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Niemann-Pick Disease, Type C1 (NPC1) ELISA Kits

NPC1 encodes a large protein that resides in the limiting membrane of endosomes and lysosomes and mediates intracellular cholesterol trafficking via binding of cholesterol to its N-terminal domain. Additionally we are shipping NPC1 Antibodies (67) and NPC1 Proteins (10) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
NPC1 18145 O35604
NPC1 4864 O15118
NPC1 266732  
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Top NPC1 ELISA Kits at antibodies-online.com

Showing 6 out of 6 products:

Catalog No. Reactivity Sensitivity Range Quantity Supplier Delivery Price Details
Mouse 7.81pg/ml 31.25-2000 pg/mL 96 Tests Log in to see 11 to 13 Days
$910.56
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Monkey
96 Tests Log in to see 11 to 13 Days
$817.14
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Chicken
96 Tests Log in to see 11 to 13 Days
$817.14
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Sheep
96 Tests Log in to see 11 to 13 Days
$817.14
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Human
96 Tests Log in to see 16 to 21 Days
$999.43
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Rat
96 Tests Log in to see 16 to 21 Days
$999.43
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More ELISA Kits for NPC1 Interaction Partners

Zebrafish Niemann-Pick Disease, Type C1 (NPC1) interaction partners

  1. this is the first report, showing a role of NPC1 in platelet function and formation but further studies are needed to define how cholesterol storage interferes with these processes

  2. npc1 is required early for proper cell movement and cholesterol localization and later for cell survival

Rabbit Niemann-Pick Disease, Type C1 (NPC1) interaction partners

  1. Availability of assays to measure NPC1 binding to membrne proteins may further the understanding of ways in which oxysterols regulate intracellular lipid transport.

Mouse (Murine) Niemann-Pick Disease, Type C1 (NPC1) interaction partners

  1. Our data show that: i) HDAC2 (show HDAC2 ELISA Kits) levels and activity are increased in NPC neuronal models and in Npc1(-/-) mice; ii) inhibition of c-Abl (show ABL1 ELISA Kits) or c-Abl (show ABL1 ELISA Kits) deficiency prevents the increase of HDAC2 (show HDAC2 ELISA Kits) protein levels and activity in NPC neuronal models

  2. This study showed that deleting the Npc1 gene is accompanied by an increase in germ cell apoptosis and compensatory imbalances in the expression of cholesterol enzymatic and transporter factors.

  3. These results show that NPC1 is critical for ebolavirus replication and pathogenesis in animals.

  4. abnormal neuronal expression of matrix metalloproteinase-12 (show MMP12 ELISA Kits) may contribute to axonal degeneration in Niemann-Pick type C disease

  5. There was a transient increase in biliary cholesterol concentration in Npc1(-/-) mice.

  6. data suggest that aberrant expression of Pcdhs is a pathological process accompanied by neurodegeneration in Npc1 mutant mice

  7. This study deministrated that lack of NPC1 in either neurons or glial cells did not affect the excitability of Purkinje cells, the formation of dendrites or their excitatory synaptic activity.

  8. Hearing loss is an early consequence of Npc1 gene deletion in the mouse model of Niemann-Pick disease, type C.

  9. These data show that cholesterol homeostasis through NPC1 plays a crucial role in maintaining insulin (show INS ELISA Kits) action at multiple levels in adipocytes.

  10. Data suggest that axonal pathologies in Npc1 mutant spinal cord are strongly correlated with the increase of activated glial cells, which produce IL-1beta (show IL1B ELISA Kits) and ApoE (show APOE ELISA Kits), resulting in activation of p38-MAPK (show MAPK14 ELISA Kits) signaling pathway and enhanced phosphorylated tau protein

Human Niemann-Pick Disease, Type C1 (NPC1) interaction partners

  1. Fibroblasts from Niemann-Pick type C (NPC) disease patients with low levels of NPC1 protein have high amounts of procathepsin D but reduced quantities of the mature protein, thus showing a diminished cathepsin D (show CTSD ELISA Kits) activity.

