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Noggin Proteins (NOG)

The secreted polypeptide, encoded by NOG, binds and inactivates members of the transforming growth factor-beta (TGF-beta) superfamily signaling proteins, such as bone morphogenetic protein-4 (BMP4). Additionally we are shipping Noggin Antibodies (146) and Noggin Kits (14) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
NOG 9241 Q13253
NOG 18121 P97466
NOG 25495  
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Top Noggin Proteins at antibodies-online.com

Showing 10 out of 69 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human Un-conjugated 100 μg Log in to see 2 to 3 Days
$651.00
Details
HOST_Human Cells Human Fc Tag 100 μg Log in to see 16 Days
$382.80
Details
HOST_Human Cells Mouse Fc Tag 100 μg Log in to see 16 Days
$657.80
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_HEK-293 Human Un-conjugated   5 μg Log in to see 10 to 12 Days
$86.96
Details
HOST_Escherichia coli (E. coli) Mouse Un-conjugated   5 μg Log in to see 10 to 12 Days
$86.96
Details
HOST_HEK-293 Human Un-conjugated 50 μg Log in to see 2 to 3 Days
$1,013.25
Details
HOST_HEK-293 Cells Human Fc Tag 100 μg Log in to see 2 to 3 Days
$374.00
Details
HOST_Escherichia coli (E. coli) Mouse Un-conjugated   20 μg Log in to see 10 to 12 Days
$233.72
Details

NOG Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , , , , ,
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Mouse (Murine) , ,
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Rat (Rattus) ,
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Top referenced Noggin Proteins

  1. Mouse (Murine) NOG Protein expressed in Escherichia coli (E. coli) - ABIN2666487 : Bonaguidi, Peng, McGuire, Falciglia, Gobeske, Czeisler, Kessler: Noggin expands neural stem cells in the adult hippocampus. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2008 (PubMed)
    Show all 6 references for ABIN2666487

  2. Human NOG Protein expressed in HEK-293 - ABIN2666472 : Chiba, Lee, Zhou, Freed: Noggin enhances dopamine neuron production from human embryonic stem cells and improves behavioral outcome after transplantation into Parkinsonian rats. in Stem cells (Dayton, Ohio) 2008 (PubMed)
    Show all 6 references for ABIN2666472

  3. Mouse (Murine) NOG Protein expressed in Escherichia coli (E. coli) - ABIN2667559 : Gong, Krakow, Marcelino, Wilkin, Chitayat, Babul-Hirji, Hudgins, Cremers, Cremers, Brunner, Reinker, Rimoin, Cohn, Goodman, Reardon, Patton, Francomano, Warman: Heterozygous mutations in the gene encoding noggin affect human joint morphogenesis. in Nature genetics 1999 (PubMed)
    Show all 6 references for ABIN2667559

  4. Mouse (Murine) NOG Protein expressed in Human Cells - ABIN2008158 : Brunet, McMahon, McMahon, Harland: Noggin, cartilage morphogenesis, and joint formation in the mammalian skeleton. in Science (New York, N.Y.) 1998 (PubMed)
    Show all 6 references for ABIN2008158

  5. Human NOG Protein expressed in Human Cells - ABIN2002466 : Groppe, Greenwald, Wiater, Rodriguez-Leon, Economides, Kwiatkowski, Affolter, Vale, Izpisua Belmonte, Choe: Structural basis of BMP signalling inhibition by the cystine knot protein Noggin. in Nature 2002 (PubMed)
    Show all 5 references for ABIN2002466

  6. Human NOG Protein expressed in Escherichia coli (E. coli) - ABIN413676 : Umezu, Yamanouchi, Iida, Miura, Tomooka: Follistatin-like-1, a diffusible mesenchymal factor determines the fate of epithelium. in Proceedings of the National Academy of Sciences of the United States of America 2010 (PubMed)

More Proteins for Noggin (NOG) Interaction Partners

Human Noggin (NOG) interaction partners

  1. An imbalance between BMP-2 (show BMP2 Proteins) and Noggin secretion induces abnormal osteogenic differentiation of ankylosing spondylitis-mesenchymal stem cells.

