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NUCKS1 encodes a nuclear protein that is highly conserved in vertebrates. Additionally we are shipping Nuclear Casein Kinase and Cyclin-Dependent Kinase Substrate 1 Proteins (6) and many more products for this protein.
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Human Polyclonal NUCKS1 Primary Antibody for EIA, FACS - ABIN953772
Satake, Nakabayashi, Mizuta, Hirota, Ito, Kubo, Kawaguchi, Tsunoda, Watanabe, Takeda, Tomiyama, Nakashima, Hasegawa, Obata, Yoshikawa, Kawakami, Sakoda, Yamamoto, Hattori, Murata, Nakamura, Toda: Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease. in Nature genetics 2009
Show all 5 references for ABIN953772
NUCKS1 was identified as a potential oncogene (show RAB1A Antibodies) at chromosomal 1q32.1 in patients with HCC (show FAM126A Antibodies), and it might be a valuable immunodiagnostic marker for HCC (show FAM126A Antibodies)
The results show that NUCKS1 is a chromatin-associated protein with a role in the DNA damage response and in homologous recombination, a DNA repair pathway critical for tumor suppression.
NUCKS is a physiological regulator of energy homeostasis and glucose metabolism that works by regulating chromatin accessibility and RNA polymerase II recruitment to the promoters of IR and other insulin (show INS Antibodies) pathway modulators.
NUCKS1 expression did not increase Tat (show TAT Antibodies) nuclear localization.
NUCKS1 overexpression may be associated with tumour progression and recurrence in cervical squamous cell carcinoma
NUCKS-1 overexpression is associated with obesity and with breast cancer.
We would like to emphasize that NUCKS abundance in malignant skin tumors is higher than that of the well-known proliferation marker Ki67 (show MKI67 Antibodies), thus allowing more precise assessment of tumor proliferation potential.
Authors suggest that NUCKS is involved in cellular responses following PDT (show TWIST1 Antibodies).
The expression of Nucks in both proliferating and quiescent cells and its correlation with Bax (show BAX Antibodies) levels and apoptosis strongly suggest that Nucks plays complex roles in cell homeostasis.
Through a combination of gene expression and copy number analysis, NUCKS1 was identified as a candidate gene involved in the distant metastasis of colorectal cancer.
Hypothalamic NUCKS plays an essential role in regulating glucose homoeostasis and insulin (show INS Antibodies) signaling.
This gene encodes a nuclear protein that is highly conserved in vertebrates. The conserved regions of the protein contain several consensus phosphorylation sites for casein kinase II and cyclin-dependent kinases, two putative nuclear localization signals, and a basic DNA-binding domain. It is phosphorylated in vivo by Cdk1 during mitosis of the cell cycle.
nuclear ubiquitous casein and cyclin-dependent kinases substrate
, nuclear ubiquitous casein kinase and cyclin-dependent kinase substrate
, nuclear casein kinase and cyclin-dependent kinase substrate 1
, nuclear ubiquitous casein and cyclin-dependent kinase substrate
, Nuclear ubiquitous casein and cyclin-dependent kinases substrate
, nuclear ubiquitous casein and cyclin-dependent kinase substrate 1
, potential LAG1 interactor
, nuclear, casein kinase and cyclin-dependent kinase substrate
, cyclin-dependent kinase substrate
, nuclear ubiquitous casein kinase 2