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In T-helper 2 (Th2) cells, regulates the magnitude of NFAT-driven transcription of a specific subset of cytokine genes, including IL3, IL4, IL5 and IL13, but not IL2. Additionally we are shipping Nuclear Factor of Activated T-Cells, Cytoplasmic, Calcineurin-Dependent 2 Interacting Protein Antibodies (21) and Nuclear Factor of Activated T-Cells, Cytoplasmic, Calcineurin-Dependent 2 Interacting Protein Proteins (6) and many more products for this protein.
results indicate that RANKL (show TNFSF11 ELISA Kits) signaling down regulates NIP45 expression and that NIP45 is a negative regulator of osteoclast differentiation
This finding highlights a possible role of the RENi proteins in the modulation of Ubc9-mediated poly-SUMO formation.
NIP45 promotes robust cytokine expression in vivo, which is required for the efficient handling of parasites, acting as a molecular rheostat serving to amplify the type-2 immune response.
Data report a role for arginine methylation of NIP45 in regulating cytokine gene transcription in the T helper lymphocyte.
TRAF1 (show TRAF1 ELISA Kits) limit the induction of Th2 responses by decreasing NIP45 concentration to the nucleus down-regulating the expression of NIP45-dependent IL-4 (show IL4 ELISA Kits) gene transcription.
ZBTB25 functions as a negative regulator of nuclear factor of activated T cells (NF-AT (show NFATC3 ELISA Kits)) activation, such that RNA interference mediated knockdown resulted in enhanced activation of target genes.
In T-helper 2 (Th2) cells, regulates the magnitude of NFAT-driven transcription of a specific subset of cytokine genes, including IL3, IL4, IL5 and IL13, but not IL2. Recruits PRMT1 to the IL4 promoter\; this leads to enhancement of histone H4 'Arg-3'- methylation and facilitates subsequent histone acetylation at the IL4 locus, thus promotes robust cytokine expression. Down- regulates formation of poly-SUMO chains by UBE2I/UBC9.
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 interacting protein
, NFATC2-interacting protein
, 45 kDa NF-AT-interacting protein
, 45 kDa NFAT-interacting protein
, nuclear factor of activated T-cells, cytoplasmic 2 interacting protein
, nuclear factor of activated T-cells, cytoplasmic 2-interacting protein