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Nucleophosmin (Nucleolar phosphoprotein B23, Numatrin) Proteins (NPM1)

NPM1 encodes a phosphoprotein which moves between the nucleus and the cytoplasm. Additionally we are shipping Nucleophosmin (Nucleolar phosphoprotein B23, Numatrin) Antibodies (309) and Nucleophosmin (Nucleolar phosphoprotein B23, Numatrin) Kits (13) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
NPM1 4869 P06748
NPM1 25498 P13084
NPM1 18148 Q61937
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Top Nucleophosmin (Nucleolar phosphoprotein B23, Numatrin) Proteins at antibodies-online.com

Showing 10 out of 24 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 7 to 8 Days
$319.00
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 16 Days
$382.80
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 11 to 13 Days
$721.60
Details
HOST_Escherichia coli (E. coli) Mouse His tag 100 μg Log in to see 11 to 13 Days
$774.40
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$2,772.00
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$2,777.50
Details
Yeast Chicken His tag   1 mg Log in to see 56 to 66 Days
$2,777.50
Details

NPM1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Rat (Rattus)

Mouse (Murine)

Top referenced Nucleophosmin (Nucleolar phosphoprotein B23, Numatrin) Proteins

  1. Human NPM1 Protein expressed in Escherichia coli (E. coli) - ABIN1098300 : Ovcharenko, Stölzel, Poitz, Fierro, Schaich, Neubauer, Kelnar, Davison, Müller-Tidow, Thiede, Bornhäuser, Ehninger, Brown, Illmer: miR-10a overexpression is associated with NPM1 mutations and MDM4 downregulation in intermediate-risk acute myeloid leukemia. in Experimental hematology 2011 (PubMed)
    Show all 2 references for ABIN1098300

  2. Human NPM1 Protein expressed in Wheat germ - ABIN1312882 : Xu, Fang, Dhar, St Clair, Kasarskis, St Clair: The role of a single-stranded nucleotide loop in transcriptional regulation of the human sod2 gene. in The Journal of biological chemistry 2007 (PubMed)
    Show all 2 references for ABIN1312882

  3. Human NPM1 Protein expressed in Escherichia coli (E. coli) - ABIN2001975 : Chan, Chan, Morris, Xie: Isolation and characterization of the human nucleophosmin/B23 (NPM) gene: identification of the YY1 binding site at the 5' enhancer region. in Nucleic acids research 1997 (PubMed)
    Show all 2 references for ABIN2001975

More Proteins for Nucleophosmin (Nucleolar phosphoprotein B23, Numatrin) (NPM1) Interaction Partners

Human Nucleophosmin (Nucleolar phosphoprotein B23, Numatrin) (NPM1) interaction partners

  1. CMML with NPM1 mutation shows histopathological features of CMML, but patients appear to have a high probability for AML (show RUNX1 Proteins) progression and may require aggressive clinical intervention, especially in patients with a high mutation burden.

  2. demonstrated that p-NPM-Thr234/237 is critical in invasion and migration of hepatocellular carcinoma cells

  3. NPM-RAR (show RARA Proteins) binding to TRADD (show TRADD Proteins) selectively inhibits caspase (show CASP3 Proteins) activation, while allowing activation of NFkappaB (show NFKB1 Proteins) and JNK (show MAPK8 Proteins)

  4. The results indicated significant differences in the integral optical density and less so in the areas of NPM+ nucleoli in leiomyosarcomas, but not in intact myometrium and leiomyomas.

  5. NPM1 histone chaperone is upregulated in glioblastoma to promote cell survival and maintain nucleolar shape

  6. This finding implicates a new role of NPM1 in conveying tumorigenic signals from the BCR-ABL (show ABL1 Proteins) oncoprotein to ribosome biogenesis, affecting cellular growth.

  7. The NPM1 gene did not reveal any copy number alterations in acute myeloid leukemia (show BCL11A Proteins).

  8. Overexpression of the cytoplasmic mutant of nucleophosmin (NPM) causes increased phosphorylation of NPM on T199.

  9. Results show FLT3 (show FLT3 Proteins), NPM1, and CEBPA (show CEBPA Proteins) combination genotype confer favourable prognosis in AML (show RUNX1 Proteins)

  10. Designed a real-time PCR method using 3'-modified oligonucleotides technique to detect NPM1 mutations; validated its utility in clinical samples.

Cow (Bovine) Nucleophosmin (Nucleolar phosphoprotein B23, Numatrin) (NPM1) interaction partners

  1. Results suggest that some polymorphisms in NPM1 are associated with body weight at some ages and may be used as candidates for marker-assisted selection and management in beef cattle breeding programmes.

