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Nuclear Receptor Binding SET Domain Protein 1 (NSD1) ELISA Kits

NSD1 encodes a protein containing a SET domain, 2 LXXLL motifs, 3 nuclear translocation signals (NLSs), 4 plant homeodomain (PHD) finger regions, and a proline-rich region. Additionally we are shipping NSD1 Antibodies (41) and and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
Anti-Human NSD1 NSD1 64324 Q96L73
Anti-Rat NSD1 NSD1 306764  
Anti-Mouse NSD1 NSD1 18193  
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More ELISA Kits for NSD1 Interaction Partners

Human Nuclear Receptor Binding SET Domain Protein 1 (NSD1) interaction partners

  1. Studies indicate that the NSD methyltransferases NSD1, NSD2/WHSC1/MMSET (show WHSC1 ELISA Kits) and NSD3/WHSC1L1 (show WHSC1L1 ELISA Kits) were overexpressed, amplified or somatically mutated in multiple types of cancer, suggesting their critical role in cancer.

  2. The genome-wide impact of a highly significant NSD1(+/-)-specific signature that differentiates pathogenic NSD1 mutations from controls, benign NSD1 variants and the clinically overlapping Weaver (show KCNJ6 ELISA Kits) syndrome is described.

  3. The results describe the binding of NSD1, 2 and 3 catalytic domains CD) on histone tails through recognition of histone-lysine and methylation properties.

  4. NSD1 interacted with RNAPII and bound to GSTM3 (show glutathione S-transferase mu 3 (brain) ELISA Kits) -63A/C TATA box.

  5. Acute myeloid leukemia (show BCL11A ELISA Kits) can be reproduced in mice by transducing mouse mesenchymal stem cells with the human NUP98 (show NUP98 ELISA Kits)-NSD1 fusion and the FLT3 (show FLT3 ELISA Kits)-ITD mutated constracts.

  6. This report describes, for the first time, a Korean family with two generations of Stotos syndrome resulting from a novel intragenic NSD1 mutation.

  7. NSD1 prefers aromatic, hydrophobic, and basic residues at the -2, -1 and +2, and +1 sites of its substrate peptide in histone H3 (show HIST3H3 ELISA Kits).

  8. support to the adoption of screening for NUP98 (show NUP98 ELISA Kits)-NSD1 in pediatric AML (show RUNX1 ELISA Kits) without otherwise favorable genetic markers

  9. all of the H3K36-specific methyltransferases, including ASH1L (show ASH1L ELISA Kits), HYPB, NSD1, and NSD2 (show WHSC1 ELISA Kits) were inhibited by ubH2A, whereas the other histone methyltransferases, including PRC2, G9a (show EHMT2 ELISA Kits), and Pr-Set7 (show SETD8 ELISA Kits) were not affected by ubH2A.

  10. NSD1 mutations that cause Sotos syndrome are loss-of-function, primarily truncating mutations or missense mutations at key residues in functional domains. EZH2 (show EZH2 ELISA Kits) mutations that cause Weaver (show KCNJ6 ELISA Kits) syndrome are primarily missense variants

Mouse (Murine) Nuclear Receptor Binding SET Domain Protein 1 (NSD1) interaction partners

  1. Silencing of Nsd1 followed by LLO stimulation led to increased caspase-1 (show CASP1 ELISA Kits) activation, enhanced post-translational maturation of IL-1beta (show IL1B ELISA Kits) and IL-18 (show IL18 ELISA Kits) and elevated pyroptosis, a form of cell death associated with inflammation.

  2. Nsd1 contains consensus TFII-I (show GTF2I ELISA Kits) binding sites in the proximal promoters; the chromatin immunoprecipitation analysis showed that TFII-I (show GTF2I ELISA Kits) transcription factors are recruited to these sites in vivo in Williams-Beuren syndrome.

  3. all of the H3K36-specific methyltransferases, including ASH1L (show ASH1L ELISA Kits), HYPB, NSD1, and NSD2 (show WHSC1 ELISA Kits) were inhibited by ubH2A, whereas the other histone methyltransferases, including PRC2, G9a (show EHMT2 ELISA Kits), and Pr-Set7 (show SETD8 ELISA Kits) were not affected by ubH2A.

  4. NSD1 interaction with liganded NRs (show SPNS1 ELISA Kits) including ERa, AR, RARa (show RARA ELISA Kits), RXRa (show RXRA ELISA Kits), TRb (show AATF ELISA Kits), PPARg (show PPARG ELISA Kits) and VDR (show CYP27B1 ELISA Kits) is mediated by an LXXLL motif. Interaction with the NR2E/F subfamily including COUP-TFI (show NR2F1 ELISA Kits), COUP-TFII (show NR2F2 ELISA Kits), EAR2 (show NR2F6 ELISA Kits) and TLX (show NR2E1 ELISA Kits) requires an overlapping F/YSXXLXXL/Y motif.

  5. Data show that nuclear receptor-binding SET domain-containing protein (NSD1) is a developmental regulatory protein with histone methyltransferase activity that exerts function(s) essential for early post-implantation development.

  6. Nizp1 contains a novel type of zinc finger motif that functions as a docking site for NSD1

NSD1 Antigen Profile

Antigen Summary

This gene encodes a protein containing a SET domain, 2 LXXLL motifs, 3 nuclear translocation signals (NLSs), 4 plant homeodomain (PHD) finger regions, and a proline-rich region. The encoded protein enhances androgen receptor (AR) transactivation, and this enhancement can be increased further in the presence of other androgen receptor associated coregulators. This protein may act as a nucleus-localized, basic transcriptional factor and also as a bifunctional transcriptional regulator. Mutations of this gene have been associated with Sotos syndrome and Weaver syndrome. One version of childhood acute myeloid leukemia is the result of a cryptic translocation with the breakpoints occurring within nuclear receptor-binding Su-var, enhancer of zeste, and trithorax domain protein 1 on chromosome 5 and nucleoporin, 98-kd on chromosome 11. Two transcript variants encoding distinct isoforms have been identified for this gene.

Gene names and symbols associated with NSD1

  • nuclear receptor binding SET domain protein 1 (NSD1) antibody
  • nuclear receptor binding SET domain protein 1 (nsd1) antibody
  • nuclear receptor binding SET domain protein 1 (LOC100355926) antibody
  • nuclear receptor binding SET domain protein 1 (Nsd1) antibody
  • nuclear receptor-binding SET-domain protein 1 (Nsd1) antibody
  • AI528500 antibody
  • ARA267 antibody
  • KMT3B antibody
  • NSD1 antibody
  • SOTOS antibody
  • SOTOS1 antibody
  • STO antibody

Protein level used designations for NSD1

nuclear receptor binding SET domain protein 1 , histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific-like , H3-K36-HMTase , H4-K20-HMTase , NR-binding SET domain-containing protein , androgen receptor coactivator 267 kDa protein , androgen receptor-associated coregulator 267 , androgen receptor-associated protein of 267 kDa , histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific , lysine N-methyltransferase 3B , nuclear receptor-binding SET domain-containing protein 1

GENE ID SPECIES
416214 Gallus gallus
471754 Pan troglodytes
706131 Macaca mulatta
100058570 Equus caballus
100145675 Xenopus (Silurana) tropicalis
100355926 Oryctolagus cuniculus
100461473 Pongo abelii
100477428 Ailuropoda melanoleuca
100538695 Meleagris gallopavo
64324 Homo sapiens
306764 Rattus norvegicus
489094 Canis lupus familiaris
100524976 Sus scrofa
540197 Bos taurus
18193 Mus musculus
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