Nuclear RNA Export Factor 1 Proteins (NXF1)

NXF1 is one member of a family of nuclear RNA export factor genes. Additionally we are shipping NXF1 Antibodies (59) and NXF1 Kits (23) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
NXF1 10482 Q9UBU9
NXF1 53319 Q99JX7
NXF1 59087 O88984
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Top NXF1 Proteins at

Showing 5 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
Yeast Rat His tag   1 mg Log in to see 60 to 71 Days
HOST_Escherichia coli (E. coli) Rat T7 tag,His tag   100 μg Log in to see 15 to 18 Days

NXF1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
Mouse (Murine)

Rat (Rattus) ,

More Proteins for Nuclear RNA Export Factor 1 (NXF1) Interaction Partners

Human Nuclear RNA Export Factor 1 (NXF1) interaction partners

  1. small hairpin RNA-mediated down-regulation of TAP or Aly (show THOC4 Proteins) reduced nuclear export of HDAg-L and assembly of HDV virions. Furthermore, a peptide, TAT (show TAT Proteins)-HDAg-L(198-210), containing the 10-amino acid TAT (show TAT Proteins) peptide and HDAg-L(198-210), inhibited the interaction between HDAg-L and TAP and blocked HDV virion assembly and secretion.

  2. Hepatitis B virus core protein associates with the cellular NXF1-p15 (show CDKN2B Proteins) complex via the nuclear export signal motif of hepatitis B virus core protein.Nuclear export of human hepatitis B virus core protein and pregenomic RNA depends on the NXF1-p15 (show CDKN2B Proteins) machinery.

  3. Complementary structural, biochemical and cellular techniques indicated that the formation of a symmetric RNA binding platform generated by dimerization of NXF1:NXT1 (show NXT1 Proteins) facilitates the recognition of CTE-RNA and promotes its nuclear export

  4. Gag polyprotein synthesis was decreased by NXF1 knockdown.

  5. a spatial map is produced in living cells of the sites for the interaction of two TREX subunits, Alyref (show THOC4 Proteins) and Chtop (show CHTOP Proteins), with Nxf1.

  6. TREX is the major complex used to recruit Nxf1 to mRNA in human cells.

  7. the organization of the NXF1 proline-tyrosine nuclear localization signal reveal unexpected redundancy in the nuclear import pathways used by NXF1.

  8. The U2AF65 protein ser (show U2AF59 Proteins)ved as an adaptor to link expanded CAG RNA to NXF1 for RNA export.

  9. these data revealed a redox-regulated chaperone function of PDI in delivering antigenic peptides from TAP to MHC-I.

  10. Tpr plays an important role in quality control of mRNA trafficked on the Nxf1 pathway.

Mouse (Murine) Nuclear RNA Export Factor 1 (NXF1) interaction partners

  1. Taken together, the results show for the first time that murine leukemia virus requires the Tap/NXF1-mediated export pathway for the expression of its spliced and unspliced RNAs and for full-legth RNA nuclear export.

  2. Disruption of NXF1 expression impaired cytoplasmic accumulations of both spliced and unspliced RNA transcripts of Murine leukemia virus.

  3. Perturbation of U2AF65 (show U2AF59 Proteins)/NXF1-mediated RNA nuclear export enhances RNA toxicity in polyQ diseases.

  4. RNA transport element RTE evolved as a high affinity RBM15 ligand to provide a splicing-independent link to NXF1, thereby ensuring efficient nuclear export and expression of retrotransposon transcripts

  5. FMRP (show FMR1 Proteins) and Nxf2 (show NXF2 Proteins) associate with and destabilize Nxf1 mRNA in neuronal cells.

  6. CAST allele of Nxf1 suppresses IAP (show ALPI Proteins)-Idelta1 insertions in Ap3d1[mh2J], Atcay (show ATCAY Proteins)[hes (show ATCAY Proteins)], Mgrn1 (show MGRN1 Proteins)[md] and Usp14[axJ]. Does not suppress the Mitf (show MITF Proteins)[mi-bw (show MITF Proteins)] LINE nor any of six tested ETn insertion alleles.

  7. The RNA-binding motif protein 15B (RBM15B/OTT3) acts as cofactor of the nuclear export receptor NXF1.

  8. Allelic variation in Nxf1 suppresses RNA processing defects in IAP (show ALPI Proteins) insertion alleles of Pitpn (vibrator (show PITPNA Proteins)) and Eya1 (show EYA1 Proteins) (branchio-oto (show PGAP1 Proteins)-renal syndrome).

NXF1 Protein Profile

Protein Summary

This gene is one member of a family of nuclear RNA export factor genes. Common domain features of this family are a noncanonical RNP-type RNA-binding domain (RBD), 4 leucine-rich repeats (LRRs), a nuclear transport factor 2 (NTF2)-like domain that allows heterodimerization with NTF2-related export protein-1 (NXT1), and a ubiquitin-associated domain that mediates interactions with nucleoporins. The LRRs and NTF2-like domains are required for export activity. Alternative splicing seems to be a common mechanism in this gene family. The encoded protein of this gene shuttles between the nucleus and the cytoplasm and binds in vivo to poly(A)+ RNA. It is the vertebrate homologue of the yeast protein Mex67p. The encoded protein overcomes the mRNA export block caused by the presence of saturating amounts of CTE (constitutive transport element) RNA of type D retroviruses. Alternative splicing results in multiple transcript variants.

Gene names and symbols associated with NXF1

  • nuclear RNA export factor 1 (nxf1)
  • nuclear RNA export factor 1 (NXF1)
  • nuclear RNA export factor 1 (sbr)
  • nuclear RNA export factor 1 (Tsp_03999)
  • nuclear RNA export factor 1 (Nxf1)
  • Protein NXF-1 (nxf-1)
  • im:7156527 protein
  • Mex67 protein
  • Mex67h protein
  • MGC82224 protein
  • Mvb1 protein
  • NXF1 protein
  • Tap protein
  • wu:fc12d06 protein

Protein level used designations for NXF1

nuclear RNA export factor 1 , small bristles , Nuclear RNA export factor 1 , nuclear RNA export factor 1-like , mRNA export factor TAP , tip associating protein , tip-associated protein , tip-associating protein , Mex 67 homolog , modifier of vibrator 1 , nuclear RNA export factor 1 homolog , tip associated protein

323865 Danio rerio
432035 Xenopus laevis
451267 Pan troglodytes
734058 Xenopus (Silurana) tropicalis
100049009 Equus caballus
100113601 Nasonia vitripennis
100380454 Salmo salar
100399719 Callithrix jacchus
10904254 Trichinella spiralis
10482 Homo sapiens
483780 Canis lupus familiaris
512136 Bos taurus
53319 Mus musculus
59087 Rattus norvegicus
100347351 Oryctolagus cuniculus
100628213 Sus scrofa
769691 Gallus gallus
101115327 Ovis aries
100728879 Cavia porcellus
191736 Caenorhabditis elegans
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