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Nuclear Receptor Coactivator 1 Proteins (NCOA1)

The protein encoded by NCOA1 acts as a transcriptional coactivator for steroid and nuclear hormone receptors. Additionally we are shipping NCOA1 Antibodies (100) and NCOA1 Kits (5) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
NCOA1 8648 Q15788
NCOA1 17977 P70365
Rat NCOA1 NCOA1 313929  
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Top NCOA1 Proteins at antibodies-online.com

Showing 7 out of 9 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Baculovirus infected Insect Cells Human Un-conjugated 100 μg Log in to see 2 to 3 Days
$4,173.75
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 to 54 Days
$13,567.94
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 to 54 Days
$13,567.94
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Sf-9 cells Human Un-conjugated   5 μg Log in to see 3 to 4 Days
$571.07
Details
HOST_Sf-9 Cells Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$460.85
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

NCOA1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , , ,
,
Mouse (Murine)

More Proteins for Nuclear Receptor Coactivator 1 (NCOA1) Interaction Partners

Xenopus laevis Nuclear Receptor Coactivator 1 (NCOA1) interaction partners

  1. The structural and functional competency of the UPIII (show UPK3A Proteins)-Src (show SRC Proteins) signaling system in membrane microdomains is strictly regulated during oocyte maturation.

Human Nuclear Receptor Coactivator 1 (NCOA1) interaction partners

  1. NCOA1 potentiates breast cancer angiogenesis through upregulating HIF1alpha (show HIF1A Proteins) and AP-1 (show FOSB Proteins)-mediated VEGFa (show VEGFA Proteins) expression

  2. miR (show MLXIP Proteins)-137 has a role in targeting p160 (show MSH6 Proteins) steroid receptor (show ESR2 Proteins) coactivators SRC1 (show SRC Proteins), SRC2 (show NCOA2 Proteins), and SRC3 (show NCOA3 Proteins) and inhibits cell proliferation

  3. Report novel PAX3 (show PAX3 Proteins)-NCOA1 gene fusions in biphenotypic sinonasal sarcomas with focal rhabdomyoblastic differentiation.

  4. Data indicate that finerenone inhibits mineralocorticoid receptor (show NR3C2 Proteins) (MR), steroid receptor coactivator-1 binding at the regulatory sequence.

  5. Data suggest that over-stimulating the steroid seceptor coactivators SRC-1 (show SRC Proteins), SRC-2 (show NCOA2 Proteins), and SRC-3 (show NCOA3 Proteins) oncogenic program can be an effective strategy to kill cancer cells.

  6. Our study clearly demonstrated differentiation-dependant expression of SRC-1 (show SRC Proteins) and SRC-3 (show NCOA3 Proteins) in chondrosarcoma

  7. SRC-1 (show SRC Proteins) polymorphisms may be the underlying cause of coronary artery aneurysms in children with Kawasaki disease.

  8. Data show that disrupting the steroid receptor coactivator-1 (SRC1) binding site on retinoid X receptor alpha (RXRalpha (show RXRA Proteins)) alters the transactivation by CAR:RXR.

  9. NCOA1 plays a necessary role in E2-induced CXCL12 (show CXCL12 Proteins) expression and NCOA2 (show NCOA2 Proteins) is required for P4 to inhibit the E2-induced CXCL12 (show CXCL12 Proteins) production in normal and ectopic endometrium.

  10. SRC1 (show SRC Proteins) and Twist1 (show TWIST1 Proteins) expression are associated with poor survival in breast cancer.

Mouse (Murine) Nuclear Receptor Coactivator 1 (NCOA1) interaction partners

  1. SRC-1/3 are required for cardiomyocyte proliferation and differentiation at earlier developmental stages, and their dysfunction causes NCC (show SLC12A3 Proteins)-like abnormalities in the hearts of newborn and adult mice.

