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Neutrophil Cytosolic Factor 4, 40kDa (NCF4) ELISA Kits

The protein encoded by NCF4 is a cytosolic regulatory component of the superoxide-producing phagocyte NADPH-oxidase, a multicomponent enzyme system important for host defense. Additionally we are shipping Neutrophil Cytosolic Factor 4, 40kDa Antibodies (111) and Neutrophil Cytosolic Factor 4, 40kDa Proteins (9) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
Anti-Mouse NCF4 NCF4 17972 P97369
Anti-Rat NCF4 NCF4 500904  
Anti-Human NCF4 NCF4 4689 Q15080
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More ELISA Kits for Neutrophil Cytosolic Factor 4, 40kDa Interaction Partners

Mouse (Murine) Neutrophil Cytosolic Factor 4, 40kDa (NCF4) interaction partners

  1. p40phox deficiency leads to upregulation of chemokine receptor 1 (show CMKLR1 ELISA Kits) and downregulation of fucosyltransferases and sialyltransferases involved in glycan modifications during experimental intestinal inflammation.

  2. cooperation of p40(phox) with p47(phox) for Nox2 (show CYBB ELISA Kits)-based NADPH oxidase (show NOX1 ELISA Kits) activation during Fcgamma receptor (FcgammaR)-mediated phagocytosis

  3. The defect in Reactive Oxygen Species production and killing of s aureus by p40(phox-/-) neutrophils defines p40(phox) as an essential component in bacterial killing.

  4. p40 (show LANCL1 ELISA Kits)(phoxR58A/R58A) embryos do not develop normally but p40 (show LANCL1 ELISA Kits)(phoxR58A/-) mice are viable and neutrophils from these animals exhibit significantly reduced oxidase responses compared to those from their p40(phox+/-) siblings.

  5. Class III PI3K Vps34 (show PIK3C3 ELISA Kits) is responsible for the synthesis of PtdIns(3)P on phagosomes containing either S aureus or E coli. PtdIns(3)P binding to p40(phox) is important for CD18 (show ITGB2 ELISA Kits)-dependent activation oxidase activation in response to S aureus and E coli

  6. p40(phox) is prephosphorylated in resting endothelial cells and can compensate p47(phox) in keeping basal ROS (show ROS1 ELISA Kits) production.

Human Neutrophil Cytosolic Factor 4, 40kDa (NCF4) interaction partners

  1. NCF4 polymorphism was associated with Crohn's disease, but not ulcerative colitis in Caucasian--{REVIEW}

  2. NCF4 may induce ex- pression of NADPH oxidase (show NOX1 ELISA Kits) enzymes, such as p67phox (show NCF2 ELISA Kits), p47phox (show NCF1 ELISA Kits), p22phox (show CYBA ELISA Kits) and NOX2 (show CYBB ELISA Kits), which lead to increased ROS (show ROS1 ELISA Kits) levels.

  3. Germline variation in NCF4, an innate immunity gene, is associated with an increased risk of colorectal cancer.

  4. The contribution of the functionally relevant NADPH (show NQO1 ELISA Kits) polymorphisms rs1883112 and rs4673 to anthracycline-related heart lesions provides a plausible explanation for their modulation of cardiotoxicity.

  5. Constitutive and inducible intracellular production of reactive oxygen species (ROS (show ROS1 ELISA Kits)) is higher in B cells expressing functional p40phox, supporting a direct role for p40phox in regulating B cell intracellular ROS (show ROS1 ELISA Kits) generation.

  6. Genome-wide association studies-reported associations between the NELL1, NCF4, and FAM92B genes and susceptibility to Crohn's disease could not be replicated in Canadian children and young adults.

  7. Younger age at diagnosis, complicated disease behavior, and ileal disease location are risk factors for perianal CD. First report of an association of the NCF4 gene with perianal disease.

  8. cooperation of p40(phox) with p47(phox) for Nox2 (show CYBB ELISA Kits)-based NADPH oxidase (show NOX1 ELISA Kits) activation during Fcgamma receptor (FcgammaR)-mediated phagocytosis

  9. Results demonstrate that PBEF (show NAMPT ELISA Kits) can prime for PMN (show TBCE ELISA Kits) respiratory burst activity by promoting p40 (show IL9 ELISA Kits) and p47 (show ING1 ELISA Kits) translocation to the membrane.

  10. cytosolic localisation depends on direct interaction with F-actin

Cow (Bovine) Neutrophil Cytosolic Factor 4, 40kDa (NCF4) interaction partners

  1. Study proposes that NCF4 splice variants generated by functional SNP are important risk factors for mastitis susceptibility in dairy cows.

Neutrophil Cytosolic Factor 4, 40kDa (NCF4) Antigen Profile

Antigen Summary

The protein encoded by this gene is a cytosolic regulatory component of the superoxide-producing phagocyte NADPH-oxidase, a multicomponent enzyme system important for host defense. This protein is preferentially expressed in cells of myeloid lineage. It interacts primarily with neutrophil cytosolic factor 2 (NCF2/p67-phox) to form a complex with neutrophil cytosolic factor 1 (NCF1/p47-phox), which further interacts with the small G protein RAC1 and translocates to the membrane upon cell stimulation. This complex then activates flavocytochrome b, the membrane-integrated catalytic core of the enzyme system. The PX domain of this protein can bind phospholipid products of the PI(3) kinase, which suggests its role in PI(3) kinase-mediated signaling events. The phosphorylation of this protein was found to negatively regulate the enzyme activity. Alternatively spliced transcript variants encoding distinct isoforms have been observed.

Gene names and symbols associated with NCF4

  • p40phox protein (p40phox) antibody
  • neutrophil cytosolic factor 4 (LOC100136241) antibody
  • neutrophil cytosolic factor 4 (Ncf4) antibody
  • neutrophil cytosolic factor 4, 40kDa (NCF4) antibody
  • AI451400 antibody
  • NCF antibody
  • P40PHOX antibody
  • SH3PXD4 antibody

Protein level used designations for NCF4

p40phox protein , neutrophil cytosolic factor 4 , NADPH oxidase cytosolic protein p40phox , NCF-4 , neutrophil NADPH oxidase factor 4 , neutrophil cytosol factor 4 , p40-phox , SH3 and PX domain-containing protein 4

GENE ID SPECIES
445891 Takifugu rubripes
100136241 Oncorhynchus mykiss
17972 Mus musculus
500904 Rattus norvegicus
4689 Homo sapiens
481277 Canis lupus familiaris
507859 Bos taurus
100009359 Oryctolagus cuniculus
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