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Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 15 Proteins (NUDT15)

Mediates the hydrolysis of some nucleoside diphosphate derivatives. Additionally we are shipping NUDT15 Antibodies (25) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
NUDT15 55270 Q9NV35
NUDT15 214254 Q8BG93
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Top NUDT15 Proteins at antibodies-online.com

Showing 3 out of 3 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

NUDT15 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,

Mouse (Murine)

More Proteins for Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 15 (NUDT15) Interaction Partners

Human Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 15 (NUDT15) interaction partners

  1. NUDT15 c.415C>T increases risk of 6-mercaptopurine induced myelosuppression during maintenance therapy in children with acute lymphoblastic leukemia.

  2. Patients with defective NUDT15 alleles showed excessive levels of thiopurine active metabolites and toxicity. [meta-analysis]

  3. Depletion of NUDT15 has no effect on incorporation of 8-oxo-dGTP into DNA and does not impact cancer cell survival in cell lines tested. NUDT15 is not a biologically relevant 8-oxo-dGTPase (show NUDT1 Proteins)

  4. Event-free survival did not significantly differ by NUDT15 genotype. rs116855232 is an important determinant of 6-MP myelotoxicity in Japanese children with ALL and may represent the most robust toxicity-related locus in Asians to date.

  5. Describe a germline variant in NUDT15 strongly associated with mercaptopurine intolerance in childhood acute lymphoblastic leukemia, which may have implications for treatment individualization in this disease.

  6. Authros identified a nonsynonymous SNP in NUDT15 (encoding p.Arg139Cys) that was strongly associated with thiopurine-induced early leukopenia (odds ratio (OR) = 35.6; P(combined) = 4.88 x 10(-94)).

  7. human MTH1, MTH2, and NUDT5 proteins act as a defense against the mutagenesis induced by oxidized dGTP.

  8. Data demonstrate for the first time that PCNA (show PCNA Proteins) is protected by this newly identified partner molecule MTH2, which is related to DNA synthesis and cell cycle progression.

Mouse (Murine) Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 15 (NUDT15) interaction partners

  1. These results suggest that the MTH2 deficiency might be one of the causative factors for accelerated aging.

  2. MTH2 has a potential to protect the genetic material from the untoward effects of endogenous oxygen radicals; MTH2 could act as an MTH1 (show NUDT1 Proteins) redundancy factor [MTH2]

NUDT15 Protein Profile

Protein Summary

Mediates the hydrolysis of some nucleoside diphosphate derivatives. Can degrade 8-oxo-dGTP in vitro, suggesting that it may remove an oxidatively damaged form of guanine (7,8-dihydro-8- oxoguanine) from DNA and the nucleotide pool, thereby preventing misincorporation of 8-oxo-dGTP into DNA thus preventing A:T to C:G transversions. Its substrate specificity in vivo however remains unclear. May have a role in DNA synthesis and cell cycle progression through the interaction with PCNA.

Gene names and symbols associated with NUDT15

  • nudix (nucleoside diphosphate linked moiety X)-type motif 15 (NUDT15)
  • nudix (nucleoside diphosphate linked moiety X)-type motif 15 (Nudt15)
  • 6530403O17 protein
  • A730068G11Rik protein
  • MTH2 protein
  • RP11-90M2.1 protein

Protein level used designations for NUDT15

7,8-dihydro-8-oxoguanine-triphosphatase NUDT15 , 8-oxo-dGTPase NUDT15 , A730068G11Rik , mutT homolog 2 , nucleoside diphosphate-linked moiety X motif 15 , nudix motif 15 , nudix-type motif 15 , probable 7,8-dihydro-8-oxoguanine triphosphatase NUDT15 , probable 8-oxo-dGTP diphosphatase NUDT15 , MutT homolog 2 , mMTH2

GENE ID SPECIES
55270 Homo sapiens
214254 Mus musculus
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