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The protein encoded by MLZE is a transcription factor that binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3 in viral and cellular promoters. Additionally we are shipping Nuclear Factor I/X Antibodies (26) and Nuclear Factor I/X Kits (3) and many more products for this protein.
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The data indicate that NFIX influences the lineage specification of postnatal subventricular zone neural stem cells, specifically suppressing oligodendrogenesis.
The ependymal layer of the lateral ventricles was frequently absent in Nfix(-/-) mice
NFIX acts as a regulator of lineage specification in the haematopoietic system.
NFIX plays a central role in hippocampal morphogenesis, regulating the formation of neuronal and glial populations within this
Bbx (show BBX Proteins) is a downstream target of NFIX during development of the forebrain.
The findings demonstrate that the level of Nfix expression during development and within the adult is essential for the function of the hippocampus during learning and memory.
Nfix is a novel regulator of murine hematopoietic stem and progenitor cell survival.
NFIX is robustly induced when neural stem cells enter quiescence
During vertebrate evolution, the transcription factor Nfix lost some specific functions, probably as a consequence of the different environment in which teleosts and mammals develop.
The development of cerebellar granule neurons and Purkinje cells within the postnatal cerebellum is delayed in NFIX knock-out mice.
Report novel mutations of NFIX gene causing Marshall-Smith syndrome or Sotos-like syndrome.
miR (show MLXIP Proteins)-1290 functions as a tumor oncogene (show RAB1A Proteins) in the progression of esophageal squamous cell carcinoma by targeting NFIX
NFIX analysis should be considered in patients presenting with overgrowth, macrocephaly and developmental delay including those in whom Sotos syndrome has been considered clinically but are negative for pathogenic NSD1 variants.
TGF-beta (show TGFB1 Proteins)-mediated suppression of ANT2 (show SLC25A5 Proteins) through NF1 (show NF1 Proteins)/Smad4 (show SMAD4 Proteins) complexes contributes to oxidative stress and DNA damage during induction of cellular senescence.
Deletions in the 3' part of the NFIX gene including a recurrent Alu-mediated deletion of exon 6 and 7 account for previously unexplained cases of Marshall-Smith syndrome.
missense mutations in NFIX were able to cause Sotos-like features.
DNA methylation (show HELLS Proteins) shows genome-wide association of NFIX, RAPGEF2 (show RAPGEF2 Proteins) and MSRB3 (show MSRB3 Proteins) with gestational age at birth.
NFI (show NFIC Proteins)-X3 and STAT3 (show STAT3 Proteins) control the migration of differentiating astrocytes as well as migration and invasion of glioma cells via regulating YKL-40 (show CHI3L1 Proteins) expression.
NFI-X3 activates GFAP expression, in part, by inducing alterations in the nucleosome architecture that lead to the increased recruitment of RNA polymerase II
These findings demonstrate that allelic NFIX mutations trigger distinct phenotypes, depending specifically on their impact on nonsense-mediated mRNA decay.
NFIX had highest expression in brain; medial expression in lung and muscle; and lower expression in spleen, kidney, liver and heart of both embryo and adult cattle. However, expression levels in adult tissues were significantly decreased.
Two sequence variants of the Nfix gene are significantly associated with growth traits at different ages.
CCAAT box binding transcription factor (show NFIA Proteins) (NF-Y) B (show NFYB Proteins) is a critical modulator of neural crest cell's gene expression governing embryonic cartilage growth
The protein encoded by this gene is a transcription factor that binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3 in viral and cellular promoters. The encoded protein can also stimulate adenovirus replication in vitro. Three transcript variants encoding different isoforms have been found for this gene.
CCAAT-box-binding transcription factor
, TGGCA-binding protein
, nuclear factor 1 X-type
, nuclear factor 1/X
, NF1-X1 protein
, nuclear factor I-X protein
, Nuclear factor 1/X