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Nicotinamide Nucleotide Adenylyltransferase 2 Proteins (NMNAT2)

NMNAT2 product belongs to the nicotinamide mononucleotide adenylyltransferase (NMNAT) enzyme family, members of which catalyze an essential step in NAD (NADP) biosynthetic pathway. Additionally we are shipping NMNAT2 Antibodies (36) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
NMNAT2 23057 Q9BZQ4
NMNAT2 226518 Q8BNJ3
NMNAT2 289095 Q0HA29
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Top NMNAT2 Proteins at antibodies-online.com

Showing 10 out of 13 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag 50 μg Log in to see 2 to 3 Days
$441.00
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Baculovirus infected Insect Cells Human His tag 10 μg Log in to see 16 Days
$250.80
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$2,817.83
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$2,817.83
Details
Yeast Xenopus tropicalis His tag   1 mg Log in to see 56 to 66 Days
$2,817.83
Details
Yeast Yeast His tag   1 mg Log in to see 56 to 66 Days
$3,091.00
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   20 μg Log in to see 3 to 4 Days
$388.93
Details

NMNAT2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
,
Mouse (Murine)

Rat (Rattus)

More Proteins for Nicotinamide Nucleotide Adenylyltransferase 2 (NMNAT2) Interaction Partners

Human Nicotinamide Nucleotide Adenylyltransferase 2 (NMNAT2) interaction partners

  1. Knockdown of NMNAT-2 significantly reduces cellular NAD(+) levels and protects cells from p53 (show TP53 Proteins)-dependent cell death upon DNA damage, suggesting an important functional role of NMNAT-2 in p53 (show TP53 Proteins)-mediated signaling.

  2. Nicotinamide mononucleotide adenylyltransferase 2 (NMNAT2) is essential for axon growth and survival.

  3. Overexpression of NMNAT2 in colorectal cancer cells renders them sensitive to Tiazofurin antineoplastic action.

  4. affects tau phosphorylation by regulating PP2A (show PPP2R4 Proteins) activity

  5. Decreased endogenous NMNAT2 function caused by reduced CREB (show CREB1 Proteins) signaling during pathological insults may be one of underlying mechanisms for neuronal death in tauopathies

  6. that overexpression of Nmnat2 in M-cells significantly delayed axon degeneration in vivo

  7. Nmnat2 is a neuronal protein (show LRCH1 Proteins) peripherally attached to membranes via palmitoylation and suggest that Nmnat2 is transported to synaptic terminals via an endosomal pathway.

  8. NMNAT1 (show NMNAT1 Proteins) is a nuclear protein (show RDBP Proteins), whereas NMNAT2 and -3 are localized to the Golgi complex and the mitochondria

  9. ATP binds before NMN (show NTS Proteins) with Golgi apparatus NMNAT2. NMNH conversion to NADH by NMNAT1 (show NMNAT1 Proteins) and NMNAT3 (show NMNAT3 Proteins) occurs at similar rates, conversion by NMNAT2 is much slower.

Mouse (Murine) Nicotinamide Nucleotide Adenylyltransferase 2 (NMNAT2) interaction partners

  1. Active nerve degeneration requires SARM1 (show SARM1 Proteins) and MAP kinases, including DLK (show DAPK3 Proteins), while the NAD+ synthetic enzyme NMNAT2 prevents degeneration.

  2. nicotinamide mononucleotide adenylyltransferase 2-depletion-dependent degeneration of established axons and restricted extension of developing axons are thus both SARM1 (show SARM1 Proteins) dependent

  3. Data indicate that thioesterases APT1 (show FAS Proteins)/APT2 (show TAP2 Proteins) depalmitoylate nicotinamide mononucleotide adenylyltransferase 2 (NMNAT2) and zDHHC17 (show ZDHHC17 Proteins) is the strongest candidate palmitoyltransferase for NMNAT2.

  4. Complete loss of Nmnat2 leads to a mature but distended bladder in utero and is not compatible with survival. Moderate loss of Nmnat2 has no effect on bladder development, survival, and has only modest effects on bladder function later in life.

  5. Together, our results establish Nmnat2 localisation and turnover as a valuable target for modulating axon degeneration in vivo.

  6. results suggest an essential role for NMNAT2 during axon growth

  7. Nmnat2 activity supports axon survival through a site of action distinct from Nmnat2 transport vesicles.

  8. Nmnat2 is involved in axon development or survival in a mammal.

  9. Decreased endogenous NMNAT2 function caused by reduced CREB (show CREB1 Proteins) signaling during pathological insults may be one of underlying mechanisms for neuronal death in tauopathies

  10. Nmnat2 is a neuronal protein (show LRCH1 Proteins) peripherally attached to membranes via palmitoylation and suggest that Nmnat2 is transported to synaptic terminals via an endosomal pathway.

NMNAT2 Protein Profile

Protein Summary

This gene product belongs to the nicotinamide mononucleotide adenylyltransferase (NMNAT) enzyme family, members of which catalyze an essential step in NAD (NADP) biosynthetic pathway. Unlike the other human family member, which is localized to the nucleus, and is ubiquitously expressed\; this enzyme is cytoplasmic, and is predominantly expressed in the brain. Two transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with NMNAT2

  • nicotinamide nucleotide adenylyltransferase 2 (nmnat2)
  • nicotinamide nucleotide adenylyltransferase 2 (NMNAT2)
  • nicotinamide nucleotide adenylyltransferase 2 (Nmnat2)
  • AI843915 protein
  • C1orf15 protein
  • D030041I09Rik protein
  • NMNAT2 protein
  • PNAT1 protein
  • PNAT2 protein
  • wu:fj59g01 protein
  • zgc:73048 protein

Protein level used designations for NMNAT2

NMN adenylyltransferase 2 , naMN adenylyltransferase 1 , nicotinamide mononucleotide adenylyltransferase 2 , nicotinate-nucleotide adenylyltransferase 1 , nicotinamide nucleotide adenylyltransferase 2 , NaMN adenylyltransferase 2 , nicotinate-nucleotide adenylyltransferase 2 , pyridine nucleotide adenylyltransferase 2

GENE ID SPECIES
336257 Danio rerio
610576 Canis lupus familiaris
743583 Pan troglodytes
771393 Gallus gallus
100124800 Xenopus (Silurana) tropicalis
100172391 Pongo abelii
23057 Homo sapiens
226518 Mus musculus
289095 Rattus norvegicus
511042 Bos taurus
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