Niemann-Pick Disease, Type C2 (NPC2) ELISA Kits

NPC2 encodes a protein containing a lipid recognition domain. Additionally we are shipping NPC2 Antibodies (86) and NPC2 Proteins (17) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
Anti-Mouse NPC2 NPC2 67963 Q9Z0J0
NPC2 10577 P61916
Anti-Rat NPC2 NPC2 286898  
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Top NPC2 ELISA Kits at

Showing 2 out of 7 products:

Catalog No. Reactivity Sensitivity Range Images Quantity Supplier Delivery Price Details
Human 0.078 ng/mL 0.312-20 ng/mL Typical standard curve 96 Tests Log in to see 15 to 18 Days
Human 0.31 ng/mL 0.781 ng/mL - 50 ng/mL   96 Tests Log in to see 8 to 12 Days

More ELISA Kits for NPC2 Interaction Partners

Mouse (Murine) Niemann-Pick Disease, Type C2 (NPC2) interaction partners

  1. AAV9-mediated NPC1 (show NPC1 ELISA Kits) delivery significantly promoted Purkinje cell survival, restored locomotor activity and coordination, and increased the lifespan of NPC1 (show NPC1 ELISA Kits)(-/-) mice. Our work suggests that AAV-based gene therapy is a promising means to treat NPC (show NPC1 ELISA Kits) disease.

  2. These findings show that NPC2 secreted by premalignant lung tumours suppresses immature macrophage-lineage cell recruitment to the microenvironment in a paracrine manner.

  3. Using the inhibitors of cathepsin enzymatic activity, it was found that cathepsins B and L regulate TNF-alpha (show TNF ELISA Kits) production, the expression and secretion of NPC2 protein, and the mRNA levels of the genes involved in cholesterol trafficking in macrophages.

  4. Npc1 (show NPC1 ELISA Kits) and npc2 deficiencies result in pulmonary abnormalities observed in human Niemann-Pick type C disease.

  5. This is the first report demonstrating that GNMT (show GNMT ELISA Kits) plays an important role in regulating cholesterol homeostasis via interaction with NPC2

  6. NPC1 (show NPC1 ELISA Kits) and NPC2 proteins participate in endosomal/lysosomal processing of both sphingolipids and cholesterol

  7. In liver, absence of either NPC1 (show NPC1 ELISA Kits) or NPC2 resulted in similar alterations in the carbohydrate processing of the lysosomal protease, tripeptidyl peptidase I (show TPP1 ELISA Kits).

  8. The lack of fibronectin (show FN1 ELISA Kits) did not interfere with reconstruction of collagen fibril organization in response to liver injury.

  9. NPC2 is a positive regulator of biliary cholesterol secretion via stimulation of ABCG5 (show ABCG5 ELISA Kits)/G8-mediated cholesterol transport.

  10. Studies showed that processing and export of sterol from the late E/L compartment was quantitatively different in mice lacking LAL (show LIPA ELISA Kits), NPC2, or NPC1 (show NPC1 ELISA Kits) function.

Human Niemann-Pick Disease, Type C2 (NPC2) interaction partners

  1. identification of NPC1 (show NPC1 ELISA Kits) and/or NPC2 mutations combined with descriptions of clinical phenotype, will improve our knowledge of pathogenic mutations and our understanding of genotype-phenotype correlations.

  2. Overall, we provide a mechanism by which npc2-mediated cholesterol transport is controlled by the membrane composition and how npc2-lipid interactions can regulate the transport rate.

  3. Our results suggest that NPC2 is in a mitochondrially associated autophagosome and plays an important role in regulating mitophagy, mitochondrial quality control, and mitochondrial function.

  4. NEGR1 (show NEGR1 ELISA Kits) interacts with NPC2 and increases its protein stability

  5. suggest a general mechanism for NPC2 mediated sterol transfer, in which Phe66, Val96, and Tyr100 act as reversible gate keepers. These residues stabilize the sterol in the binding pose via pi-pi stacking but move transiently apart during sterol release

  6. Study demonstrates that Niemann-Pick type C disease can present in early years of life with pulmonary complications like alveolar proteinosis and hepatosplenomegaly or hepatomegaly due to mutation in NPC2 gene.

  7. Our data suggest an incidence rate for NPC1 (show NPC1 ELISA Kits) and NPC2 of 1/92,104 and 1/2,858,998, respectively. Evaluation of common NPC1 (show NPC1 ELISA Kits) variants, however, suggests that there may be a late-onset NPC1 (show NPC1 ELISA Kits) phenotype with a markedly higher incidence.

  8. Structure of glycosylated NPC1 (show NPC1 ELISA Kits) luminal domain C reveals insights into NPC2 and Ebola virus interactions

  9. hypothesize that, in part, NPC2 rapidly traffics cholesterol between closely appositioned membranes within the multilamellar interior of late endosomal/lysosomal proteins, ultimately effecting cholesterol egress from this compartment

  10. NPC2 may play an important role in negatively regulate cell proliferation.

Cow (Bovine) Niemann-Pick Disease, Type C2 (NPC2) interaction partners

  1. Data suggest ASM (acid sphingomyelinase (show SMPD1 ELISA Kits)) activity is regulated by membrane lipids and facilitates cholesterol transfer by NPC2 (Niemann Pick protein type C2); hydrolysis of sphingomyelin by ASM (show SMPD1 ELISA Kits) may be crucial for endosomal lipid degradation/sorting.

  2. Data show that the effects of the lipids on cholesterol transfer mediated by NPC2 were similar to their effect on membrane fusion induced by NPC2 and saposin-C.

  3. analysis of sterol binding by NPC2, a lysosomal protein deficient in Niemann-Pick type C2 disease

  4. The seminal plasma protein, Niemann-Pick C2 protein, is involved in cholesterol and GM1 depletion within detergent-resistant membrane, then leading to membrane redistribution of P25b that occurs in a very rapid and capacitation-independent manner.

  5. NPC2 plays an important role in endo/lysosomal cholesterol trafficking by markedly accelerating the rates of cholesterol transport. Rates of sterol transfer from and between membranes were increased by as much as 2 orders of magnitude by NPC2.

NPC2 Antigen Profile

Antigen Summary

This gene encodes a protein containing a lipid recognition domain. The encoded protein may function in regulating the transport of cholesterol through the late endosomal/lysosomal system. Mutations in this gene have been associated with Niemann-Pick disease, type C2 and frontal lobe atrophy.

Gene names and symbols associated with NPC2

  • NPC intracellular cholesterol transporter 2 (Npc2) antibody
  • NPC intracellular cholesterol transporter 2 (NPC2) antibody
  • Niemann-Pick disease, type C2 (npc2) antibody
  • 2700012J19Rik antibody
  • AA408070 antibody
  • AU045843 antibody
  • cb292 antibody
  • CE1 antibody
  • EDDM1 antibody
  • EPI-1 antibody
  • HE1 antibody
  • re1 antibody
  • sb:cb292 antibody

Protein level used designations for NPC2

epididymal secretory protein E1 , mE1 , niemann Pick type C2 protein homolog , Niemann-Pick disease type C2 protein , epididymal protein 1 , human epididymis-specific protein 1 , tissue-specific secretory protein , Niemann Pick type C2 , epididymal secretory protein 1 , EPV20 , 16 kDa secretory protein , 16kDa secretory protein , 16.5 kDa secretory protein

67963 Mus musculus
10577 Homo sapiens
286898 Rattus norvegicus
280815 Bos taurus
403920 Canis lupus familiaris
397410 Sus scrofa
450192 Pan troglodytes
282673 Danio rerio
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