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Neuronal Pentraxin II Proteins (NPTX2)

NPTX2 encodes a member of the family of neuronal petraxins, synaptic proteins that are related to C-reactive protein. Additionally we are shipping Neuronal Pentraxin II Antibodies (65) and Neuronal Pentraxin II Kits (11) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
NPTX2 25487  
NPTX2 53324 O70340
NPTX2 4885 P47972
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Top Neuronal Pentraxin II Proteins at antibodies-online.com

Showing 8 out of 8 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Human His tag,T7 tag 100 μg Log in to see 11 to 13 Days
$728.20
Details
Yeast Guinea Pig His tag   1 mg Log in to see 56 to 66 Days
$3,138.67
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$3,162.50
Details
HOST_Sf-9 Cells Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$460.85
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

NPTX2 Proteins by Origin and Source

Origin Expressed in Conjugate
Rat (Rattus)

Mouse (Murine)

Human , , ,
, ,

More Proteins for Neuronal Pentraxin II (NPTX2) Interaction Partners

Mouse (Murine) Neuronal Pentraxin II (NPTX2) interaction partners

  1. Early postnatal NPTX2(-/-)/NPTXR (show NPTXR Proteins)(-/-) mice exhibit delayed circuit maturation with a prolonged critical period permissive for giant depolarizing potentials

  2. Nptx2 contributes to the development of L-DOPA-induced dyskinesia.

  3. These findings suggest that Narp, and perhaps other neuronal pentraxins, also regulate inflammation in the nervous system.

  4. Narp KO mice do not have abnormal reactivity to novelty but show deficits in adapting behavior to reflect the updated value of a stimulus.

  5. the results of this study indicated that Narp released from mPFC neurons plays a key role in mediating synaptic changes underlying instrumental reinforcer devaluation.

  6. Narp prominently accumulated at excitatory synapses on parvalbumin (show PVALB Proteins)-expressing interneurons, propose that Narp recruits AMPARs at excitatory synapses onto interneurons to rebalance network excitation/inhibition dynamics following increased circuit activity

  7. data indicate that the loss of NP1 (show NPX1 Proteins)/2 disrupts several aspects of retinogeniculate development including the initial establishment of AMPAR transmission and the subsequent elimination of inappropriate circuit connections

  8. Neuronal pentraxin 1 (show NPX1 Proteins) and 2 are necessary for early synaptic refinements in mammalian retina and dorsal lateral geniculate nucleus. May exert their effects through mechanisms paralleling known role of short pentraxins outside the CNS. (Pentraxin 1 (show CRP Proteins) and 2)

  9. these findings provide compelling evidence that Narp is secreted from vasopressin (show AVP Proteins) neurons in an activity-dependent fashion

  10. findings indicate that Narp plays a selective role in extinction of morphine-induced place preference, possibly by its effects on AMPA (show GRIA3 Proteins) receptor trafficking

Human Neuronal Pentraxin II (NPTX2) interaction partners

  1. Decreased NPTX2 expression in rectal adenocarcinomas is associated with improved response to neoadjuvant chemoradiation and improved prognosis.

  2. we show that NPTX2 is a marker of poor prognosis for neuroblastoma (show ARHGEF16 Proteins) patients.

  3. NPTX2 is overexpressed specifically in ccRCC primary tumors.

  4. NPTX2 repressed NF-kappaB (show NFKB1 Proteins) activity by inhibiting AKT (show AKT1 Proteins) through a p53 (show TP53 Proteins)-PTEN-dependent pathway, thus explaining the hypermethylation and downregulation of NPTX2 in NF-kappaB (show NFKB1 Proteins)-activated high-risk glioblastomas.

  5. Promoter methylation of NPTX2 is associated with glioblastoma.

  6. Detection of aberrant methylation of NPTX2 in pure pancreatic juice samples could be useful as a molecular marker to discriminate between patients with malignant and benign disease of the pancreas

  7. The visual cortex of NARP-deficient transgenic mice is hyperexcitable and unable to express ocular dominance, although many aspects of visual function are unimpaired.

  8. This study showed that the NPTX2 protein is down-regulated in human primary pancreatic cancers and in pancreatic cancer cell lines.

  9. This study demonistrated that childhood-onset mood disorders and suicide attempt association between HOMER1 (show HOMER1 Proteins) rs2290639 and between NPTX2 markers rs705315 and rs1681248.

  10. Demonstrate for the first time that NARP mutation significantly enhances apoptotic death as a result of three distinct lethal mitochondrial apoptotic insults including oxidative, Ca(2 (show CA2 Proteins)+), and lipid stress.

Neuronal Pentraxin II (NPTX2) Protein Profile

Protein Summary

This gene encodes a member of the family of neuronal petraxins, synaptic proteins that are related to C-reactive protein. This protein is involved in excitatory synapse formation. It also plays a role in clustering of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptors at established synapses, resulting in non-apoptotic cell death of dopaminergic nerve cells. Up-regulation of this gene in Parkinson disease (PD) tissues suggests that the protein may be involved in the pathology of PD.

Gene names and symbols associated with Neuronal Pentraxin II Proteins (NPTX2)

  • neuronal pentraxin II (NPTX2)
  • neuronal pentraxin II (LOC100229849)
  • neuronal pentraxin II (LOC100344889)
  • neuro activity regulated petaxin (Narp)
  • neuronal pentraxin 2 (Nptx2)
  • neuronal pentraxin II (Nptx2)
  • NARP protein
  • NP-II protein
  • NP2 protein
  • NPTX2 protein
  • p50 protein

Protein level used designations for Neuronal Pentraxin II Proteins (NPTX2)

neuronal pentraxin II , Neuronal activity regulated pentraxin , NP-II , neuro activity regulated petaxin , neuronal pentraxin-2 , AM50 , NP2 , acrosomal pentaxin-like protein p50 , apexin , neuronal activity-regulated pentaxin , neuronal activity-regulated pentraxin , neuronal pentraxin 2

GENE ID SPECIES
416438 Gallus gallus
463562 Pan troglodytes
718428 Macaca mulatta
100027681 Monodelphis domestica
100081415 Ornithorhynchus anatinus
100229849 Taeniopygia guttata
100344889 Oryctolagus cuniculus
25487 Rattus norvegicus
53324 Mus musculus
100135579 Cavia porcellus
4885 Homo sapiens
288475 Rattus norvegicus
489866 Canis lupus familiaris
100336779 Bos taurus
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