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Has a omega-amidase activity. Additionally we are shipping NIT2 Antibodies (33) and NIT2 Proteins (16) and many more products for this protein.
Downregulation of NIT2 inhibits colon cancer cell proliferation and induces cell cycle arrest through the caspase-3 (show CASP3 ELISA Kits) and PARP (show COL11A2 ELISA Kits) pathways
Human NIT1/2 (show NIT1 ELISA Kits) are not involved in the metabolism of vildagliptin.
The activity and substrate specificity of human Nit2 was determined with alpha-ketoglutaramate and succinamate as substrates.
Genotype analysis in 4 types of tumor tissue showed allelic imbalance surrounding NIT2 locus; results show that NIT2 plays an important role in cell growth inhibition & links to malignancies, suggesting Nit2 may be a potential tumor suppressor candidate
Data conclude that mammalian nitrilase 2 is omega-amidase (show GATA1 ELISA Kits).
Has a omega-amidase activity. The role of omega-amidase is to remove potentially toxic intermediates by converting alpha- ketoglutaramate and alpha-ketosuccinamate to biologically useful alpha-ketoglutarate and oxaloacetate, respectively (By similarity).
Nit protein 2
, Nitrilase homolog 2-A
, nitrilase homolog 2
, omega-amidase NIT2-A
, nitrilase family, member 2
, omega-amidase NIT2
, Nitrilase homolog 2