Kits (11) and many more products for this protein.
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Early postnatal NPTX2(-/-)/NPTXR (show NPTXR Proteins)(-/-) mice exhibit delayed circuit maturation with a prolonged critical period permissive for giant depolarizing potentials
Nptx2 contributes to the development of L-DOPA-induced dyskinesia.
These findings suggest that Narp, and perhaps other neuronal pentraxins, also regulate inflammation in the nervous system.
Narp KO mice do not have abnormal reactivity to novelty but show deficits in adapting behavior to reflect the updated value of a stimulus.
the results of this study indicated that Narp released from mPFC neurons plays a key role in mediating synaptic changes underlying instrumental reinforcer devaluation.
Narp prominently accumulated at excitatory synapses on parvalbumin (show PVALB Proteins)-expressing interneurons, propose that Narp recruits AMPARs at excitatory synapses onto interneurons to rebalance network excitation/inhibition dynamics following increased circuit activity
data indicate that the loss of NP1 (show NPX1 Proteins)/2 disrupts several aspects of retinogeniculate development including the initial establishment of AMPAR transmission and the subsequent elimination of inappropriate circuit connections
Neuronal pentraxin 1 (show NPX1 Proteins) and 2 are necessary for early synaptic refinements in mammalian retina and dorsal lateral geniculate nucleus. May exert their effects through mechanisms paralleling known role of short pentraxins outside the CNS. (Pentraxin 1 (show CRP Proteins) and 2)
these findings provide compelling evidence that Narp is secreted from vasopressin (show AVP Proteins) neurons in an activity-dependent fashion
findings indicate that Narp plays a selective role in extinction of morphine-induced place preference, possibly by its effects on AMPA (show GRIA3 Proteins) receptor trafficking
Decreased NPTX2 expression in rectal adenocarcinomas is associated with improved response to neoadjuvant chemoradiation and improved prognosis.
we show that NPTX2 is a marker of poor prognosis for neuroblastoma (show ARHGEF16 Proteins) patients.
NPTX2 is overexpressed specifically in ccRCC primary tumors.
NPTX2 repressed NF-kappaB (show NFKB1 Proteins) activity by inhibiting AKT (show AKT1 Proteins) through a p53 (show TP53 Proteins)-PTEN-dependent pathway, thus explaining the hypermethylation and downregulation of NPTX2 in NF-kappaB (show NFKB1 Proteins)-activated high-risk glioblastomas.
Promoter methylation of NPTX2 is associated with glioblastoma.
Detection of aberrant methylation of NPTX2 in pure pancreatic juice samples could be useful as a molecular marker to discriminate between patients with malignant and benign disease of the pancreas
The visual cortex of NARP-deficient transgenic mice is hyperexcitable and unable to express ocular dominance, although many aspects of visual function are unimpaired.
This study showed that the NPTX2 protein is down-regulated in human primary pancreatic cancers and in pancreatic cancer cell lines.
This study demonistrated that childhood-onset mood disorders and suicide attempt association between HOMER1 (show HOMER1 Proteins) rs2290639 and between NPTX2 markers rs705315 and rs1681248.
Demonstrate for the first time that NARP mutation significantly enhances apoptotic death as a result of three distinct lethal mitochondrial apoptotic insults including oxidative, Ca(2 (show CA2 Proteins)+), and lipid stress.
This gene encodes a member of the family of neuronal petraxins, synaptic proteins that are related to C-reactive protein. This protein is involved in excitatory synapse formation. It also plays a role in clustering of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptors at established synapses, resulting in non-apoptotic cell death of dopaminergic nerve cells. Up-regulation of this gene in Parkinson disease (PD) tissues suggests that the protein may be involved in the pathology of PD.
neuronal pentraxin II
, Neuronal activity regulated pentraxin
, neuro activity regulated petaxin
, neuronal pentraxin-2
, acrosomal pentaxin-like protein p50
, neuronal activity-regulated pentaxin
, neuronal activity-regulated pentraxin
, neuronal pentraxin 2