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The protein encoded by NCF1 is a 47 kDa cytosolic subunit of neutrophil NADPH oxidase.
The authors demonstrated a significant role of the host NADPH oxidase (show NOX1 Antibodies) in promoting chronic inflammatory pathology in the oviduct following chlamydial infection.
data partly explains the discrepancy of the phenotypes reported earlier utilizing the Ncf1m1J mice or Ncf1 knockout mice.
Data (including data from studies in transgenic mice) suggest that ability to generate Ncf1-derived superoxide, specifically in CD4 (show CD4 Antibodies)-positive T-lymphocytes, is key for development of autoimmune responses in type 1 diabetes.
The Park7 (show PARK7 Antibodies) binds to p47(phox), a subunit of the NADPH oxidase (show NOX1 Antibodies), to promote NADPH oxidase (show NOX1 Antibodies)-dependent production of ROS (show ROS1 Antibodies).
p47(phox)-dependent NADPH oxidases are a major glomerular source of reactive oxygen species, contributing to kidney injury
p47phox mRNA expression was increased in diet-induced obese (DIO) mice. p47phox suppresses collateral vessel growth after femoral artery ligation in DIO mice.
These findings suggest that a p47(phox)-dependent NAD(P)H (show NQO1 Antibodies) oxidase mediates the increase in diaphragm oxidants and contractile dysfunction in chronic heart failure.
The present study provides evidence that augmented EGFRtk impairs vascular function by NADPH oxidase (show NOX1 Antibodies)-dependent mechanism. Therefore, EGFRtk and oxidative stress should be potential targets to treat vascular dysfunction in TD2.
NOX2 (show CYBB Antibodies)/ROS (show ROS1 Antibodies) activity in macrophages signals the development of antigen-specific CD8 (show CD8A Antibodies)(+)T cell response.
p47phox plays a critical role in the regulation of adventitial fibroblast proliferation and migration and may be a new therapeutic target for neointimal hyperplasia
Decreased and increased copy numbers of NCF1 predispose to and protect against SLE.
Lysophosphatidylcholines prime polymorphonuclear neutrophil through Hck (show HCK Antibodies)-dependent activation of PKCdelta (show PKCd Antibodies), which stimulates PKCgamma (show PRKCG Antibodies), resulting in translocation of phosphorylated p47(phox).
There was an increased frequency of the NCF1-339 T allele in patients with systemic lupus erythematosus. The NCF1-339 T allele reduced extracellular ROS (show ROS1 Antibodies) production in neutrophils and led to an increase expression of type 1 interferon (show IFNA Antibodies)-regulated genes.
Skeletal muscle protein expression of the NADPH oxidase (show NOX1 Antibodies) subunits p22(phox (show CYBA Antibodies)), p47(phox), and p67(phox (show NCF2 Antibodies)) was increased in obese relative to lean subjects, where p22(phox (show CYBA Antibodies)) and p67(phox (show NCF2 Antibodies)) expression was attenuated by exercise training in obese subjects.
A novel role for Spns2 (show SPNS2 Antibodies) and S1P1 (show S1PR1 Antibodies)&2 in the activation of p47(phox) and production of reactive oxygen species involved in hyperoxia-mediated lung injury.
Study provides evidence for a novel PKC-zeta (show PRKCZ Antibodies) to p47phox interaction that is required for cell transformation from blebbishields and ROS (show ROS1 Antibodies) production in cancer cells.
Overexpression of p47phox is associated with increased migration/metastasis rate in melanoma.
A rare mutation in NCF1 encoding p47phox of the leukocyte NADPH oxidase (show NOX1 Antibodies) causes lack of superoxide generation, leads to chronic granulomatous disease and was recently (1200-2300 years ago) introduced into the Kavkazi Jewish population
Data show that diphenylene iodonium (DPI (show DSP Antibodies)) and apocynin can reduce hyperoxia-induced reactive oxygen species (ROS (show ROS1 Antibodies)) production by decreasing the translocation and level of NADPH Oxidase (show NOX1 Antibodies) p47phox.
increased levels of gp91phox (show CYBB Antibodies), p47phox and p22phox (show CYBA Antibodies) likely account for the interferon-gamma (show IFNG Antibodies) mediated enhancement of dimethyl sulfoxide-induced Nox2 (show CYBB Antibodies) activity.
Differential Roles of Protein Complexes NOX1 (show NOX1 Antibodies)-NOXO1 (show NOXO1 Antibodies) and NOX2 (show CYBB Antibodies)-p47phox in Mediating Endothelial Redox Responses to Oscillatory and Unidirectional Laminar Shear Stress.
two novel splice variants designed as NCF1-TV1 (retained intron 6) and NCF1-TV2 (retained part of intron 8)encoding two putative truncated proteins (239AA and 283AA). Two splice variants were up-regulated in the mastitis-infected cows' mammary tissues, blood and neutrophils compared with these of healthy cows.
A p47(phox) and Src kinase (show CSK Antibodies) activation of peroxide production by Nox2 (show CYBB Antibodies) appears to be an important contributor to vascular contractile mechanisms mediated through activation of protein kinase C (show PKC Antibodies).
The protein encoded by this gene is a 47 kDa cytosolic subunit of neutrophil NADPH oxidase. This oxidase is a multicomponent enzyme that is activated to produce superoxide anion. Mutations in this gene have been associated with chronic granulomatous disease.
neutrophil cytosolic factor 1
, 47 kDa neutrophil oxidase factor
, NADPH oxidase subunit (47 kD)
, NADPH oxidase subunit (47kDa)
, neutrophil NADPH oxidase factor 1
, neutrophil cytosol factor 1
, 47 kDa autosomal chronic granulomatous disease protein
, NADPH oxidase organizer 2
, SH3 and PX domain-containing protein 1A
, neutrophil cytosolic factor 1, (chronic granulomatous disease, autosomal 1)
, nox organizer 2
, nox-organizing protein 2
, neutrophil cytosolic factor 1 (47kDa, chronic granulomatous disease, autosomal 1)