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Nuclear Receptor Coactivator 3 Proteins (NCOA3)

The protein encoded by NCOA3 is a nuclear receptor coactivator that interacts with nuclear hormone receptors to enhance their transcriptional activator functions. Additionally we are shipping Nuclear Receptor Coactivator 3 Antibodies (152) and Nuclear Receptor Coactivator 3 Kits (9) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
NCOA3 8202 Q9Y6Q9
NCOA3 17979  
Rat NCOA3 NCOA3 84584  
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Top Nuclear Receptor Coactivator 3 Proteins at antibodies-online.com

Showing 3 out of 3 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 to 54 Days
$13,567.94
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 to 54 Days
$13,567.94
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details

NCOA3 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

More Proteins for Nuclear Receptor Coactivator 3 (NCOA3) Interaction Partners

Human Nuclear Receptor Coactivator 3 (NCOA3) interaction partners

  1. Total SRC3 is selectively found at enhancer regions.

  2. The transcriptional coactivator SRC-3.

  3. The aim of this study was to investigate the expression of AIB1 in human esophageal squamous cell carcinoma and its correlation with Ki67 (show MKI67 Proteins) expression.

  4. NCOA3 polymorphisms might influence the risk of dyslipidemia and serum lipid levels in Chinese Han population.

  5. miR (show MLXIP Proteins)-137 has a role in targeting p160 (show MSH6 Proteins) steroid receptor (show ESR2 Proteins) coactivators SRC1 (show SRC Proteins), SRC2 (show NCOA2 Proteins), and SRC3 and inhibits cell proliferation

  6. AIB1 promotes gastric cancer cell proliferation, survival and invasiveness through modulating major signaling pathways such as ErbB (show EGFR Proteins) and Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) pathways. Findings suggest that AIB1 plays an important role in the pathogenesis of gastric cancer.

  7. ER-alpha (show ESR1 Proteins), SRC-3, and p300 (show EP300 Proteins) form an active protein complex on estrogen response element-DNA.

  8. NCOA3 is subject to a cis (show CISH Proteins)-acting expression quantitative trait locus in articular cartilage, which correlates with the osteoarthritis association signal and with the OA-associated allele of the SNP rs116855380, which is located 10.3 kb upstream of NCOA3.

  9. we describe a TR-FRET assay that monitors the interaction of the estrogen receptor (ER) alpha (show ESR1 Proteins) ligand binding domain (labeled with a terbium chelate via a streptavidin-biotin interaction) with a sequence of coactivator protein SRC3

  10. NCOA3 upregulates mucin 1 (show MUC1 Proteins) and 4 via transcriptional and post-translational changes in pancreatic cancer.

Mouse (Murine) Nuclear Receptor Coactivator 3 (NCOA3) interaction partners

  1. SRC-1 (show NCOA1 Proteins)/3 are required for cardiomyocyte proliferation and differentiation at earlier developmental stages, and their dysfunction causes NCC (show SLC12A3 Proteins)-like abnormalities in the hearts of newborn and adult mice.

  2. AIB1 promotes gastric cancer cell proliferation, survival and invasiveness through modulating major signaling pathways such as ErbB (show EGFR Proteins) and Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) pathways. Findings suggest that AIB1 plays an important role in the pathogenesis of gastric cancer.

  3. SRC-3 is a target for inhibiting aggressive prostate cancer containing neuroendocrine tumor cells.

  4. Impaired hematopoiesis and delayed thrombopoietic recovery following sublethal irradiation in SRC3 knockout mice.

  5. The p/CIP gene regulatory network identifies various feed-forward modules including one in which p/CIP activates members of the extended pluripotency network, demonstrating that p/CIP is a component of this extended network.

  6. Loss of SRC3 also shows sex differences in anxiety and exploratory behaviors.

  7. IRS1 (show IRS1 Proteins) levels are significantly increased in mouse cell lines representing fat and muscle lineages with p/CIP and SRC-1 (show NCOA1 Proteins) deletions and in white adipose tissue and skeletal muscle of knockout mice.

  8. Data show that knockdown of nuclear receptor coactivator 3 (Ncoa3) not only compromises the expression of pluripotency markers but also impairs in vitro and in vivo differentiation potential of embryonic stem cells.

  9. Ncoa3, an essential coactivator, is required to mediate Esrrb function in embryonic stem cells.

  10. A previously unknown function of SRC-3 in the control of endothelial cell phenotypes in vitro and neogenesis and physiologic wound healing in vivo is shown.

Nuclear Receptor Coactivator 3 (NCOA3) Protein Profile

Protein Summary

The protein encoded by this gene is a nuclear receptor coactivator that interacts with nuclear hormone receptors to enhance their transcriptional activator functions. The encoded protein has histone acetyltransferase activity and recruits p300/CBP-associated factor and CREB binding protein as part of a multisubunit coactivation complex. This protein is initially found in the cytoplasm but is translocated into the nucleus upon phosphorylation. Several transcript variants encoding different isoforms have been found for this gene. In addition, a polymorphic repeat region is found in the C-terminus of the encoded protein.

Gene names and symbols associated with NCOA3

  • nuclear receptor coactivator 3 (NCOA3)
  • nuclear receptor coactivator 3 (Ncoa3)
  • nuclear receptor coactivator 3 (ncoa3)
  • 2010305B15Rik protein
  • actr protein
  • aib-1 protein
  • aib1 protein
  • AW321064 protein
  • bHLHe42 protein
  • cagh16 protein
  • ctg26 protein
  • kat13b protein
  • NCOA3 protein
  • p/Cip protein
  • pcip protein
  • rac3 protein
  • src-3 protein
  • src3 protein
  • tnrc14 protein
  • tnrc16 protein
  • tram-1 protein
  • Tram1 protein
  • xSRC-3 protein

Protein level used designations for NCOA3

nuclear receptor coactivator 3 , CBP-interacting protein , amplified in breast cancer 1 protein , class E basic helix-loop-helix protein 42 , receptor-associated coactivator 3 , steroid receptor coactivator protein 3 , thyroid hormone receptor activator molecule 1 , steroid receptor coactivator 3 , AIB-1 , NCoA-3 , RAC-3 , SRC-3 , amplified in breast cancer-1 protein homolog , retinoid X receptor-interacting coactivator xSRC-3

GENE ID SPECIES
705431 Macaca mulatta
8202 Homo sapiens
100135659 Sus scrofa
17979 Mus musculus
485915 Canis lupus familiaris
523707 Bos taurus
84584 Rattus norvegicus
398021 Xenopus laevis
419208 Gallus gallus
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