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The NCOA2 gene encodes nuclear receptor coactivator 2, which aids in the function of nuclear hormone receptors. Additionally we are shipping NCOA2 Proteins (4) and many more products for this protein.
Showing 10 out of 60 products:
Human Polyclonal NCOA2 Primary Antibody for EIA, WB - ABIN493179
Mukherjee, Soyal, Fernandez-Valdivia, Gehin, Chambon, Demayo, Lydon, OMalley: Steroid receptor coactivator 2 is critical for progesterone-dependent uterine function and mammary morphogenesis in the mouse. in Molecular and cellular biology 2006
Show all 5 references for ABIN493179
Dog (Canine) Monoclonal NCOA2 Primary Antibody for IF, WB - ABIN968296
Heery, Kalkhoven, Hoare, Parker: A signature motif in transcriptional co-activators mediates binding to nuclear receptors. in Nature 1997
Show all 4 references for ABIN968296
Chicken Polyclonal NCOA2 Primary Antibody for WB - ABIN2780788
Strehl, Nebral, König, Harbott, Strobl, Ratei, Struski, Bielorai, Lessard, Zimmermann, Haas, Izraeli: ETV6-NCOA2: a novel fusion gene in acute leukemia associated with coexpression of T-lymphoid and myeloid markers and frequent NOTCH1 mutations. in Clinical cancer research : an official journal of the American Association for Cancer Research 2008
Human Polyclonal NCOA2 Primary Antibody for IHC, ELISA - ABIN1450725
Carapeti, Aguiar, Goldman, Cross: A novel fusion between MOZ and the nuclear receptor coactivator TIF2 in acute myeloid leukemia. in Blood 1998
Report NcoA2-regulation of the AhR (show AHR Antibodies)-ARNT (show ARNT Antibodies)-HIF-1a (show HIF1A Antibodies) interaction.
Data suggest that LRH1/NR5A2 (show NR5A2 Antibodies) (liver receptor homologue-1) exhibits phospholipid-mediated allosteric control of protein-protein binding interface in interactions with TIF2 and SHP (show LAMC1 Antibodies) (co-repressor; small heterodimer partner (show NR0B2 Antibodies) protein).
NCOA2 is a novel negative growth regulatory gene repressing the Wnt/beta-catenin pathway in colorectal cancer, where recurrent fusion with LACTB2 contributes to its disruption.
Suggest a possible association between NCOA2 rs10504473 polymorphism and obesity in Chinese Han population.
miR (show MLXIP Antibodies)-137 has a role in targeting p160 (show MSH6 Antibodies) steroid receptor (show ESR2 Antibodies) coactivators SRC1 (show SRC Antibodies), SRC2, and SRC3 (show NCOA3 Antibodies) and inhibits cell proliferation
results suggest that CCNC (show CCNC Antibodies) temporarily protects SRC-2 against degradation and this event is involved in the transcriptional regulation of SRC-2 cell cycle target genes.
Data suggest that over-stimulating the steroid seceptor coactivators SRC-1 (show SRC Antibodies), SRC-2, and SRC-3 (show NCOA3 Antibodies) oncogenic program can be an effective strategy to kill cancer cells.
we provide evidence for involvement of HCK (show HCK Antibodies) and FGR (show FGR Antibodies) in FCRL4 (show FCRL4 Antibodies)-mediated immunoregulation and for the functional importance of posttranslational modifications of the FCRL4 (show FCRL4 Antibodies) molecule.
SRC-2 is a prominent metabolic coordinator of cancer metastasis.
Because deregulation of endometrial SRC-2 expression has been associated with common gynecological disorders of reproductive-age women, this signaling pathway, involving SRC-2 and PFKFB3 (show PFKFB3 Antibodies).
the expression of MOZ (show MYST3 Antibodies)-TIF2 fusion protein represses the transcription of p16INK4a (show CDKN2A Antibodies) and p19ARF (show CDKN2A Antibodies) and blocks senescence.
findings position SRC-2 as a major regulator of polygenic inputs to metabolic gene regulation and perhaps identify a previously unappreciated model that helps to explain the clinical spectrum of glucose dysregulation
fetal lungs produce signals to initiate labor when mature, and SRC-1 (show NCOA1 Antibodies)/-2-dependent production of SP-A (show SFTPA1 Antibodies) and PAF (show KIAA0101 Antibodies) is crucial for this process
In a murine model, overexpression of NCoA2 in the prostate epithelium resulted in neoplasia.
the PAX3 (show PAX3 Antibodies)-NCOA2 fusion gene has a dual role in the tumorigenesis of rhabdomyosarcoma
Transcription factor 23 (Tcf23 (show TCF23 Antibodies)), a basic-helix-loop-helix transcription factor (show HEY1 Antibodies), is a new progesterone-induced target gene that requires SRC-2 for full induction.
SRC-2 is a transcriptional coactivator for BMAL1 (show ARNTL Antibodies):CLOCK. Ablation of SRC-2 disrupts the central clock.
SRC-2 is critical to transcriptional control modulated by MEF2 (show MEF2C Antibodies), GATA-4 (show GATA4 Antibodies), and Tbx5 (show TBX5 Antibodies), thereby enhancing gene expression associated with cardiac growth.
SRC2 regulates anxiety response with SRC2(-/-) females showing decreased anxiety in novel environments.
Our results indicate that SRC-2 is involved in maintenance of the steady-state adult heart transcriptional profile, with its ablation inducing transcriptional changes that mimic a stressed heart.
The tif2 is involved in embryogenesis and in primitive hematopoiesis. tif2-knockdown zebrafish embryos are smaller than controls.
The NCOA2 gene encodes nuclear receptor coactivator 2, which aids in the function of nuclear hormone receptors. Nuclear hormone receptors are conditional transcription factors that play important roles in various aspects of cell growth, development, and homeostasis by controlling expression of specific genes. Members of the nuclear hormone receptor superfamily, which includes the 5 steroid receptors and class II nuclear receptors (see below), are structurally characterized by 3 distinct domains: an N-terminal transcriptional activation domain, a central DNA-binding domain, and a C-terminal hormone-binding domain. Before the binding of hormone, steroid receptors, which are sometimes called class I of the nuclear hormone receptor family, remain inactive in a complex with heat-shock protein-90 (MIM 140571) and other stress family proteins. Binding of hormone induces critical conformational changes in steroid receptors that cause them to dissociate from the inhibitory complex, bind as homodimers to specific DNA enhancer elements associated with target genes, and modulate that gene's transcription. After binding to enhancer elements, transcription factors require transcriptional coactivator proteins to mediate their stimulation of transcription initiation (Hong et al., 1997
nuclear receptor coactivator 2
, Transcriptional intermediary factor 2
, nuclear receptor coactivator 2-like
, Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog
, c-fgr protooncogene
, c-src-2 proto-oncogene
, p55-c-fgr protein
, proto-oncogene c-Fgr
, proto-oncogene tyrosine-protein kinase FGR
, tyrosine-protein kinase Fgr
, v-fgr feline Gardner-Rasheed sarcoma viral oncogene homolog
, class E basic helix-loop-helix protein 75
, glucocorticoid receptor-interacting protein-1
, transcriptional intermediary factor 2
, glucocorticoid receptor interacting protein 1
, glucocorticoid receptor-interacting protein 1
, transcriptional intermediary factor-2
, steroid receptor coactivator 2