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FMFRamide-related protein precursor plays a role in the regulation of heart rate and blood pressure and the modulation of morphine-induced antinociception. Additionally we are shipping Neuropeptide FF-Amide Peptide Precursor Kits (8) and and many more products for this protein.
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reduction of NPFF release within the dorsal motor nucleus and ambiguus nucleus could serve as a possible cause of the impairment of cardiac vagal control in hypertensive patients
expression of hNPFF2 receptor mRNA was up-regulated by neuropeptide FF
neuropeptide FF and micro-opioid receptor association could be a possible molecular basis for anti-opioid activity
the findings from the early studies on the analgesic and morphine modulating activities suggested a role for NPFF in pain modulation--review
findings suggest that the suppressive signalling of RFRP-3 on Gonadotrophin releasing hormone transcription may dominate over kisspeptin induction in the mHypoA-GnRH/GFP Gonadotrophin releasing hormone neuronal cell model.
Down-regulation of nitric oxide (NO) synthases (NOSs) partially significantly inhibited the viability augmentation of macrophages induced by Npff, implying a nitric oxide synthases- dependent pathway is involved.
RF-amide-related peptide-3 (RFRP (show NPVF Antibodies)-3), the mammalian ortholog of the avian gonadotropin-inhibiting hormone (GnIH), operates via the NPFF1 (show NPFFR1 Antibodies) receptor (NPFF1R) to repress the reproductive axis.
RFRP-3 may exert its effects on reproduction either directly, via Gpr147 in a subset of GnRH neurons, and/or indirectly, via upstream regulators of GnRH.
Interaction between GnRH I (show GNRH1 Antibodies)-RFRP (show NPVF Antibodies)-3 neuropeptides may be involved in the regulation of follicular development and atresia.
It is concluded that aging mice exhibits inverse correlation of RFRP (show NPVF Antibodies)-3 neurons and gonadal activity suggesting that function of RFRP (show NPVF Antibodies)-3 is not initiated until 1-week of age and thereafter it could participate in the regulation of gonadal development.
results demonstrate a small but complex influence of the NPFF system on mouse behavior
RFRP-3 has a likely direct suppressive action on the excitability of GnRH neurons, indicating a role for RFRPs in the regulation of gonadotropin secretion in mammals through modulation of GnRH neuron activity.
We postulate that Oct-1, PDX1, Pit-1, MEIS and DREAM are likely transcriptional regulators of NPFF gene expression.
Npff reduces the expression of cocaine-induced conditioned place preference and cocaine-induce sensitization in mice.
RFamide-related peptide (show NPVF Antibodies)-3 octapeptide suppresses luteinizing hormone (LH) secretion from cultured anterior pituitary cells, as well as LH pulse frequency in cattle.
FMFRamide-related protein precursor plays a role in the regulation of heart rate and blood pressure and the modulation of morphine-induced antinociception. FMRFAL encodes a preproprotein which is cleaved to form two active peptides with similar function.
, RFamide-related peptide
, RFamide related peptide