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Functions as a redox-dependent negative regulator of the Wnt signaling pathway, possibly by preventing ubiquitination of DVL3 by the BCR(KLHL12) complex. Additionally we are shipping Nucleoredoxin Proteins (11) and Nucleoredoxin Kits (6) and many more products for this protein.
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Human Polyclonal NXN Primary Antibody for EIA, IHC (p) - ABIN953775
Funato, Miki: Nucleoredoxin, a novel thioredoxin family member involved in cell growth and differentiation. in Antioxidants & redox signaling 2007
Show all 4 references for ABIN953775
These results reveal a novel role of NRX in the regulation of PFK1 activity and in the balance between glycolysis and the pentose phosphate pathway.
NRX retains a pool of inactive Dishevelled (show DVL2 Antibodies) for robust activation of Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) signaling upon Wnt (show WNT2 Antibodies) stimulation.
Nucleoredoxin negatively regulates Toll-like receptor 4 (show TLR4 Antibodies) signaling via recruitment of flightless-I to myeloid differentiation primary response (show GADD45B Antibodies) gene
These data suggest a relationship between the Wnt (show WNT2 Antibodies)-beta-catenin (show CTNNB1 Antibodies) pathway and redox signalling through redox-sensitive association of NRX with Dvl (show DVL1 Antibodies).
formation of a complex between GST-nucleoredoxin, protein phosphatase 2A (PP2A (show PPP2R2B Antibodies)) (C) and PP2A (show PPP2R2B Antibodies)(D) was demonstrated by pull-down experiments
identified nucleoredoxin as an interaction partner of Sec63 (show SEC63 Antibodies); characterized this interaction; Sec63 (show SEC63 Antibodies) is linked to the Wnt (show WNT2 Antibodies) signaling pathways and this interaction may be the reason why mutations in SEC63 (show SEC63 Antibodies) can lead to polycystic liver disease
Nucleoredoxin is a novel thioredoxin (show TXN Antibodies) family member involved in cell growth and differentiation [review]
Nucleoredoxin regulates the Wnt (show WNT2 Antibodies)/planar cell polarity pathway in Xenopus.
Functions as a redox-dependent negative regulator of the Wnt signaling pathway, possibly by preventing ubiquitination of DVL3 by the BCR(KLHL12) complex. May also function as a transcriptional regulator act as a regulator of protein phosphatase 2A (PP2A) (By similarity).
, nucleoredoxin-like 2
, protein Red-1
, nucleoredoxin 1