  2. early noggin exposure may play a specific role in the directed differentiation of DA cells from human embryonic stem cells.

  3. Novel p.W150C NOG mutation associated with proximal symphalangism and conductive hearing impairment was identified in a Chinese family.Impaired dimerization of mutant NOG is an important pathogenic mechanism for the NOG-related disorder.

  4. No association between SPRY2 (show SPRY2 Proteins), single-nucleotide polymorphisms, and nonsyndromic cleft lip with or without cleft palate risk were observed in this cohort of patients.

  5. The study did not provide support for NOG being the causal gene at 17q22 in nonsyndromic cleft lip with or without cleft palate.

  6. a novel NOG mutation in a Chinese family with proximal symphalangism

  7. this study proposes that the decreased binding affinity of NOG with the p.R136C mutation to HSPG leads to an excess of bone morphogenetic protein signaling and underlies the proximal symphalangism and conductive hearing loss phenotype of carriers.

  8. High-quality studies show that otosclerosis in Japanese patients is not linked to the NOG gene. [Review]

  9. Even though gremlin 1 (show GREM1 Proteins) and noggin were not widely expressed in adult tissues, in a subset of organs their expression pattern indicated a potential role in normal tissue homeostasis as well as in malignancies.

  10. A novel heterozygous change of p. R42T [c.C124A (CCC > ACC)] leading to a proline was identified in a family with multiple synostoses syndrome.

Mouse (Murine) Noggin (NOG) interaction partners

  1. we observed a glial reaction and an activity-dependent modification of Shh (show SHH Proteins), Noggin, and Numb (show NUMB Proteins) proteins. we found that Shh (show SHH Proteins) and Noggin could affect motor performance and that these proteins could be associated with both TDP-43 (show TARDBP Proteins) and Numb (show NUMB Proteins)

  2. Molecular analysis demonstrated that ectopic Noggin-expressing regions in the early heart's pacemaker region, failed to express the potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 (show HCN4 Proteins)

  3. endogenous Bmp2 (show BMP2 Proteins), Bmp4 (show BMP4 Proteins), and Noggin transcript levels in postnatal bone and cartilage mirrored the activity of their respective reporters in these tissues

  4. A band of noggin-expressing cells insulates a region of proliferative chondrocytes from the influence of BMP signaling, allowing them to differentiate as articular cartilage upon exposure to Wnt (show WNT2 Proteins) signaling emanating from the interzone.

  5. Taken together, these results show that hair follicle development in Trps1 KO embryos is impaired directly or indirectly by decreased Noggin expression.

  6. BMP signaling was stimulated in adipose derived stem cells (ASCs) by downregulating noggin.

  7. The axial midline domain of Nog expression is critical to promote pharyngeal arch 1 development in early stages, necessary for adequate outgrowth of the mandibular bud.

  8. Follistatin (show FST Proteins) aids in maintaining proper somite size, and consequently sclerotome progenitor numbers, by preventing paraxial mesoderm from adopting an intermediate/lateral plate mesodermal fate in the Noggin-deficient state.

  9. Noggin antagonizes BMP, which is required in presumptive notochord cells for mammalian foregut morphogenesis

  10. Noggin is expressed constantly in Meckel's cartilage (MC) and in the absence of Noggin, MC is significantly thickened attributing to dramatically elevated cell proliferation rate associated with enhanced phosphorylation of Smad1 (show SMAD1 Proteins)/5/8.

Cow (Bovine) Noggin (NOG) interaction partners

  1. Noggin did not affect oocyte nuclear maturation. Noggin supplementation up-regulated the expression of HSP70 and MATER genes in matured oocytes.

