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Functions as a redox-dependent negative regulator of the Wnt signaling pathway, possibly by preventing ubiquitination of DVL3 by the BCR(KLHL12) complex. Additionally we are shipping Nucleoredoxin Antibodies (39) and Nucleoredoxin Kits (6) and many more products for this protein.
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These results reveal a novel role of NRX in the regulation of PFK1 activity and in the balance between glycolysis and the pentose phosphate pathway.
NRX retains a pool of inactive Dishevelled (show DVL2 Proteins) for robust activation of Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling upon Wnt (show WNT2 Proteins) stimulation.
Nucleoredoxin negatively regulates Toll-like receptor 4 (show TLR4 Proteins) signaling via recruitment of flightless-I to myeloid differentiation primary response (show GADD45B Proteins) gene
These data suggest a relationship between the Wnt (show WNT2 Proteins)-beta-catenin (show CTNNB1 Proteins) pathway and redox signalling through redox-sensitive association of NRX with Dvl (show DVL1 Proteins).
formation of a complex between GST-nucleoredoxin, protein phosphatase 2A (PP2A (show PPP2R2B Proteins)) (C) and PP2A (show PPP2R2B Proteins)(D) was demonstrated by pull-down experiments
identified nucleoredoxin as an interaction partner of Sec63 (show SEC63 Proteins); characterized this interaction; Sec63 (show SEC63 Proteins) is linked to the Wnt (show WNT2 Proteins) signaling pathways and this interaction may be the reason why mutations in SEC63 (show SEC63 Proteins) can lead to polycystic liver disease
Nucleoredoxin is a novel thioredoxin (show TXN Proteins) family member involved in cell growth and differentiation [review]
Nucleoredoxin regulates the Wnt (show WNT2 Proteins)/planar cell polarity pathway in Xenopus.
Functions as a redox-dependent negative regulator of the Wnt signaling pathway, possibly by preventing ubiquitination of DVL3 by the BCR(KLHL12) complex. May also function as a transcriptional regulator act as a regulator of protein phosphatase 2A (PP2A) (By similarity).
, nucleoredoxin-like 2
, protein Red-1
, nucleoredoxin 1