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Misincorporation of oxidized nucleoside triphosphates into DNA/RNA during replication and transcription can cause mutations that may result in carcinogenesis or neurodegeneration. Additionally we are shipping NUDT1 Proteins (18) and NUDT1 Kits (4) and many more products for this protein.
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Human Polyclonal NUDT1 Primary Antibody for ICC, IF - ABIN151036
Takeshita, Ogawa, Asamoto, Shirai: Mechanistic approach of contrasting modifying effects of caffeine on carcinogenesis in the rat colon and mammary gland induced with 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine. in Cancer letters 2003
Show all 12 references for ABIN151036
activity of MTH1 in different breast cancer cell lines has been detected, implying the potential application of this assay method for biomedical research and clinical diagnose in the future
a novel approach involving liquid chromatography-isotope-dilution tandem mass spectrometry to positively identify and accurately quantify MTH1 in human tissues, is reported.
MTH1 is the most prominent sanitizer of the cellular dNTP pool known to date.
MTH1 expression is required for effective transformation of epithelial cells by oncogenic HRAS (show HRAS Antibodies).
Results show that MTH1 plays no role in protecting the cells against ultraviolet radiation-induced cytogenetic damage.
Results suggest that the hMTH1-mediated maintenance of mtDNA stability protects cells from the susceptibility to oxidant injury associated with polyQ-expanded Htt (show HTT Antibodies), defends against 3-nitropropionic acid-induced neurodegeneration
results indicate MTH1 is a novel and critical component of oncogenic KRAS-associated malignancy and its inhibition is likely to yield significant tumor-suppressive outcomes in KRAS-driven tumors.
The ectopic expression of hMTH1 in the chloroplasts and mitochondria of Arabidopsis enhanced oxidative stress tolerance by activating the poly(ADP-ribosyl)ation (PAR (show JTB Antibodies))reaction and suppressing programmed cell death.
cancer cells require MTH1 activity to avoid incorporation of oxidized dNTPs, resulting in DNA damage and cell death; validation of MTH1 as an anticancer target in vivo
MTH1 protects cells from mutagenesis induced by ultraviolet ray A and B, but not ultraviolet ray C.hMTH1 prevents induction of transition-type mutations at AT and GC post ultraviolet ray A irradiation.
These results suggest that MTH1 deficiency might be a causative factor for aging and age-related disorders.
MTH1 protects cells from H2O2-induced cell dysfunction and death by hydrolyzing oxidized purine nucleotides including 8-oxo-dGTP and 2-OH-dATP.
MTH1 efficiently suppresses the accumulation of 8-oxoG in both cellular DNA and RNA in the hippocampus, especially in microglia, caused by excitotoxicity.
Misincorporation of oxidized nucleoside triphosphates into DNA/RNA during replication and transcription can cause mutations that may result in carcinogenesis or neurodegeneration. The protein encoded by this gene is an enzyme that hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP, 8-oxo-dATP, 2-hydroxy-dATP, and 2-hydroxy rATP, to monophosphates, thereby preventing misincorporation. The encoded protein is localized mainly in the cytoplasm, with some in the mitochondria, suggesting that it is involved in the sanitization of nucleotide pools both for nuclear and mitochondrial genomes. Several alternatively spliced transcript variants, some of which encode distinct isoforms, have been identified. Additional variants have been observed, but their full-length natures have not been determined. A single-nucleotide polymorphism that results in the production of an additional, longer isoform (p26) has been described.
, 2-hydroxy-dATP diphosphatase
, 8-oxo-7,8-dihydrodeoxyguanosine triphosphatase
, 8-oxo-7,8-dihydroguanosine triphosphatase
, mutT human homolog 1
, nucleoside diphosphate-linked moiety X motif 1
, nucleoside diphosphate-linked moiety X-type motif 1
, nudix motif 1
, mutT human homolog (8-oxo-dGTPase)
, nudix-type motif 1