  2. Noggin, a cytokine inhibiting the BMP4 pathway, successfully upregulated the relative expression of NANOG mRNA in the ICM explants with respect to controls.

Xenopus laevis Noggin (NOG) interaction partners

  1. a new role for Noggin1 in determining specific anterior neural structures by the modulation of TGFbeta (show TGFB1 Proteins) and SHH (show SHH Proteins) signaling.

  2. This allow one to compare the expression levels of Noggin1 and Noggin 2 constructs, to purify them on the affine immunosorbent and to show the activity of Noggin proteins by analyzing their ability to bind BMP4 (show BMP4 Proteins) factor

  3. Both Noggin proteins could induce a secondary head, including the forebrain. During normal development, Noggin1 mRNA was translated with low efficiency, providing sufficient Noggin1 only for antagonizing Bone morphogenetic protein.

  4. A 2066 bp noggin 5' flanking sequence which recapitulates the roof-plate expression of endogenous gene in transgenic frog tadpoles has been identified; this roof-plate enhancer has been mapped to a sequence as short as 79 bp.

  5. Noggin specifically blocks chondrogenic differentiation, rather than osteogenic differentiation, in mesodermal stem cell line C1 and skeletal cells.

  6. Chordin (show CHRD Proteins), Noggin, beta-Catenin (show CTNNB1 Proteins), and Cerberus (show CER1 Proteins) have roles in neural induction in Xenopus

  7. X-epilectin expression is down-regulated by Noggin and tBR and that this effect is inhibited by BMP4 over-expression, suggesting X-epilectin expression is mediated by the BMP signalling pathway

  8. maternal mRNA encoding noggin is enriched in animal tiers and at low concentrations in the C-tier, suggesting that the neural fates of C-tier blastomeres may be responsive to early signaling from their neighboring cells

Noggin (NOG) Protein Profile

Protein Summary

The secreted polypeptide, encoded by this gene, binds and inactivates members of the transforming growth factor-beta (TGF-beta) superfamily signaling proteins, such as bone morphogenetic protein-4 (BMP4). By diffusing through extracellular matrices more efficiently than members of the TGF-beta superfamily, this protein may have a principal role in creating morphogenic gradients. The protein appears to have pleiotropic effect, both early in development as well as in later stages. It was originally isolated from Xenopus based on its ability to restore normal dorsal-ventral body axis in embryos that had been artificially ventralized by UV treatment. The results of the mouse knockout of the ortholog suggest that it is involved in numerous developmental processes, such as neural tube fusion and joint formation. Recently, several dominant human NOG mutations in unrelated families with proximal symphalangism (SYM1) and multiple synostoses syndrome (SYNS1) were identified\; both SYM1 and SYNS1 have multiple joint fusion as their principal feature, and map to the same region (17q22) as this gene. All of these mutations altered evolutionarily conserved amino acid residues. The amino acid sequence of this human gene is highly homologous to that of Xenopus, rat and mouse.

Gene names and symbols associated with Noggin Proteins (NOG)

  • noggin (NOG)
  • noggin protein (noggin)
  • noggin (LOC100033935)
  • noggin (Nog)
  • noggin (nog)
  • nog-A protein
  • nog1 protein
  • noggin protein
  • noggin-1 protein
  • SYM1 protein
  • SYNS1 protein

Protein level used designations for Noggin Proteins (NOG)

noggin , noggin protein , symphalangism 1 (proximal) , cNoggin , noggin 1

GENE ID SPECIES
780490 Ovis aries
468413 Pan troglodytes
707338 Macaca mulatta
778701 Ciona intestinalis
100033935 Equus caballus
100526667 Canis lupus familiaris
9241 Homo sapiens
18121 Mus musculus
25495 Rattus norvegicus
373912 Gallus gallus
100683515 Canis lupus familiaris
574073 Sus scrofa
538769 Bos taurus
373646 Xenopus laevis
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