  2. While hippocampal SRC-1 was significantly downregulated by orchidectomy (ORX), its expression was rescued by treatment with testosterone in a dose-dependent manner. Testosterone regulates synaptic proteins involves AR, estrogen receptors and SRC-1.

  3. fetal lungs produce signals to initiate labor when mature, and SRC-1/-2-dependent production of SP-A (show SFTPA1 Proteins) and PAF (show KIAA0101 Proteins) is crucial for this process

  4. Consequently, SRC-1 null mice displayed low TAT (show TAT Proteins) expression and presented with hypertyrosinemia and corneal alterations, 2 clinical features observed in the human syndrome of TAT (show TAT Proteins) deficiency.

  5. the effect of orchidectomy (ORX) on the expression of SRC-1

  6. Letrozole induces dramatic decrease of SRC-1 in the medial septal, hippocampus, medial habenular nucleus, arcuate hypothalamic nucleus and superior colliculus.

  7. SRC1 regulates anxiety responses in male and female mice.

  8. IRS1 (show IRS1 Proteins) levels are significantly increased in mouse cell lines representing fat and muscle lineages with p/CIP (show NCOA3 Proteins) and SRC-1 deletions and in white adipose tissue and skeletal muscle of knockout mice.

  9. The effects of gonadectomy on the expression of SRC-1 suggest a distinct regulatory mode between female and male gonad hormones in the regulation of hippocampal SRC-1 protein.

  10. A previously unidentified 70-kDa SRC-1 proteolytic isoform is highly elevated both in the endometriotic tissue of mice with endometriosis and in endometriotic stromal cells biopsied from patients with endometriosis.

Pig (Porcine) Nuclear Receptor Coactivator 1 (NCOA1) interaction partners

  1. we cloned and sequenced full length cDNA of NCOA-1 gene in pig. The putative protein includes 1440 amino acids. Sequences alignment showed that pig NCOA-1 gene cDNA sequence has identity of 93.73% with human and mouse.

Fruit Fly (Drosophila melanogaster) Nuclear Receptor Coactivator 1 (NCOA1) interaction partners

  1. Src64 controls actin dynamics to mediate proper ring canal formation during incomplete cytokinesis during germline cyst development in vivo

  2. that Brat represses the translation of src64B, an upstream regulator of a conserved Rho-dependent pathway previously shown to promote axon retraction

  3. Results show that Src42a and Src64b are required for the normal division capacity of Drosophila intestinal progenitor cells, and that these genes as well as Ack cause progenitor overproliferation in the intestine via core cell cycle activation.

  4. a novel essential role for Src (show SRC Proteins) in intestinal stem/progenitor cell proliferation and tumourigenesis initiation in vivo.

  5. Data show that the actin-Capping Protein (show TMOD4 Proteins) (CP) alphabeta heterodimer, which regulates actin (show ACTB Proteins) filament (F-actin (show ACTB Proteins)) polymerization, limits Src (show SRC Proteins)-induced apoptosis or tissue overgrowth by restricting JNK (show MAPK8 Proteins) activation.

  6. Dumbfounded/Neph1 (show NEPH1 Proteins), a key diaphragm constituent, is a target of the Src kinase (show CSK Proteins) Src64B. Loss of Src64B activity leads to a reduction in the number of diaphragms, and this effect is in part mediated by loss of Dumbfounded/Neph1 (show NEPH1 Proteins) tyrosine phosphorylation.

  7. Homodimerization of the Wnt receptor DERAILED recruits the Src (show SRC Proteins) family kinase SRC64B in the developing embryonic central nervous system.

  8. E4orf4 has a role in inducing PP2A (show PPP2R2B Proteins)- and Src (show SRC Proteins)-dependent cell death while inhibiting classic apoptosis pathways in Drosophila melanogaster

  9. Mutations in a Drosophila src gene, src64, that alter the three HRD amino acids, were identified.

  10. Src64B overexpression induced the formation of specialized haemocytes (lamellocytes), but had no effect on circulating plasmatocyte concentration. Src64B overexpression induced F-actin (show ACTB Proteins) formation and Jun kinase (show MAPK9 Proteins) activation in plasmatocytes.