  2. Results identified six novel mutations (PKHD1: p.Thr777Met, p.Tyr2260Cys; ABCB11 (show ABCB11 ELISA Kits): p.Val1112Phe, c.611+1G > A, p.Gly628Trpfs*3 and NPC1: p.Glu391Lys) for the diagnostic of inherited infantile cholestatic disorders.

  3. NPC1 mutations are substantially enriched in unexplained early onset ataxia (show USP14 ELISA Kits), making it high risk group for Niemann-Pick disease type C.

  4. these results clearly demonstrated that the over-expression of NPC1 with a defective function in an imatinib-resistant Ph+ acute lymphoblastic leukemia cell line

  5. Structure of glycosylated NPC1 luminal domain C reveals insights into NPC2 (show NPC2 ELISA Kits) and Ebola virus interactions

  6. Study determined the crystal structure of the primed GP (GPcl) of Ebola virus bound to domain C of NPC1 (NPC1-C); NPC1-C utilizes two protruding loops to engage a hydrophobic cavity on head of GPcl. Upon enzymatic cleavage and NPC1-C binding, conformational change in the GPcl further affects the state of the internal fusion loop, triggering membrane fusion.

  7. Here, using live cell imaging, the authors obtained evidence that in contrast to the new model, ebolavirus enters cells through endolysosomes that contain both NPC1 and TPC2 (show TPCN2 ELISA Kits).

  8. These experiments support a model in which NPC1 protein functions to transfer cholesterol past a (show SLC45A1 ELISA Kits) lysosomal glycocalyx.

  9. An isobaric labeling-based quantitative analysis of proteome of NPC1(I1061T) primary fibroblasts when compared with wild-type cells identified 281 differentially expressed proteins based on stringent data analysis criteria, is reported.

  10. NPC1 gene sequencing revealed that he was a compound heterozygote for the p.S954L and p.N1156S mutations.

NPC1 Antigen Profile

Antigen Summary

This gene encodes a large protein that resides in the limiting membrane of endosomes and lysosomes and mediates intracellular cholesterol trafficking via binding of cholesterol to its N-terminal domain. It is predicted to have a cytoplasmic C-terminus, 13 transmembrane domains, and 3 large loops in the lumen of the endosome - the last loop being at the N-terminus. This protein transports low-density lipoproteins to late endosomal/lysosomal compartments where they are hydrolized and released as free cholesterol. Defects in this gene cause Niemann-Pick type C disease, a rare autosomal recessive neurodegenerative disorder characterized by over accumulation of cholesterol and glycosphingolipids in late endosomal/lysosomal compartments.

Gene names and symbols associated with NPC1

  • Niemann-Pick disease, type C1 (NPC1) antibody
  • Niemann-Pick disease, type C1 (npc1) antibody
  • Niemann Pick type C1 (Npc1) antibody
  • Niemann-Pick disease, type C1 (Npc1) antibody
  • A430089E03Rik antibody
  • C85354 antibody
  • Cdig2 antibody
  • D18Ertd139e antibody
  • D18Ertd723e antibody
  • im:7149020 antibody
  • lcsd antibody
  • nmf164 antibody
  • NPC antibody
  • spm antibody
  • wu:fb53a12 antibody
  • wu:fc29a12 antibody

Protein level used designations for NPC1

Niemann-Pick C1 protein , Niemann-Pick type C1 disease protein , Nasopharyngeal carcinoma 1 , Niemann-Pick C1 , Niemann-Pick disease, type C1 , sphingomyelinosis , Niemann-Pick C disease protein

GENE ID SPECIES
403698 Canis lupus familiaris
455338 Pan troglodytes
493693 Felis catus
553330 Danio rerio
579887 Strongylocentrotus purpuratus
100008746 Oryctolagus cuniculus
18145 Mus musculus
4864 Homo sapiens
397591 Sus scrofa
421076 Gallus gallus
266732 Rattus norvegicus
100718604 Cavia porcellus
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