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Could participate in the response to proapoptotic stimuli and promotes cellular growth in a way that helps the tissue counteract diverse injuries. Additionally we are shipping Nuclear Protein, Transcriptional Regulator, 1 Antibodies (45) and Nuclear Protein, Transcriptional Regulator, 1 Proteins (4) and many more products for this protein.
Nupr1 acts as a gene modifier of the effect of Kras(G12D)-induced senescence by regulating Dnmt1 (show DNMT1 ELISA Kits) expression and consequently genome-wide levels of DNA methylation (show HELLS ELISA Kits).
Hepatitis B virus X (HBx) protein can modulate NUPR1 expression through the Smad4 pathway and NUPR1 has a role in hepatocellular carcinoma progression.
Data indicate that heat shock protein 70 (Hsp70) is higher in nuclear protein 1 (Nupr1+/-) haplodeficient mice, concomitant with improved insulin sensitivity.
Nupr1 aids oncogenic Kras to bypass senescence in a manner that cooperatively promotes pancreas intraepithelial neoplasia formation.
data shows that p8 deficiency increases ROS (show ROS1 ELISA Kits) and subsequently the expression of anti-oxidative enzymes, such as HO-1 (show HMOX1 ELISA Kits), suggesting an involvement in the anti-oxidative defense.
According to Nupr1 status, KIC mice develop tumours that phenocopy human classical or QM-PDAC, respectively, and present differential drug sensitivity, thus becoming attractive models for preclinical drug trials.
Nupr1 expression is required for IL-1beta-mediated expression of MMP-13. (show MMP13 ELISA Kits)
Inhibition of NUPR1 expression or activity has the potential to protect against the metabolic defects associated with obesity and type 2 diabetes.
a NUPR1/RELB/IER3 stress-related pathway that is required for oncogenic Kras(G12D)-dependent transformation of the pancreas.
progressive PPARalpha (show PPARA ELISA Kits)- and p8-mediated ER stress contribute to the hepatocarcinogenesis in ACOX1 (show ACOX1 ELISA Kits)(-/-) mice
findings suggest that local interactions and hydrophobic effects play a major role in determining the electrostatic features of NUPR1, whereas long-range charge contributions appear to be of lesser importance.
Mitochondrial respiratory defects and subsequent retrograde signaling, particularly the NUPR1-granulin (show GRN ELISA Kits) pathway, play pivotal roles in liver cancer progression
Functional characterization of NUPR1L as a new p53-induced gene, which negatively regulates the protumoral factor NUPR1.
Knockdown of Nupr1 inhibited the proliferation and migration of HepG2 hepatocellular carcinoma cells
NUPR1 has been conserved throughout evolution, and over time it has undergone duplications and transpositions to form other transcriptional regulators.
Increase of NUPR1 protein expression is associated with endometrial cancer invasion.
P8 and MEG3 mRNA levels were significantly lower in nonfunctioning and corticotroph adenomas compared with normal pituitary.
The Nupr1 protein bound to chemically-damaged-DNA with a slightly larger affinity (0.4 microM), but in an enthalpically-driven process. Nupr1 showed different interacting regions in the formed complexes with Nupr1 or DNA
Could participate in the response to proapoptotic stimuli and promotes cellular growth in a way that helps the tissue counteract diverse injuries. May contribute to the metastatic phenotype.
nuclear protein 1
, protein p8
, candidate of metastasis 1
, p8 protein
, nuclear protein, transcriptional regulator, 1