  2. The NPM1 gene is a candidate gene for growth traits in cattle.

Mouse (Murine) Nucleophosmin (Nucleolar phosphoprotein B23, Numatrin) (NPM1) interaction partners

  1. The levels of B23 expression are directly regulated by EGR1 (show EGR1 Proteins).

  2. IDH2 (show IDH2 Proteins) and NPM1 (show GJA1 Proteins) mutations synergize in the development and maintenance of acute myeloid leukemia (show BCL11A Proteins) stem-like cells.

  3. Lrrc34, a novel nucleolar protein (show MCRS1 Proteins), interacts with npm1 (show GJA1 Proteins) and ncl (show NCL Proteins) and has an impact on pluripotent stem cells

  4. a function of NPM1 (show GJA1 Proteins) in the spatial organization of nucleolus-associated heterochromatin through DNA methyltransferase (show DNMT1 Proteins) DNMT3A (show DNMT3A Proteins)

  5. The data presented here support a novel role for NPM1 (show GJA1 Proteins) as a multilevel modulator of the base excision repair pathway.

  6. The mechanism of G-CSF's neuroprotection may be related in part to attenuating neuronal apoptosis by NPM1 (show GJA1 Proteins).

  7. In conclusion, we successfully established xenotransplantation model of human FLT3 (show FLT3 Proteins)-ITD (mut (show MUT Proteins)) /NPM1 (show GJA1 Proteins) (-) CN-AML (show RUNX1 Proteins) in NOD/SCID (show PRKDC Proteins) mice.

  8. This in vivo model of Flt3 (show FLT3 Proteins)/ITD+/NPMc+ leukemia closely recapitulates human disease and will therefore serve as a tool for the investigation of the biology of this common disease entity

  9. HOPS acts as a functional bridge in the interaction between NPM and p19(Arf)

  10. NPM-Bax (show BAX Proteins) interaction enhances mitochondrial Bax (show BAX Proteins) accumulation, organelle injury, and cell death.

Fruit Fly (Drosophila melanogaster) Nucleophosmin (Nucleolar phosphoprotein B23, Numatrin) (NPM1) interaction partners

  1. NLP is essential for the positioning of centromeres during cell division in Drosophila.

Nucleophosmin (Nucleolar phosphoprotein B23, Numatrin) (NPM1) Protein Profile

Protein Summary

This gene encodes a phosphoprotein which moves between the nucleus and the cytoplasm. The gene product is thought to be involved in several processes including regulation of the ARF/p53 pathway. A number of genes are fusion partners have been characterized, in particular the anaplastic lymphoma kinase gene on chromosome 2. Mutations in this gene are associated with acute myeloid leukemia. More than a dozen pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants.

Gene names and symbols associated with NPM1

  • nucleophosmin-like (LOC100059112)
  • nucleophosmin/nucleoplasmin, 1b (npm1b)
  • Nucleophosmin (npm)
  • nucleophosmin (nucleolar phosphoprotein B23, numatrin) (NPM1)
  • nucleophosmin (nucleolar phosphoprotein B23, numatrin) (npm1)
  • nucleophosmin (nucleolar phosphoprotein B23, numatrin) (Npm1)
  • nucleophosmin 1 (Npm1)
  • nucleophosmin-like (LOC100525313)
  • Nucleoplasmin (Nlp)
  • B23 protein
  • B23NP protein
  • CG7917 protein
  • Crp1 protein
  • Dmel\\CG7917 protein
  • dNLP protein
  • dNLP-S protein
  • NO38 protein
  • Npm protein
  • npm4 protein
  • p22 protein

Protein level used designations for NPM1

nucleophosmin , nucleophosmin/nucleoplasmin, 4 , Nucleophosmin , nucleolar protein NO38 , nucleophosmin/nucleoplasmin family, member 1 , NPM , nucleolar phosphoprotein B23 , nucleoplasmin , numatrin , nucleolar protein B23.1 , nucleophosmin 1 , CG7917-PA , CG7917-PB , Nlp-PA , Nlp-PB , Nucleoplasmin-like , chromatin decondensation protein 1 , nucleoplasmin-1

GENE ID SPECIES
100059112 Equus caballus
553507 Danio rerio
100195119 Salmo salar
4869 Homo sapiens
379194 Xenopus laevis
396203 Gallus gallus
25498 Rattus norvegicus
479292 Canis lupus familiaris
614028 Bos taurus
100328693 Oryctolagus cuniculus
740704 Pan troglodytes
18148 Mus musculus
100525313 Sus scrofa
43560 Drosophila melanogaster
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