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Non-SMC Element 2, MMS21 Homolog (S. Cerevisiae) Proteins (NSMCE2)

E3 SUMO-protein ligase component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. Additionally we are shipping NSMCE2 Antibodies (67) and NSMCE2 Kits (1) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
NSMCE2 111648  
NSMCE2 286053 Q96MF7
NSMCE2 299957 Q4V8A0
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Top NSMCE2 Proteins at antibodies-online.com

Showing 8 out of 8 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Xenopus laevis His tag   1 mg Log in to see 56 to 66 Days
$2,603.33
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$2,632.67
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$2,634.50
Details
Yeast Schizosaccharomyces pombe His tag   1 mg Log in to see 56 to 66 Days
$2,641.83
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   50 μg Log in to see 9 to 11 Days
$229.85
Details

NSMCE2 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human ,
,
Rat (Rattus)

More Proteins for Non-SMC Element 2, MMS21 Homolog (S. Cerevisiae) (NSMCE2) Interaction Partners

Mouse (Murine) Non-SMC Element 2, MMS21 Homolog (S. Cerevisiae) (NSMCE2) interaction partners

  1. SUMO- and BLM-independent activities of NSMCE2 limit recombination and facilitate chromosome segregation.

Human Non-SMC Element 2, MMS21 Homolog (S. Cerevisiae) (NSMCE2) interaction partners

  1. our study identified novel PVT1-NSMCE2 and CCDC26-NSMCE2 fusion genes that may play functional roles in leukemia.

  2. support a role for NSMCE2 in recovery from DNA damage and raise the possibility that loss of its function produces dwarfism through reduced tolerance of replicative stress

  3. show that the Smc5 (show SMC5 Proteins)/6 subunit Mms21 sumoylates multiple lysines of the cohesin subunit Scc1 (show PTPRJ Proteins)

  4. Studies indicate that Nse1 (show FAM84A Proteins) may function as a ubiquitin ligase, and is targeted to chromatin through its interaction with the Smc5 (show SMC5 Proteins)/6 complex.

  5. the human SMC5 (show SMC5 Proteins)/6 complex and the SUMO ligase activity of hMMS21 are required for the prevention of DNA damage-induced apoptosis by facilitating DNA repair in human cells

  6. MMS21 dependent sumoylation is integral and important to the cohesion mechanism and mitotic progression and that this function appears to be independent of SMC6 (show SMC6 Proteins).

NSMCE2 Protein Profile

Protein Summary

E3 SUMO-protein ligase component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. Is not be required for the stability of the complex.The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination and mediates sumoylation of shelterin complex (telosome) components. Acts as a E3 ligase mediating SUMO attachment to various proteins such as SMC6L1 and TRAX, the shelterin complex subunits TERF1, TERF2, TINF2 and TERF2IP, and maybe the cohesin components RAD21 and STAG2. Required for recruitment of telomeres to PML nuclear bodies. SUMO protein-ligase activity is required for the prevention of DNA damage-induced apoptosis by facilitating DNA repair. Required for sister chromatid cohesion during prometaphase and mitotic progression (By similarity).

Gene names and symbols associated with NSMCE2

  • E3 SUMO-protein ligase NSE2 (nsmce2)
  • minisatellites detected by probe MMS21 (Ms21)
  • non-SMC element 2 homolog (MMS21, S. cerevisiae) (Nsmce2)
  • non-SMC element 2, MMS21 homolog (S. cerevisiae) (NSMCE2)
  • non-SMC element 2, MMS21 homolog (S. cerevisiae) (Nsmce2)
  • 1110014D18Rik protein
  • AI661537 protein
  • C8orf36 protein
  • MMS21 protein
  • NSE2 protein
  • RGD1305156 protein
  • ZMIZ7 protein

Protein level used designations for NSMCE2

MMS21 homolog , non-SMC element 2 homolog , non-structural maintenance of chromosomes element 2 homolog , E3 SUMO-protein ligase NSE2 , hMMS21 , methyl methanesulfonate sensitivity gene 21 , zinc finger, MIZ-type containing 7 , non-SMC element 2 homolog (MMS21, S. cerevisiae)

GENE ID SPECIES
379272 Xenopus laevis
111648 Mus musculus
68501 Mus musculus
286053 Homo sapiens
519974 Bos taurus
299957 Rattus norvegicus
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