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Nipped-B Homolog (Drosophila) (NIPBL) ELISA Kits

NIPBL encodes the homolog of the Drosophila melanogaster Nipped-B gene product and fungal Scc2-type sister chromatid cohesion proteins. Additionally we are shipping NIPBL Antibodies (49) and NIPBL Proteins (2) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
Anti-Human NIPBL NIPBL 25836 Q6KC79
Anti-Mouse NIPBL NIPBL 71175 Q6KCD5
Anti-Rat NIPBL NIPBL 294787  
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More ELISA Kits for NIPBL Interaction Partners

Zebrafish Nipped-B Homolog (Drosophila) (NIPBL) interaction partners

  1. Nipbl and mediator cooperatively regulate gene expression to control limb development.

  2. The present s (show WNT2 ELISA Kits)tudy focuses on th (show CCND1 ELISA Kits)e role of the zebrafish nipblb paralog during neural development.

  3. Nipbl-deficient embryos showed changes in the expression of genes involved in the specification of endoderm, which gives rise to gut (show GUSB ELISA Kits) and provides a substrate for cardiac precursor migration, as well as genes that regulate left-right asymmetry

Human Nipped-B Homolog (Drosophila) (NIPBL) interaction partners

  1. NIPBL expression conferred poor prognosis and resistance to chemotherapy in non-small cell lung cancer

  2. Scc2 normally promotes a gene expression program that supports translational fidelity. . translational dysfunction may contribute to the human disorder Cornelia de Lange syndrome, which is caused by mutations in NIPBL, the human ortholog of SCC2.

  3. There was an increased frequncy of NIPBL mutations in a cohort of prenatal ultrasound detected phenotypes of Cornelia de Lange syndrome.

  4. A new Sanger sequencing reveals new hidden mutations in NIPBL gene not detected with conventional approach.

  5. analysis of the mutation spectrum of NIPBL in in Chinese patients with Cornelia de Lange syndrome

  6. Nine mutations affecting splice-sites in the NIPBL gene and four new splicing isoforms DeltaE10, DeltaE12, DeltaE33,34, and B' was identified in twelve CdLS patients.

  7. defects of NIPBL might lead to cohesin-loading defects and thereby alter gene expression and second, NIPBL deficiency might affect genes directly via its role at the respective promoters.

  8. Results show that NIPBL has a function in modulating chromatin architecture that is not dependent on SMC3 (show SMC3 ELISA Kits)/cohesin or CTCF (show CTCF ELISA Kits) in classical Cornelia de Lange syndrome.

  9. Letter/Case Report: novel NIPBL mutation giving rise to Cornelia de Lange syndrome and intrauterine fetal death.

  10. Canonical WNT (show WNT2 ELISA Kits) pathway and CCND1 (show CCND1 ELISA Kits) downregulation was observed in NIPBL-mutated patient-specific fibroblasts.

Mouse (Murine) Nipped-B Homolog (Drosophila) (NIPBL) interaction partners

  1. expression analysis of Smc1a (show SMC1A ELISA Kits) and Nipbl in developing mouse embryos reveals a specific pattern in the hindbrain

  2. Nipbl and mediator cooperatively regulate gene expression to control limb development.

  3. Nipbl+/- mutants are growth-retarded and exhibit various skeletal and craniofacial malformations.

  4. In spermatocytes, Nipbl/Mau2 then relocalises to chromocenters, whereas in oocytes it remains bound to chromosomal axes throughout prophase to dictyate arrest.

  5. Reduction of Nipbl is associated with Cornelia de Lange Syndrome.

  6. Mice heterozygous for a gene-trap mutation in Nipbl were produced and exhibited defects characteristic of Cornelia de Lange Syndrome.

NIPBL Antigen Profile

Antigen Summary

This gene encodes the homolog of the Drosophila melanogaster Nipped-B gene product and fungal Scc2-type sister chromatid cohesion proteins. The Drosophila protein facilitates enhancer-promoter communication of remote enhancers and plays a role in developmental regulation. It is also homologous to a family of chromosomal adherins with broad roles in sister chromatid cohesion, chromosome condensation, and DNA repair. The human protein has a bipartite nuclear targeting sequence and a putative HEAT repeat. Condensins, cohesins and other complexes with chromosome-related functions also contain HEAT repeats. Mutations in this gene result in Cornelia de Lange syndrome, a disorder characterized by dysmorphic facial features, growth delay, limb reduction defects, and mental retardation. Two transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with NIPBL

  • Nipped-B homolog (NIPBL) antibody
  • Nipped-B homolog (nipbl-b) antibody
  • nipped-B homolog (NIPBL) antibody
  • Nipped-B homolog (Drosophila) (NIPBL) antibody
  • nipped-b homolog b (Drosophila) (nipblb) antibody
  • Nipped-B homolog (Drosophila) (nipbl) antibody
  • Nipped-B homolog (Drosophila) (Nipbl) antibody
  • 4921518A06Rik antibody
  • 4933421G18Rik antibody
  • C79399 antibody
  • CDLS antibody
  • CDLS1 antibody
  • Idn3 antibody
  • IDN3-B antibody
  • NIPBL antibody
  • nipbla antibody
  • Scc2 antibody
  • scc2-2 antibody
  • SCC2W antibody
  • wu:fi33d08 antibody

Protein level used designations for NIPBL

Nipped-B homolog , Scc2-2A , Scc2-2B , delangin , sister chromatid cohesion establishment factor 2 , nipped-B homolog , Nipped-B homolog (Drosophila) , nipped-B like a , nipped-B-like protein B , nipped-B-like protein-like , SCC2 homolog , nipped-B-like protein , sister chromatid cohesion 2 homolog , delangin homolog

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701209 Macaca mulatta
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100014459 Monodelphis domestica
100053547 Equus caballus
100077677 Ornithorhynchus anatinus
100164947 Acyrthosiphon pisum
100403994 Callithrix jacchus
100479499 Ailuropoda melanoleuca
100561843 Anolis carolinensis
100603589 Nomascus leucogenys
100624231 Sus scrofa
25836 Homo sapiens
100172233 Pongo abelii
489226 Canis lupus familiaris
539566 Bos taurus
71175 Mus musculus
294787 Rattus norvegicus
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