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Neutral Cholesterol Ester Hydrolase 1 Proteins (NCEH1)

Hydrolyzes 2-acetyl monoalkylglycerol ether, the penultimate precursor of the pathway for de novo synthesis of platelet-activating factor. Additionally we are shipping NCEH1 Antibodies (28) and NCEH1 Kits (3) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
NCEH1 57552 Q6PIU2
NCEH1 320024 Q8BLF1
NCEH1 294930 B2GV54
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Top NCEH1 Proteins at antibodies-online.com

Showing 10 out of 10 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 7 to 8 Days
$319.00
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
HOST_Wheat germ Human GST tag 2 μg Log in to see 11 to 12 Days
$246.96
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$3,131.33
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$3,131.33
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 3 to 4 Days
$382.86
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

NCEH1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, ,
Mouse (Murine) ,
,
Rat (Rattus)

Top referenced NCEH1 Proteins

  1. Human NCEH1 Protein expressed in Escherichia coli (E. coli) - ABIN1098788 : Okazaki, Igarashi, Nishi, Sekiya, Tajima, Takase, Takanashi, Ohta, Tamura, Okazaki, Yahagi, Ohashi, Amemiya-Kudo, Nakagawa, Nagai, Kadowaki, Osuga, Ishibashi: Identification of neutral cholesterol ester hydrolase, a key enzyme removing cholesterol from macrophages. in The Journal of biological chemistry 2008 (PubMed)
    Show all 2 references for ABIN1098788

More Proteins for Neutral Cholesterol Ester Hydrolase 1 (NCEH1) Interaction Partners

Human Neutral Cholesterol Ester Hydrolase 1 (NCEH1) interaction partners

  1. Psoriasis inflammation induced microRNA targets NCEH1 in underlying subcutaneous adipose tissue.

  2. Pioglitazone increases ABCA1 (show ABCA1 Proteins) expression in an LXR (show NR1H3 Proteins)-dependent manner and NCEH1 expression in an LXRalpha (show NR1H3 Proteins)-independent manner.

  3. Inhibition of AADACL1 activity with a variety of agents blocked platelet aggregation in response to multiple agonists; blocked activation of the small GTPase RAP1 and protein kinase C (PKC).

  4. NCEH1 is expressed in human atheromatous lesions, where it plays a critical role in the hydrolysis of cholesterol ester in human macrophage foam cells, thereby contributing to the initial part of reverse cholesterol transport in human atherosclerosis.

  5. Ritonavir (at 100 mg once daily and 100 mg twice daily significantly down-regulated neutral cholesterol ester hydrolase 1 in 20 healthy individuals.

  6. NCEH is responsible for a major part of nCEH activity in macrophages and may be a potential therapeutic target for the prevention of atherosclerosis.

Mouse (Murine) Neutral Cholesterol Ester Hydrolase 1 (NCEH1) interaction partners

  1. These results suggest that Nceh1 plays a dominant role over Lipe (show LIPE Proteins) in the hydrolysis of CE and subsequent cholesterol efflux in MPMs

  2. reducing the cholesteryl ester content of foam cells, Nceh1 may protect against the pro-apoptotic effect of oxysterols and modulate the development of atherosclerosis.

  3. Gender difference of atherogenesis is partly accounted for activation of neutral cholesterol ester hydrolase (show LIPA Proteins) through estrogen-dependent translocation of A-kinase type II in macrophages.

  4. Nceh1 is involved in the adrenal cholesterol metabolism, and the cholesterol ester hydrolytic activity in adrenal glands is associated with the organ enlargement.

  5. NCEH is targeted to the ER of macrophages, where it hydrolyzes CE to deliver cholesterol for efflux out of the cells.

  6. NCEH is responsible for a major part of nCEH activity in macrophages and may be a potential therapeutic target for the prevention of atherosclerosis.

  7. Genetic ablation of Nceh1 promotes foam cell formation and the development of atherosclerosis in mice.

NCEH1 Protein Profile

Protein Summary

Hydrolyzes 2-acetyl monoalkylglycerol ether, the penultimate precursor of the pathway for de novo synthesis of platelet-activating factor. May be responsible for cholesterol ester hydrolysis in macrophages. Also involved in organ detoxification by hydrolyzing exogenous organophosphorus compounds (By similarity).

Gene names and symbols associated with NCEH1

  • neutral cholesterol ester hydrolase 1 (NCEH1)
  • neutral cholesterol ester hydrolase 1 (nceh1)
  • neutral cholesterol ester hydrolase 1 (Nceh1)
  • Aadacl1 protein
  • B230106I24Rik protein
  • CPO-BP protein
  • MGC79479 protein
  • Nceh protein
  • RGD1311104 protein

Protein level used designations for NCEH1

arylacetamide deacetylase-like 1 , NCEH , neutral cholesterol ester hydrolase 1 , chlorpyrifos oxon-binding protein

GENE ID SPECIES
429158 Gallus gallus
470998 Pan troglodytes
694200 Macaca mulatta
100064432 Equus caballus
100172976 Pongo abelii
493371 Xenopus (Silurana) tropicalis
100010391 Monodelphis domestica
100101305 Xenopus laevis
100395412 Callithrix jacchus
100580453 Nomascus leucogenys
57552 Homo sapiens
488171 Canis lupus familiaris
320024 Mus musculus
294930 Rattus norvegicus
534212 Bos taurus
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