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Nuclear Receptor Coactivator 6 Proteins (NCOA6)

The protein encoded by NCOA6 is a transcriptional coactivator that can interact with nuclear hormone receptors to enhance their transcriptional activator functions. Additionally we are shipping NCOA6 Antibodies (11) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
NCOA6 23054 Q14686
Mouse NCOA6 NCOA6 56406  
NCOA6 116464  
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Top NCOA6 Proteins at antibodies-online.com

Showing 2 out of 2 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$3,162.50
Details

NCOA6 Proteins by Origin and Source

Origin Expressed in Conjugate
Human

Rat (Rattus)

More Proteins for Nuclear Receptor Coactivator 6 (NCOA6) Interaction Partners

Human Nuclear Receptor Coactivator 6 (NCOA6) interaction partners

  1. The retinoid x receptor (show RXRB Proteins) does not interact with the NR box-1 of ASC-2, but functions as an allosteric activator of LXR (show NR1H3 Proteins) binding to NR box-2 of ASC-2.

  2. diverse physiological function of NCOA6 may be mediated by multiple isoforms expressed in different tissues and localized in different subcellular compartments

  3. NCOA6 is responsible for the synergistic activation of CYP2C9 (show CYP2C9 Proteins) by HNF4alpha (show HNF4A Proteins) and pregnane X receptor (show NR1I2 Proteins) and NCOA6 differentially regulates CYP2C9 (show CYP2C9 Proteins) and CYP3A4 (show CYP3A4 Proteins) gene expression though both the genes are regulated by the same nuclear receptors.

  4. we show that ASC-2 belongs to a steady-state complex of approximately 2 MDa (ASC-2 complex [ASCOM]) in HeLa nuclei. ASCOM contains retinoblastoma-binding protein RBQ-3 (show RBBP5 Proteins), alpha/beta-tubulins, and trithorax (show MLLT1 Proteins) group proteins ALR-1, ALR-2 (show AKR1B1 Proteins), HALR, and ASH2 (show ASCL2 Proteins).

  5. The activation of DNA-PK in the absence of DNA ends by the coactivator TRBP suggests a novel mechanism of coactivator-stimulated DNA-PK phosphorylation in transcriptional regulation.

  6. ASC-2 is a physiologically important transcriptional coactivator of LXRs and demonstrate its pivotal role in the liver lipid metabolism

  7. ASC-2 appears to contain at least three distinct nuclear receptor interaction domains; also, Rb and ASC-2 have roles in androgen receptor (show AR Proteins) transactivation

  8. ASC-2 has a role in inducing target gene transcription during granulocytic differentiation through binding to ATF2 (show ATF2 Proteins)

  9. results suggest that ASC-2 is a novel coactivator for HSF1 (show HSF1 Proteins) and heat shock stress may contribute to the strong active transcription complex through sequential recruitment of HSF1 (show HSF1 Proteins) and ASC-2.

  10. ASC-2 is a bona fide coactivator of the xenobiotic nuclear receptor CAR and mediate the specific xenobiotic response by CAR in vivo.

Mouse (Murine) Nuclear Receptor Coactivator 6 (NCOA6) interaction partners

  1. These results indicate that PRIP is implicated in BMP-induced osteoblast differentiation by the negative regulation of Smad (show SMAD1 Proteins) phosphorylation, through the methylation of inhibitory Smad6 (show SMAD6 Proteins).

  2. The results indicate that PRIP negatively regulates UCP1 (show UCP1 Proteins)-mediated thermogenesis in brown adipocytes.

  3. Two independent mouse models of NCOA6 dysfunction develop severe dilated cardiomyopathy with impaired mitochondrial function and reduced activity of peroxisome proliferator-activated receptor delta (show PPARD Proteins).

  4. The NCOA6 controls E(2) sensitivity and uterine receptivity by regulating multiple E(2)-signaling components.

  5. ASC-2 negatively affects hepatic insulin (show INS Proteins) sensitivity, at least in part, through induction of the insulin (show INS Proteins) signalling inhibitors SOCS1 (show SOCS1 Proteins) and SOCS3 (show SOCS3 Proteins).

  6. PRIP is implicated in the negative regulation of bone formation

  7. diverse physiological function of NCOA6 may be mediated by multiple isoforms expressed in different tissues and localized in different subcellular compartments

  8. methylation of transporter promoters by MLL3 as part of activating signal cointegrator-2 -containing complex is essential for activation of bile salt export pump (show ABCB11 Proteins)

  9. The apoptotic-like processes in the transgenic lens were both p53 (show TP53 Proteins)-dependent and p53 (show TP53 Proteins)-independent. Lens-specific deletion of Ncoa6 also resulted in disrupted lens fiber cell differentiation.

  10. These results suggest that AIB3 is required for PPARgamma (show PPARG Proteins) function in placental development and for normal heart development.

NCOA6 Protein Profile

Protein Summary

The protein encoded by this gene is a transcriptional coactivator that can interact with nuclear hormone receptors to enhance their transcriptional activator functions. This protein has been shown to be involved in the hormone-dependent coactivation of several receptors, including prostanoid, retinoid, vitamin D3, thyroid hormone, and steroid receptors. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Gene names and symbols associated with NCOA6

  • nuclear receptor coactivator 6 (NCOA6)
  • nuclear receptor coactivator 6 (Tsp_14219)
  • nuclear receptor coactivator 6 (Tsp_13372)
  • nuclear receptor coactivator 6 (ncoa6)
  • Nuclear receptor coactivator 6 (ncoa6)
  • nuclear receptor coactivator 6 (Ncoa6)
  • Aib3 protein
  • ASC-2 protein
  • ASC2 protein
  • gb:dq017635 protein
  • mKIAA0181 protein
  • ncoa6 protein
  • Ncoa7 protein
  • NRC protein
  • PRIP protein
  • RAP250 protein
  • Trbp protein
  • wu:fb25d11 protein

Protein level used designations for NCOA6

nuclear receptor coactivator 6 , Nuclear receptor coactivator 6 , NRC RAP250 , PPAR-interacting protein , activating signal cointegrator 2 , activating signal cointegrator-2 , amplified in breast cancer protein 3 , amplified in breast cancer-3 protein , cancer-amplified transcriptional coactivator ASC-2 , nuclear receptor coactivator RAP250 , nuclear receptor-activating protein, 250 kDa , peroxisome proliferator-activated receptor interacting protein , peroxisome proliferator-activated receptor-interacting protein , thyroid hormone receptor binding protein , thyroid hormone receptor-binding protein , PPAR interacting protein PRIP , nuclear receptor-activating protein 250 , peroxisome proliferator-activated receptor interacting protein,PRIP

GENE ID SPECIES
419122 Gallus gallus
10908202 Trichinella spiralis
10910561 Trichinella spiralis
100144559 Danio rerio
100196047 Salmo salar
23054 Homo sapiens
56406 Mus musculus
116464 Rattus norvegicus
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