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NSMAF encodes a WD-repeat protein that binds the cytoplasmic sphingomyelinase activation domain of the 55kD tumor necrosis factor receptor. Additionally we are shipping Neutral Sphingomyelinase (N-SMase) Activation Associated Factor Antibodies (46) and Neutral Sphingomyelinase (N-SMase) Activation Associated Factor Kits (3) and many more products for this protein.
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The interaction of FAN with receptor for activated C-kinase 1 (RACK1 (show GNB2L1 Proteins)) appears to be dependent on the folding of the WD repeats into a secondary structure, because no linear binding motifs are identified in the WD-repeat region of FAN.
sphingolipid activator proteins like domain may stabilize the fold of acid sphingomyelinase (show SMPD1 Proteins)
Regulation of NSMAF by TNF-alpha (show TNF Proteins) involves PRKCD (show PKCd Proteins) in lung epithelial cells.
FAN through promoting melanoma cellular motility and tumour invasiveness is critical for the tumour-promoting action of tumor necrosis factor (show TNF Proteins).
FAN is not implicated in the development of methionine and choline deficient diet-induced non-alcoholic steatohepatitis.
the role of FAN and IL-6 (show IL6 Proteins) in the inflammatory response initiated by endotoxin, implicating TNFalpha (show TNF Proteins)
FAN mediates activation of N-SMase as well as regulation of lysosome size by signaling pathways that operate independent from activation/membrane recruitment of PKC.
The results of this study suggest that PH-mediated plasma membrane targeting of FAN is critically involved in tumor necrosis factor (show TNF Proteins)-induced Cdc42 (show CDC42 Proteins) activation and cytoskeleton reorganization.
This is the first report to demonstrate that TNFalpha (show TNF Proteins)-induced sickness behavior is fully mediated by TNF-R1 (show TNFRSF1A Proteins) and that the adaptor protein FAN is a necessary intracellular intermediate for sickness behavior
these results indicate the involvement of FAN in TNF (show TNF Proteins)-induced gene expression and leukocyte recruitment, contributing to the establishment of the specific immune response.
This gene encodes a WD-repeat protein that binds the cytoplasmic sphingomyelinase activation domain of the 55kD tumor necrosis factor receptor. This protein is required for TNF-mediated activation of neutral sphingomyelinase and may play a role in regulating TNF-induced cellular responses such as inflammation. Alternative splicing results in multiple transcript variants.
, factor associated with N-SMase activation
, factor associated with neutral sphingomyelinase activation