NCOA1 Protein Profile

Protein Summary

The protein encoded by this gene acts as a transcriptional coactivator for steroid and nuclear hormone receptors. It is a member of the p160/steroid receptor coactivator (SRC) family and like other family members has histone acetyltransferase activity and contains a nuclear localization signal, as well as bHLH and PAS domains. The product of this gene binds nuclear receptors directly and stimulates the transcriptional activities in a hormone-dependent fashion. Alternatively spliced transcript variants encoding different isoforms have been identified.

Gene names and symbols associated with NCOA1

  • nuclear receptor coactivator 1 (NCOA1)
  • nuclear receptor coactivator 1 (ncoa1)
  • steroid receptor RNA activator 1 (sra1)
  • steroid receptor RNA activator 1 (SRA1)
  • steroid receptor RNA activator 1 (LOC100345921)
  • nuclear receptor coactivator 1 (Ncoa1)
  • Src oncogene at 64B (Src64B)
  • v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (src-b)
  • bHLHe42 protein
  • bHLHe74 protein
  • c-src protein
  • C-src1 protein
  • CG7524 protein
  • csrc protein
  • D-src protein
  • D-Src64B protein
  • DKFZp459C083 protein
  • Dmel\CG7524 protein
  • DmHD-358 protein
  • Dm SRC1 protein
  • dsrc protein
  • Dsrc64 protein
  • Dsrc64B protein
  • F-SRC-1 protein
  • HD-358 protein
  • KAT13A protein
  • MGC128615 protein
  • MRE5 protein
  • NCOA1 protein
  • pp60c-src protein
  • pp60v-src protein
  • RIP160 protein
  • si:dkey-5g7.6 protein
  • si:dkey-34f16.6 protein
  • SRA1 protein
  • src protein
  • src-1 protein
  • src1 protein
  • src2 protein
  • src64 protein
  • SRC 64B protein
  • src64b protein
  • xsrc protein
  • zgc:86613 protein

Protein level used designations for NCOA1

nuclear receptor coactivator 1 , DKEY-34F16.7 , SRC1 , steroid receptor RNA activator 1 , Hin-2 protein , PAX3/NCOA1 fusion protein , class E basic helix-loop-helix protein 74 , renal carcinoma antigen NY-REN-52 , steroid receptor coactivator-1 , NCoA-1 , SRC-a/NCoA-1 , mNRC-1 , nuclear receptor coactivator protein 1 , steroid receptor coactivator 1 , SRC-1 , CG7524-PB , CG7524-PC , CG7524-PD , CG7524-PE , CG7524-PF , CG7524-PG , CG7524-PH , CG7524-PI , CG7524-PJ , Src proto oncogene sequence , Src64B-PB , Src64B-PC , Src64B-PD , Src64B-PE , Src64B-PF , Src64B-PG , Src64B-PH , Src64B-PI , Src64B-PJ , mRNA-like ncRNA in embryogenesis 5 , p60-Src-2 , tyrosine protein kinase pp60-c-src , tyrosine-protein kinase Src-2 , v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog

GENE ID SPECIES
422016 Gallus gallus
563288 Danio rerio
459068 Pan troglodytes
100025270 Monodelphis domestica
100385756 Callithrix jacchus
100471908 Ailuropoda melanoleuca
100556605 Anolis carolinensis
415137 Danio rerio
606944 Canis lupus familiaris
780787 Bos taurus
100049723 Xenopus laevis
100135196 Xenopus (Silurana) tropicalis
100173951 Pongo abelii
100345921 Oryctolagus cuniculus
8648 Homo sapiens
17977 Mus musculus
313929 Rattus norvegicus
574068 Sus scrofa
48973 Drosophila melanogaster
380430 Xenopus laevis
475684 Canis lupus familiaris
525346 Bos taurus
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