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NMNAT3 encodes a member of the nicotinamide/nicotinic acid mononucleotide adenylyltransferase family. Additionally we are shipping NMNAT3 Antibodies (68) and many more products for this protein.
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NMNAT3 is absent in mitochondria in human cells, and, akin to plants and yeast, cytosolic NAD maintains the mitochondrial NAD pool.
Red blood cells represent the first human cell type with a remarkable predominance of NMNAT3 over NMNAT1 (show NMNAT1 Proteins); NMNAT2 (show NMNAT2 Proteins) is absent.
NMNAT1 (show NMNAT1 Proteins) is a nuclear protein (show RDBP Proteins), whereas NMNAT2 (show NMNAT2 Proteins) and -3 are localized to the Golgi complex and the mitochondria
NMN (show NTS Proteins) binds before ATP with the mitochondrial isozyme NMNAT3. Only NMNAT3 utilizes ITP (show ITPA Proteins) efficiently in place of ATP, and NMNH conversion to NADH by NMNAT1 (show NMNAT1 Proteins) and NMNAT3 occurs at similar rates.
NMNAT3 regulates the activity of SIRT3 (show SIRT3 Proteins) via synthesis of mitochondria NAD.
Results indicated that Nmnat3 is dispensable in the maintenance of mitochondrial NAD levels, and that other NAD regulatory pathways may exist in mitochondria.
Data indicate that nicotinamide mononucleotide adenylyltransferase 3 (Nmnat3)deficiency causes splenomegaly and hemolytic anemia in mice.
results suggest that axonal protection by NMNAT (show NMNAT1 Proteins) expression in neurons is provided by modifying mitochondrial functionNMNAT activity does lead to axonal protection phenotype in vivo
This gene encodes a member of the nicotinamide/nicotinic acid mononucleotide adenylyltransferase family. These enzymes use ATP to catalyze the synthesis of nicotinamide adenine dinucleotide or nicotinic acid adenine dinucleotide from nicotinamide mononucleotide or nicotinic acid mononucleotide, respectively. The encoded protein is localized to mitochondria and may also play a neuroprotective role as a molecular chaperone. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
nicotinamide mononucleotide adenylyltransferase 3
, nicotinamide nucleotide adenylyltransferase 3
, NMN adenylyltransferase 3
, NaMN adenylyltransferase 3
, nicotinate-nucleotide adenylyltransferase 3
, pyridine nucleotide adenylyltransferase 3
, naMN adenylyltransferase 1
, nicotinate-nucleotide adenylyltransferase 1