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Nuclear Transcription Factor Y, alpha Proteins (NFYA)

The protein encoded by NFYA is one subunit of a trimeric complex, forming a highly conserved transcription factor that binds to CCAAT motifs in the promoter regions in a variety of genes. Additionally we are shipping NFYA Antibodies (42) and NFYA Kits (2) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
NFYA 4800 P23511
NFYA 18044 P23708
NFYA 29508 P18576
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Top NFYA Proteins at antibodies-online.com

Showing 6 out of 9 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Human GST tag   50 μg Log in to see 5 Days
$522.50
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$2,924.17
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$2,924.17
Details

NFYA Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

Rat (Rattus)

More Proteins for Nuclear Transcription Factor Y, alpha (NFYA) Interaction Partners

Human Nuclear Transcription Factor Y, alpha (NFYA) interaction partners

  1. our results indicate that NF-YA alternative splicing is an influential muscle cell determinant, through direct regulation of selected cell cycle blocking genes, and, directly and indirectly, of muscle-specific (show EIF3K Proteins) transcription factors

  2. enhanced CDCA8 (show CDCA8 Proteins) promoter activities by NF-Y overexpression and reduced CDCA8 (show CDCA8 Proteins) transcription by NF-Y knockdown further verified that NF-Y is a positive regulator of CDCA8 (show CDCA8 Proteins) transcription.

  3. Data show that Zinc-fingers and homeoboxes 2 (ZHX2 (show ZHX2 Proteins)) represses nuclear transcription factor Y alpha (NF-Y)-mediated activation of multidrug resistance 1 (MDR1) transcription.

  4. NF-Y inhibits NT2/D1 cell growth in p53 (show TP53 Proteins)-independent manner and decreases SOX2 (show SOX2 Proteins) expression.

  5. Stimulation of the lymphocytes with phytohemagglutinin, restores normal OGG1 (show OGG1 Proteins) levels and repair rates. MAP kinase (show MAPK1 Proteins) c-Jun N-terminal kinase (JNK) and the recruitment of the transcription factor NFYA to the promoter region of OGG1 (show OGG1 Proteins) are shown to be involved.

  6. Association of p21 with NF-YA suppresses the expression of PLK1 and prevents mitotic death in response to DNA damage.

  7. NF-YA binds directly over the CCAAT sequence.

  8. NF-Y recruits the developmentally regulated, erythroid transcription activator GATA-2 and general repressor BCL11A to modulate transcription of the gamma-globin gene.

  9. The crystal structure of NF-Y bound to a 25 bp CCAAT oligonucleotide shows that the histone-fold domains dimer binds to the DNA sugar-phosphate backbone, mimicking the nucleosome H2A/H2B-DNA assembly; NF-YA both binds to NF-YB (show NFYB Proteins)/NF-YC (show NFYC Proteins) and inserts an alpha helix deeply into the DNA minor groove, providing sequence-specific contacts to the CCAAT box.

  10. NFYA could be a target of mutant TBP (show TBP Proteins) in SCA17 (show TBP Proteins).

Cow (Bovine) Nuclear Transcription Factor Y, alpha (NFYA) interaction partners

  1. Interaction of C/EBP-beta and NF-Y factors constrains activity levels of the nutritionally controlled promoter IA expressing the acetyl-CoA carboxylase-alpha gene in cattle.

Mouse (Murine) Nuclear Transcription Factor Y, alpha (NFYA) interaction partners

  1. we conclude that NF-Y and YY1 (show YY1 Proteins) are important for the basal transcription of Pcyt2 (show PCYT2 Proteins) and that NF-Y is involved in the inhibitory effects of 25-HC on Pcyt2 (show PCYT2 Proteins) transcription.

  2. these results indicate that the transcription factor NF-Y regulates the proximal promoter activity of mouse Col11a1 gene in chondrocytes

  3. these results raise an exciting possibility that targeting CDK1 (show CDK1 Proteins) or NF-Y in the diseased heart may inhibit fibrosis and subsequently confer cardioprotection.

  4. NF-Ya is a functional activator of Bmal1 (show ARNTL Proteins) transcription and it cooperates with Sp1 (show SP1 Proteins) and Rev-Erbalpha (show NR1D1 Proteins) to generate the daily cycle of Bmal1 (show ARNTL Proteins) expression.

  5. Sp1 (show SP1 Proteins), CREB (show CREB1 Proteins), HNF-1 (show HNF1A Proteins), and NF-Y, known to be responsive to hormones and diet, regulate NAGS (show NAGS Proteins) transcription

  6. results indicate nuclear transcription factor NF-Y as a pivotal upstream participant in a regulatory network necessary for the preservation of cycling hematopoietic stem cell.

  7. Findings establish that NF-Y acts upstream of E2F1 (show E2F1 Proteins) in p53 (show TP53 Proteins)-mediated apoptosis.

  8. Transcriptional regulation of myeloid differentiation primary response (MyD) genes during myeloid differentiation is mediated by nuclear factor Y.

  9. NF-Y recruits RNAPII and general transcription factors onto various CCAAT box-containing promoters to permit strong transcriptional activation independently of histone modifications

  10. NF-Y can stimulate or repress the FGF-4 (show FGF4 Proteins) promoter in an enhancer-dependent manner

NFYA Protein Profile

Protein Summary

The protein encoded by this gene is one subunit of a trimeric complex, forming a highly conserved transcription factor that binds to CCAAT motifs in the promoter regions in a variety of genes. Subunit A associates with a tight dimer composed of the B and C subunits, resulting in a trimer that binds to DNA with high specificity and affinity. The sequence specific interactions of the complex are made by the A subunit, suggesting a role as the regulatory subunit. In addition, there is evidence of post-transcriptional regulation in this gene product, either by protein degradation or control of translation. Further regulation is represented by alternative splicing in the glutamine-rich activation domain, with clear tissue-specific preferences for the two isoforms.

Gene names and symbols associated with NFYA

  • nuclear transcription factor Y, alpha (nfya)
  • nuclear transcription factor Y, alpha (NFYA)
  • nuclear transcription factor-Y alpha (Nfya)
  • AA407810 protein
  • CBF-A protein
  • Cbf-b protein
  • HAP2 protein
  • ik:tdsubc_2b6 protein
  • NF-YA protein
  • NFYA protein
  • SEZ-10 protein
  • SEZ10 protein
  • wu:fb16e03 protein
  • xx:tdsubc_2b6 protein

Protein level used designations for NFYA

fb16e03 , tdsubc_2b6 , nuclear transcription factor Y, alpha , CAAT box DNA-binding protein subunit A , CAAT-box DNA binding protein subunit A , CCAAT-binding transcription factor subunit B , HAP2 CCAAT-binding protein , Transcription factor NF-Y, A subunit , nuclear transcription factor Y subunit A , nuclear transcription factor Y subunit alpha , CAAT-box DNA-binding protein subunit A , NF-Y protein chain A , nuclear transcription factor-Y alpha , NF-YA , CBF-B

GENE ID SPECIES
83915 Danio rerio
748395 Pan troglodytes
4800 Homo sapiens
419917 Gallus gallus
474897 Canis lupus familiaris
539584 Bos taurus
18044 Mus musculus
29508 Rattus norvegicus
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