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NXF3 is one member of a family of nuclear RNA export factor genes. Additionally we are shipping NXF3 Antibodies (44) and many more products for this protein.
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Mechanistic insights into the roles of NXF3 are implicated in transforming growth factor (TGF)-beta (show TGFB1 Proteins)-mediated expression of Tgfbeta3 and other genes.
The Nxf3 is expressed exclusively in Sertoli cells of the postnatal testis, in a developmentally regulated manner.
This gene is one member of a family of nuclear RNA export factor genes. Common domain features of this family are a noncanonical RNP-type RNA-binding domain (RBD), 4 leucine-rich repeats (LRRs), a nuclear transport factor 2 (NTF2)-like domain that allows heterodimerization with NTF2-related export protein-1 (NXT1), and a ubiquitin-associated domain that mediates interactions with nucleoporins. The LRRs and NTF2-like domains are required for export activity. Alternative splicing seems to be a common mechanism in this gene family. The encoded protein of this gene has shortened LRR and ubiquitin-associated domains and its RDB is unable to bind RNA. It is located in the nucleoplasm but is not associated with either the nuclear envelope or the nucleolus.
nuclear RNA export factor 3
, nuclear RNA export factor 3-like
, TAP-like protein 3