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Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 1 (NUDT1) ELISA Kits

Misincorporation of oxidized nucleoside triphosphates into DNA/RNA during replication and transcription can cause mutations that may result in carcinogenesis or neurodegeneration. Additionally we are shipping NUDT1 Antibodies (47) and NUDT1 Proteins (18) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
NUDT1 4521 P36639
NUDT1 17766 P53368
NUDT1 117260 P53369
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Top NUDT1 ELISA Kits at antibodies-online.com

Showing 3 out of 4 products:

Catalog No. Reactivity Sensitivity Range Quantity Supplier Delivery Price Details
Human 0.78-50 ng/mL 96 Tests Log in to see 11 to 13 Days
$946.00
Details
Mouse
96 Tests Log in to see 11 to 13 Days
$946.00
Details
Rat
96 Tests Log in to see 11 to 13 Days
$946.00
Details

More ELISA Kits for NUDT1 Interaction Partners

Human Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 1 (NUDT1) interaction partners

  1. activity of MTH1 in different breast cancer cell lines has been detected, implying the potential application of this assay method for biomedical research and clinical diagnose in the future

  2. a novel approach involving liquid chromatography-isotope-dilution tandem mass spectrometry to positively identify and accurately quantify MTH1 in human tissues, is reported.

  3. MTH1 is the most prominent sanitizer of the cellular dNTP pool known to date.

  4. MTH1 expression is required for effective transformation of epithelial cells by oncogenic HRAS (show HRAS ELISA Kits).

  5. Results show that MTH1 plays no role in protecting the cells against ultraviolet radiation-induced cytogenetic damage.

  6. Results suggest that the hMTH1-mediated maintenance of mtDNA stability protects cells from the susceptibility to oxidant injury associated with polyQ-expanded Htt (show HTT ELISA Kits), defends against 3-nitropropionic acid-induced neurodegeneration

  7. results indicate MTH1 is a novel and critical component of oncogenic KRAS-associated malignancy and its inhibition is likely to yield significant tumor-suppressive outcomes in KRAS-driven tumors.

  8. The ectopic expression of hMTH1 in the chloroplasts and mitochondria of Arabidopsis enhanced oxidative stress tolerance by activating the poly(ADP-ribosyl)ation (PAR (show JTB ELISA Kits))reaction and suppressing programmed cell death.

  9. cancer cells require MTH1 activity to avoid incorporation of oxidized dNTPs, resulting in DNA damage and cell death; validation of MTH1 as an anticancer target in vivo

  10. MTH1 protects cells from mutagenesis induced by ultraviolet ray A and B, but not ultraviolet ray C.hMTH1 prevents induction of transition-type mutations at AT and GC post ultraviolet ray A irradiation.

Mouse (Murine) Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 1 (NUDT1) interaction partners

  1. These results suggest that MTH1 deficiency might be a causative factor for aging and age-related disorders.

  2. MTH1 protects cells from H2O2-induced cell dysfunction and death by hydrolyzing oxidized purine nucleotides including 8-oxo-dGTP and 2-OH-dATP.

  3. MTH1 efficiently suppresses the accumulation of 8-oxoG in both cellular DNA and RNA in the hippocampus, especially in microglia, caused by excitotoxicity.

NUDT1 Antigen Profile

Antigen Summary

Misincorporation of oxidized nucleoside triphosphates into DNA/RNA during replication and transcription can cause mutations that may result in carcinogenesis or neurodegeneration. The protein encoded by this gene is an enzyme that hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP, 8-oxo-dATP, 2-hydroxy-dATP, and 2-hydroxy rATP, to monophosphates, thereby preventing misincorporation. The encoded protein is localized mainly in the cytoplasm, with some in the mitochondria, suggesting that it is involved in the sanitization of nucleotide pools both for nuclear and mitochondrial genomes. Several alternatively spliced transcript variants, some of which encode distinct isoforms, have been identified. Additional variants have been observed, but their full-length natures have not been determined. A single-nucleotide polymorphism that results in the production of an additional, longer isoform (p26) has been described.

Gene names and symbols associated with NUDT1

  • 7,8-dihydro-8-oxoguanine triphosphatase (mth1) antibody
  • 7,8-dihydro-8-oxoguanine triphosphatase (Tsp_07498) antibody
  • 7,8-dihydro-8-oxoguanine triphosphatase (8odp) antibody
  • nudix (nucleoside diphosphate linked moiety X)-type motif 1 (NUDT1) antibody
  • nudix (nucleoside diphosphate linked moiety X)-type motif 1 (Nudt1) antibody
  • Mth1 antibody
  • mutT antibody
  • nudT1 antibody

Protein level used designations for NUDT1

7,8-dihydro-8-oxoguanine triphosphatase , 2-hydroxy-dATP diphosphatase , 8-oxo-7,8-dihydrodeoxyguanosine triphosphatase , 8-oxo-7,8-dihydroguanosine triphosphatase , 8-oxo-dGTPase , mutT human homolog 1 , nucleoside diphosphate-linked moiety X motif 1 , nucleoside diphosphate-linked moiety X-type motif 1 , nudix motif 1 , 8-oxo-7,8-dihydro-2'-dGTPase , mutT human homolog (8-oxo-dGTPase) , nudix-type motif 1

GENE ID SPECIES
8791327 Azospirillum sp. B510
10901982 Trichinella spiralis
100195837 Salmo salar
100305248 Oncorhynchus mykiss
4521 Homo sapiens
17766 Mus musculus
117260 Rattus norvegicus
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