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anti-Norrie Disease (Pseudoglioma) (NDP) Antibodies

NDP encodes a secreted protein with a cystein-knot motif that activates the Wnt/beta-catenin pathway. Additionally we are shipping Norrie Disease (Pseudoglioma) Proteins (7) and Norrie Disease (Pseudoglioma) Kits (5) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
NDP 4693 Q00604
NDP 363443  
NDP 17986 P48744
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Top anti-Norrie Disease (Pseudoglioma) Antibodies at antibodies-online.com

Showing 10 out of 25 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Chicken Rabbit Un-conjugated IHC, WB WB Suggested Anti-NDP Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:312500Positive Control: Human Liver Immunohistochemistry with Brain, cortex tissue at an antibody concentration of 5µg/ml using anti-NDP antibody (ARP56082_P050) 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated EIA, IF, WB Immunocytochemistry of Norrin in Jurkat cells with this product at 5 μg/ml. Western blot analysis of Norrin in Jurkat cell lysate with this product at (A) 1 and (B) 2 μg/ml. 0.1 mg Log in to see 6 to 8 Days
$401.50
Details
Human Rabbit Un-conjugated IHC, WB 100 μL Log in to see 14 Days
$369.79
Details
Human Rabbit Un-conjugated ICC, ELISA, WB 100 μg Log in to see 8 to 10 Days
$522.50
Details
Human Rabbit Un-conjugated WB   50 μL Log in to see 8 to 10 Days
$390.50
Details
Human Rabbit Un-conjugated WB NDP antibody used at 1 ug/ml to detect target protein. 50 μg Log in to see 3 to 4 Days
$473.93
Details
Human Rabbit Un-conjugated WB   200 μL Log in to see 9 Days
$487.50
Details
Human Mouse Un-conjugated ELISA, WB   100 μg Log in to see 8 to 10 Days
$793.83
Details
Human Mouse Un-conjugated WB Western Blot analysis of NDP expression in transfected 293T cell line by NDP MaxPab polyclonal antibody.Lane 1: NDP transfected lysate(14.63 KDa).Lane 2: Non-transfected lysate. 50 μg Log in to see 9 Days
$430.00
Details
Human Rabbit Un-conjugated IHC   100 μL Log in to see 8 to 10 Days
$581.17
Details

NDP Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality
Human , ,
,
,
Rat (Rattus)


Mouse (Murine)


Top referenced anti-Norrie Disease (Pseudoglioma) Antibodies

  1. Human Polyclonal NDP Primary Antibody for EIA, IF - ABIN500373 : Ohlmann, Scholz, Goldwich, Chauhan, Hudl, Ohlmann, Zrenner, Berger, Cvekl, Seeliger, Tamm: Ectopic norrin induces growth of ocular capillaries and restores normal retinal angiogenesis in Norrie disease mutant mice. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2005 (PubMed)
    Show all 4 references for ABIN500373

  2. Chicken Polyclonal NDP Primary Antibody for IHC, WB - ABIN2786504 : Khan, Aldahmesh, Meyer: Correlation of ophthalmic examination with carrier status in females potentially harboring a severe Norrie disease gene mutation. in Ophthalmology 2008 (PubMed)

More Antibodies against Norrie Disease (Pseudoglioma) Interaction Partners

Human Norrie Disease (Pseudoglioma) (NDP) interaction partners

  1. These structural, biophysical and cellular data, map Fz4 (show FZD4 Antibodies) and putative Lrp5 (show LRP5 Antibodies)/6 binding sites to distinct patches on Norrin, and reveal a GAG binding site spanning Norrin and Fz4 (show FZD4 Antibodies) cysteine-rich domain.

  2. Genetic evaluation of a case of bilateral leukocoria and asymmetric microphthalmia revealed a previously undescribed mutation in the Norrie disease protein gene.

  3. Norrin may play a role in the regulation of angiogenesis.

  4. Norrin induces the formation of a ternary complex with Fz4 (show FZD4 Antibodies) and Lrp5 (show LRP5 Antibodies)/6 by binding to their respective extracellular domains

  5. Report of a missense mutation, p.Arg41Ser, in NDP causing Norrie disease in an Indian family.

  6. Multi-functional norrin is a ligand for the LGR4 (show LGR4 Antibodies) receptor.

  7. NDP mutations are common cause of Norrie disease but might be rare cause for familial exudative vitreoretinopathy (FEVR) in Chinese.

