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Nuclear Transcription Factor Y, beta Proteins (NFYB)

The protein encoded by NFYB is one subunit of a trimeric complex, forming a highly conserved transcription factor that binds with high specificity to CCAAT motifs in the promoter regions in a variety of genes. Additionally we are shipping NFYB Antibodies (68) and NFYB Kits (2) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
NFYB 4801 P25208
NFYB 18045 P63139
NFYB 25336 P63140
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Top NFYB Proteins at antibodies-online.com

Showing 9 out of 9 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Xenopus laevis His tag   1 mg Log in to see 56 to 66 Days
$2,244.00
Details
Yeast Chicken His tag   1 mg Log in to see 56 to 66 Days
$2,500.67
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$2,508.00
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$2,508.00
Details
Yeast Petromyzon marinus His tag   1 mg Log in to see 56 to 66 Days
$2,513.50
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

NFYB Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

Rat (Rattus)

More Proteins for Nuclear Transcription Factor Y, beta (NFYB) Interaction Partners

Human Nuclear Transcription Factor Y, beta (NFYB) interaction partners

  1. NF-YB transcription factor was identified as a novel direct E2F1 (show E2F1 Proteins) target.

  2. The NF-Y complex is asymmetric, with NF-YB binding approximately 15 bp downstream from the CCAAT motif.

  3. The crystal structure of NF-Y bound to a 25 bp CCAAT oligonucleotide shows that the histone-fold domains dimer binds to the DNA sugar-phosphate backbone, mimicking the nucleosome H2A/H2B-DNA assembly; NF-YA (show NFYA Proteins) both binds to NF-YB/NF-YC (show NFYC Proteins) and inserts an alpha helix deeply into the DNA minor groove, providing sequence-specific contacts to the CCAAT box.

  4. Transcriptional repression mediated by IER5 (show IER5 Proteins) regulates Cdc25B (show CDC25B Proteins) expression levels via the release of NF-YB and p300 (show EP300 Proteins) in acute myeloid leukemia (show BCL11A Proteins).

  5. NF-Y acts upstream of H3K4me3 deposition by recruiting Ash2L (show ASH2L Proteins)

  6. The NF-YB/NF-YC (show NFYC Proteins) structure gives insight into DNA binding and transcription regulation by CCAAT factor NF-Y.

  7. p300 (show EP300 Proteins) binds to multiple NF-Y trimers to regulate cyclin B2 (show CCNB2 Proteins) promoter function

  8. CBF/NF-Y proteins regulate the transcription of COL11A1 by directly binding to the ATTGG sequence in the proximal promoter region

  9. Histone deacetylase (show HDAC1 Proteins) inhibitors can induce Gadd45 (show GADD45A Proteins) through its promoter without the need for functional p53 (show TP53 Proteins), and both Oct-1 (show POU2F1 Proteins) and NF-Y concertedly participate in trichostatin A-induced activation of the gadd45 (show GADD45A Proteins) promoter.

  10. p53 (show TP53 Proteins) negatively regulates Chk2 (show CHEK2 Proteins) gene transcription through modulation of NF-Y function and that this regulation may be important for reentry of cells into the cell cycle after DNA damage is repaired.

Pig (Porcine) Nuclear Transcription Factor Y, beta (NFYB) interaction partners

  1. results exclude NFYB as candidate gene for congenital splay leg but provide a basis for selection of further candidates for the disease from SSC5

Mouse (Murine) Nuclear Transcription Factor Y, beta (NFYB) interaction partners

  1. deletion of CBF-B (show NFYA Proteins) activated expression of specific endoplasmic reticulum stress-regulated genes. Inactivation of CBF-B (show NFYA Proteins) also inhibited expression of C/EBP alpha (show CEBPA Proteins), an important transcription factor controlling metabolic processes in adult hepatocytes

  2. p73 (show ARHGAP24 Proteins) and DeltaNp73 behave as physiological regulators for recruitment of histone deacetylase (show HDAC1 Proteins) to NF-Y and transcription of the PDGFRB (show PDGFRB Proteins) promoter

  3. CBF-A (show CEBPA Proteins) is a novel transacting factor required for cytoplasmic mRNA transport and localization

NFYB Protein Profile

Protein Summary

The protein encoded by this gene is one subunit of a trimeric complex, forming a highly conserved transcription factor that binds with high specificity to CCAAT motifs in the promoter regions in a variety of genes. This gene product, subunit B, forms a tight dimer with the C subunit, a prerequisite for subunit A association. The resulting trimer binds to DNA with high specificity and affinity. Subunits B and C each contain a histone-like motif. Observation of the histone nature of these subunits is supported by two types of evidence\; protein sequence alignments and experiments with mutants.

Gene names and symbols associated with NFYB

  • nuclear transcription factor Y, beta (NFYB)
  • nuclear transcription factor Y, beta (nfyb)
  • nuclear transcription factor Y, beta b (nfybb)
  • nuclear transcription factor-Y beta (Nfyb)
  • AA985999 protein
  • Cbf-A protein
  • CBF-B protein
  • CBFB protein
  • HAP3 protein
  • NF-YB protein
  • Nfya protein
  • nfyb protein
  • zgc:110533 protein

Protein level used designations for NFYB

nuclear transcription factor Y, beta , nuclear transcription factor Y subunit beta , CAAT box DNA-binding protein subunit B , CCAAT-binding transcription factor subunit A , Transcription factor NF-Y, B subunit , nuclear transcription factor Y subunit B , nuclear Y/CCAAT-box binding factor B subunit NF-YB , CAAT-box DNA binding protein subunit B (NF-YB) , CAAT-box DNA-binding protein subunit B , NF-YB , nuclear transcription factor Y beta , CBF-A , CCAAT binding transcription factor of CBF-B/NFY-B , nuclear transcription factor - Y beta

GENE ID SPECIES
452191 Pan troglodytes
700451 Macaca mulatta
100135753 Xenopus (Silurana) tropicalis
4801 Homo sapiens
399126 Xenopus laevis
396205 Gallus gallus
475450 Canis lupus familiaris
614382 Bos taurus
100157587 Sus scrofa
100034044 Equus caballus
503744 Danio rerio
18045 Mus musculus
25336 Rattus norvegicus
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