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Has a omega-amidase activity. Additionally we are shipping NIT2 Antibodies (33) and many more products for this protein.
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Human NIT2 Protein expressed in Escherichia coli (E. coli) - ABIN667846
Barglow, Saikatendu, Bracey, Huey, Morris, Olson, Stevens, Cravatt: Functional proteomic and structural insights into molecular recognition in the nitrilase family enzymes. in Biochemistry 2008
Show all 2 references for 667846
Downregulation of NIT2 inhibits colon cancer cell proliferation and induces cell cycle arrest through the caspase-3 (show CASP3 Proteins) and PARP pathways
Human NIT1/2 (show NIT1 Proteins) are not involved in the metabolism of vildagliptin.
The activity and substrate specificity of human Nit2 was determined with alpha-ketoglutaramate and succinamate as substrates.
Genotype analysis in 4 types of tumor tissue showed allelic imbalance surrounding NIT2 locus; results show that NIT2 plays an important role in cell growth inhibition & links to malignancies, suggesting Nit2 may be a potential tumor suppressor candidate
Data conclude that mammalian nitrilase 2 is omega-amidase (show GATA1 Proteins).
Has a omega-amidase activity. The role of omega-amidase is to remove potentially toxic intermediates by converting alpha- ketoglutaramate and alpha-ketosuccinamate to biologically useful alpha-ketoglutarate and oxaloacetate, respectively (By similarity).
Nit protein 2
, Nitrilase homolog 2-A
, nitrilase homolog 2
, omega-amidase NIT2-A
, nitrilase family, member 2
, omega-amidase NIT2
, Nitrilase homolog 2