  8. Norrin has a neuroprotective role for retinal neurons independent from its role on the growth of retinal capillaries.

  9. Mutation screening of the NDP gene identified a novel nonsense mutation, c.343C>T.

  10. A novel Norrin missense mutation, p.Arg41Thr, was identified in two apparently unrelated families with Norrie disease

Xenopus laevis Norrie Disease (Pseudoglioma) (NDP) interaction partners

  1. xNorrin promotes dorsal and anterior neural formation by acting on two major signaling pathways, Wnt (show WNT2 Antibodies) and TGF-beta (show TGFB1 Antibodies), in opposite ways and is essential for early neuroectoderm specification.

Mouse (Murine) Norrie Disease (Pseudoglioma) (NDP) interaction partners

  1. The endogenously expressed Lgr4 (show LGR4 Antibodies) may act as an antagonist molecule that helps to fine-tune the R-spondin/norrin-mediated Lgr4 (show LGR4 Antibodies)-Wnt (show WNT2 Antibodies) signaling during gonadal development.

  2. Multi-functional norrin is a ligand for the LGR4 (show LGR4 Antibodies) receptor.

  3. In this study we demonstrate, for the first time, that Norrin protein is expressed along the retinal blood vessels.

  4. Taken together, we have uncovered a cell autonomous function for Ndp in retinal progenitor proliferation that is independent of its function in the retinal vasculature, which could explain the neural defects associated with Norrie disease

  5. We conclude that constitutive overexpression of Norrin protects photoreceptors from light damage, an effect that is mediated by Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) and EDN2 (show EDN2 Antibodies) signaling and involves neurotrophic activities of BDNF (show BDNF Antibodies).

  6. The data reveal both cell-autonomous and cell-nonautonomous effects, and they imply a central role for Norrin/Fz4 (show FZD4 Antibodies) signaling in central nervous system vascular development and in the maintenance of the blood brain barrier/blood retina barrier state.

  7. Results suggest that the delayed outgrowth of the SRVP and decreased angiogenic sprouting in Norrin knockout (Ndp(y/-)) mice are direct effects of the reduced proliferation of endothelial cells from the superficial retinal vascular plexus (SRVP).

  8. Norrin has a neuroprotective role for retinal neurons independent from its role on the growth of retinal capillaries.

  9. These observations suggest the possibility that Norrin may have developmental and/or homeostatic functions beyond the retina and cochlea.

  10. Norrin has pronounced neuroprotective properties on retinal neurons. The effects of Norrin involve activation of Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) signaling and subsequent induction of neurotrophic growth factors in Muller cells.

Norrie Disease (Pseudoglioma) (NDP) Antigen Profile

Protein Summary

This gene encodes a secreted protein with a cystein-knot motif that activates the Wnt/beta-catenin pathway. The protein forms disulfide-linked oligomers in the extracellular matrix. Mutations in this gene result in Norrie disease and X-linked exudative vitreoretinopathy.

Gene names and symbols associated with NDP

  • Norrie disease (pseudoglioma) (NDP) antibody
  • Norrie disease (pseudoglioma) (ndp) antibody
  • Norrie disease (pseudoglioma) (Ndp) antibody
  • Norrie disease (pseudoglioma) (human) (Ndp) antibody
  • evr2 antibody
  • fevr antibody
  • ND antibody
  • Ndph antibody
  • RGD1563968 antibody
  • xnorrin antibody

Protein level used designations for NDP

X-linked exudative vitreoretinopathy 2 protein , norrie disease protein , norrin , Norrie disease protein , norrie disease protein homolog , Norrie disease homolog

GENE ID SPECIES
4693 Homo sapiens
100301975 Xenopus laevis
418560 Gallus gallus
612440 Canis lupus familiaris
100127357 Sus scrofa
511596 Bos taurus
363443 Rattus norvegicus
17986 Mus musculus
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