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Modulates arousal and anxiety. Additionally we are shipping NPS Antibodies (88) and NPS Kits (17) and many more products for this protein.
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Results describe the molecular cloning and tissue distribution of neuropeptide S and neuropeptide S receptors in the pig.
these results indicate that NPS-NPSR system may regulate locomotion together with the CRF1 system in SN.
Study demonstrated that NPS produces anti-aggressive effects in mice through the selective activation of NPSR (show NPSR1 Proteins) and that the endogenous NPS/NPSR (show NPSR1 Proteins) system can exert a role in the control of aggressiveness levels under the present experimental conditions
These data provide evidence for a direct interaction between the corticotropin-releasing factor (show CRH Proteins) and the NPS system and thereby extend previous observations of NPS-modulated stress responsiveness towards a mechanistic level.
Neuropeptide S knock-out mice display deficits in inhibitory avoidance memory indicating involvement in central noradrenergic systems.
Results describe the neuroanatomical, molecular, and functional aspects of neuropeptide S-producing neurons in the mouse brain.
These data demonstrate that the distribution pattern of the central neuropeptide S system is only partially conserved between mice and rats.
results demonstrate that neuropeptide S and NPSR1 (show NPSR1 Proteins) regulate respiratory function through a central nervous system-mediated pathway
Data suggest that lithium evokes antagonistic effects on the mediation of hyperlocomotion and protection against lipid peroxidation induced by neuropeptide S.
analysis of a neuropeptide S responsive circuitry shaping amygdala activity via the endopiriform nucleus
NPS facilitates spatial memory and mitigates MK801-induced spatial memory impairment in mice.
A SNP within the neuropeptide s gene is associated with decreased bioactivity.
NPS is able to stimulate human monocyte chemotaxis and that this effect is entirely due to selective NPSR (show NPSR1 Proteins) activation.
The available information regarding NPS and its receptor and the biological actions modulated by the NPS-NPSR (show NPSR1 Proteins) system, is summarized.
NPS-NPSR1 (show NPSR1 Proteins) signaling is likely involved in anxiety
NPS has a novel role in the stimulation of the hypothalamo-pituitary-adrenal axis
the C-terminal region of neuropeptide S maintains importance for in vivo activity
the key residues of NPS involved in NPSR (show NPSR1 Proteins) activation and suggest a molecular basis for the functional effects of the N107I mutation and for its putative pathophysiological link with asthma
Because remodeling of airway epithelium is a feature of chronic asthma, the up-regulation of MMP10 (show MMP10 Proteins) and TIMP3 (show TIMP3 Proteins) by NPS-NPSR1 (show NPSR1 Proteins) signaling may be of relevance in the pathogenesis of asthma.
NPS acts as a novel modulator of arousal and anxiety-related behaviours by promoting a unique pattern of effects: stimulation associated with anxiolysis.
Modulates arousal and anxiety. May play an important anorexigenic role. Binds to its receptor NPSR1 with nanomolar affinity to increase intracellular calcium concentrations (By similarity).
, prepro-neuropeptide S