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Nuclear Factor (Erythroid-Derived 2), 45kDa Proteins (NFE2)

Component of the NF-E2 complex essential for regulating erythroid and megakaryocytic maturation and differentiation. Additionally we are shipping NFE2 Antibodies (34) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
NFE2 4778 Q16621
NFE2 18022 Q07279
Rat NFE2 NFE2 366998 Q6AYT2
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Top NFE2 Proteins at

Showing 6 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
Yeast Bacteria His tag   1 mg Log in to see 56 to 66 Days
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
HOST_Human Human Un-conjugated   20 μg Log in to see 19 Days

NFE2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
Mouse (Murine)

More Proteins for Nuclear Factor (Erythroid-Derived 2), 45kDa (NFE2) Interaction Partners

Human Nuclear Factor (Erythroid-Derived 2), 45kDa (NFE2) interaction partners

  1. assessment of NF-E2 and NGFR (show NGFR Proteins) expression may provide additional support in reaching a correct diagnosis in discriminating polycythemia vera (show IGF2BP3 Proteins) from prefibrotic/fibrotic primary myelofibrosis and essential thrombocythemia

  2. The genes BCL6, NFE2, POU4F2 and ELF4 are primary 1,25(OH)2D3 targets in THP-1 cells

  3. the RUNX1 (show RUNX1 Proteins) target NF-E2 is part of the molecular network by which RUNX1 (show RUNX1 Proteins) regulates platelet biogenesis and function in a pedigree with familial platelet disorder with a predisposition to acute myelogenous leukemia

  4. A functional link among the erythroid transcription factors GATA-1 (show GATA1 Proteins)/NF-E2, miR (show MLXIP Proteins)-199b-5p in erythropoiesis.

  5. NF-E2 immunohistochemistry and analysis of the proportion of nuclear positive erythroblasts of all erythroid precursor cells can help to distinguish between ET and PMF (show PRB1 Proteins) even in early stages of the diseases.

  6. NFE-2 transgene mediates the expression of interleukin 8 (show IL8 Proteins) in myeloproliferative neoplasms, thereby contributing to myeloproliferative neoplasm pathology.

  7. Findings suggest a model whereby ROCK inhibition drives polyploidization, DMS growth and proplatelet formation late in megakaryocyte maturation through downregulation of MYC (show MYC Proteins) and NFE2 expression.

  8. IFN-gamma modulates NF-kappaB/c-Jun to antagonize activin A-mediated NF-E2 transcriptional activity on erythroid cell globin gene expression.

  9. RUNX1 (show RUNX1 Proteins) and NF-E2 are overexpressed in polycythemic patients of diverse phenotypes and molecular causes

  10. Here we demonstrate that NF-E2 is mislocalized in prefibrotic primary myelofibrosis cells and that aberrant NF-E2 localization discriminates statistically highly significantly between essential thrombocytthemia and that disease.

Mouse (Murine) Nuclear Factor (Erythroid-Derived 2), 45kDa (NFE2) interaction partners

  1. A novel murine model may excellently describe the deleterious impact of sustained chronic NF-E2 overexpression during uncontrolled chronic inflammation upon the hematopoietic system--the development of clonal myeloproliferation.

  2. Although none of the parameters measured were different between the NF-E2 deficient and control mice, an increase in calcium (21%) and an increase in the mineral/matrix ratio (32%) was observed in GATA-1 (show GATA1 Proteins) deficient mice.

  3. By activating genes in megakaryocytes that mediate platelet production and function, NF-E2 p45 determines the quantity and quality of platelets.

  4. maintaining expression of intestinal epithelial cell prohibitin (show PHB Proteins) reduces the severity of inflammation and increases colonic levels of the antioxidants HO-1 (show HMOX1 Proteins) and NQO-1 (show NQO1 Proteins) via a mechanism independent of Nfe2

  5. These findings demonstrate that a combination of p45NF-E2, Maf (show MAF Proteins) G, and Maf (show MAF Proteins) K is a key determinant of both megakaryopoiesis and thrombopoiesis.

  6. Loss of p45 NF-E2 leads to a 2-fold increase in serum erythropoietin (show EPO Proteins) & increased splenic erythropoiesis. Erythroid cells were arrested at the G(1) stage of cell cycle.

  7. Nfe2 modulates JunD (show JUND Proteins) binding to the Gcm1 (show GCM1 Proteins) promoter via acetylation

  8. studies identify a novel function of p45NF-E2 during placental development: in trophoblast cells, p45NF-E2 represses Gcm1 (show GCM1 Proteins) and syncytiotrophoblast formation via acetylation

  9. NLS (show ALDH1A2 Proteins)-dependent nuclear import of p45 NF-E2 is important for platelet development

  10. USF and NF-E2 cooperate to regulate the recruitment and activity of RNA polymerase II in the beta-globin (show HBB Proteins) gene locus.

NFE2 Protein Profile

Protein Summary

Component of the NF-E2 complex essential for regulating erythroid and megakaryocytic maturation and differentiation. Binds to the hypersensitive site 2 (HS2) of the beta-globin control region (LCR). This subunit (NFE2) recognizes the TCAT/C sequence of the AP-1-like core palindrome present in a number of erythroid and megakaryocytic gene promoters. Requires MAFK or other small MAF proteins for binding to the NF-E2 motif. May play a role in all aspects of hemoglobin production from globin and heme synthesis to procurement of iron.

Gene names and symbols associated with NFE2

  • nuclear factor (erythroid-derived 2), 45kDa (NFE2)
  • nuclear factor, erythroid 2 (NFE2)
  • nuclear factor, erythroid derived 2 (Nfe2)
  • 45kDa protein
  • NF-E2 protein
  • p45 protein
  • p45nf-e2 protein
  • p45NFE2 protein

Protein level used designations for NFE2

leucine zipper protein NF-E2 , nuclear factor, erythroid derived 2 , nuclear factor, erythroid-derived 2 45 kDa subunit , p45 NF-E2 , transcription factor NF-E2 45 kDa subunit , nuclear factor (erythroid-derived 2), 45kD , nuclear factor (erythroid-derived 2), 45kDa , nuclear factor, erythroid derived 2, 45 kDa

486495 Canis lupus familiaris
514006 Bos taurus
4778 Homo sapiens
18022 Mus musculus
366998 Rattus norvegicus
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