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Nuclear Receptor Coactivator 4 Proteins (NCOA4)

NCOA4 encodes an androgen receptor coactivator. Additionally we are shipping NCOA4 Antibodies (83) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Rat NCOA4 NCOA4 619385  
NCOA4 8031 Q13772
Mouse NCOA4 NCOA4 27057  
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Top NCOA4 Proteins at antibodies-online.com

Showing 4 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Baculovirus infected Insect Cells Human GST tag   5 μg Log in to see 10 to 12 Days
$365.64
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

NCOA4 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
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More Proteins for Nuclear Receptor Coactivator 4 (NCOA4) Interaction Partners

Xenopus laevis Nuclear Receptor Coactivator 4 (NCOA4) interaction partners

  1. NCOA4 acts as a regulator of DNA replication origins that helps prevent inappropriate DNA synthesis and replication stress.

Human Nuclear Receptor Coactivator 4 (NCOA4) interaction partners

  1. Ubiquitin-dependent NCOA4 turnover is promoted by excess iron and involves an iron-dependent interaction between NCOA4 and the HERC2 ubiquitin ligase.

  2. Studies indicate nuclear receptor coactivator 4 (NcoA4) as a coactivator for a variety of nuclear receptors.

  3. provide a new mechanism for selective autophagy of ferritin (show FTL Proteins) and reveal a previously unappreciated role for autophagy and NCOA4 in the control of iron homeostasis in vivo

  4. RET (show RET Proteins)/PTC3 gene rearrangements are the most prevalent form of rearrangements in papillary thyroid carcinomas of Chennai population.

  5. NCOA4 acts as a regulator of DNA replication origins that helps prevent inappropriate DNA synthesis and replication stress.

  6. identification of NCOA4 as a selective cargo receptor for autophagic turnover of ferritin (show FTL Proteins) (ferritinophagy), which is critical for iron homeostasis, and provides a resource for further dissection of autophagosomal cargo-receptor connectivity

  7. mechanism dissection shows that KLK2 (show KLK2 Proteins) may cooperate with the AR coregulator, ARA70, to enhance AR transactivation that may result in alteration of prostate cancer formation

  8. Data indicate that the increase in prostate cancer (PC) risk associated with rs10993994:C>T is likely mediated by the variant's effect of MSMB (show MSMB Proteins)-encoded protein PSP94 (show MSMB Proteins) expression; however, this effect does not extend to NCOA4 in the data.

  9. Computational network analysis reveals that the MSMB (show MSMB Proteins) gene is functionally connected to NCOA4 and the androgen receptor (show AR Proteins) signaling pathway. The data provide an example of how GWAS-associated variants may have multiple genetic and epigenetic effects

  10. Suppression of MSMB (show MSMB Proteins) expression or NCOA4 overexpression promotes anchorage-independent growth of prostate epithelial cells.

Mouse (Murine) Nuclear Receptor Coactivator 4 (NCOA4) interaction partners

  1. NCOA4 prevents iron accumulation and ensures efficient erythropoiesis, playing a central role in balancing iron levels in vivo.

  2. provide a new mechanism for selective autophagy of ferritin (show FTL Proteins) and reveal a previously unappreciated role for autophagy and NCOA4 in the control of iron homeostasis in vivo

  3. NCOA4 acts as a regulator of DNA replication origins that helps prevent inappropriate DNA synthesis and replication stress.

  4. Results demonstrate ubiquitous NcoA4 expression throughout development and suggest that this coactivator may play a role in modulating nuclear receptor activity, particularly that of the aryl hydrocarbon receptor (show AHR Proteins), during development.

  5. Data suggest that myostatin (show MSTN Proteins) decreases the activity of androgen receptors (AR) by down-regulating the expression of ARA70, a known stimulating co-factor of AR

NCOA4 Protein Profile

Protein Summary

This gene encodes an androgen receptor coactivator. The encoded protein interacts with the androgen receptor in a ligand-dependent manner to enhance its transcriptional activity. Chromosomal translocations between this gene and the ret tyrosine kinase gene, also located on chromosome 10, have been associated with papillary thyroid carcinoma. Alternatively spliced transcript variants have been described. Pseudogenes are present on chromosomes 4, 5, 10, and 14.

Gene names and symbols associated with NCOA4

  • nuclear receptor coactivator 4 (Ncoa4)
  • nuclear receptor coactivator 4 (ncoa4)
  • nuclear receptor coactivator 4 (NCOA4)
  • Nuclear receptor coactivator 4 (ncoa4)
  • 1110034E15Rik protein
  • 4432406M01Rik protein
  • AI227008 protein
  • ARA70 protein
  • DKFZp459B2429 protein
  • DKFZp469A035 protein
  • DKFZp469A1925 protein
  • ELE1 protein
  • MGC84996 protein
  • MGC138109 protein
  • ncoa4 protein
  • PTC3 protein
  • Rfg protein
  • zgc:55307 protein
  • zgc:77270 protein

Protein level used designations for NCOA4

nuclear receptor coactivator 4 , Nuclear receptor coactivator 4 , 70 kDa AR-activator , 70 kDa androgen receptor coactivator , NCoA-4 , RET-activating gene ELE1 , androgen receptor-associated protein of 70 kDa , ret fused

GENE ID SPECIES
619385 Rattus norvegicus
394104 Danio rerio
423615 Gallus gallus
450455 Pan troglodytes
525329 Bos taurus
734285 Xenopus laevis
100156184 Sus scrofa
100172727 Pongo abelii
100306816 Salmo salar
8031 Homo sapiens
27057 Mus musculus
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