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Component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. Additionally we are shipping NSMCE1 Proteins (9) and many more products for this protein.
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Chicken Polyclonal NSMCE1 Primary Antibody for WB - ABIN2781253
Fujioka, Kimata, Nomaguchi, Watanabe, Kohno: Identification of a novel non-structural maintenance of chromosomes (SMC) component of the SMC5-SMC6 complex involved in DNA repair. in The Journal of biological chemistry 2002
Component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT- associated PML bodies (APBs). Has in vitro ubiquitin ligase activity in presence of NDNL2. Is involved in positive regulation of response to DNA damage stimulus.
non-structural maintenance of chromosomes element 1 homolog
, non-SMC element 1 homolog (S. cerevisiae)