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Misincorporation of oxidized nucleoside triphosphates into DNA/RNA during replication and transcription can cause mutations that may result in carcinogenesis or neurodegeneration. Additionally we are shipping NUDT1 Antibodies (61) and NUDT1 Kits (7) and many more products for this protein.
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MTH1 together with MYH (show MUTYH Proteins) plays an important role in protection against mutations induced by modified dNTPs during chronic oxidative stress.
Reduced MUTYH (show MUTYH Proteins), MTH1, and OGG1 (show OGG1 Proteins) expression and TP53 (show TP53 Proteins) mutations occur in diffuse-type adenocarcinoma of gastric cardia.
Analyses of bond lengths with high-resolution X-ray data and the relationship between the structure and enzymatic activity revealed that hMTH1 recognizes the different oxidized nucleotides via an exchange of the protonation state at two neighboring aspartate residues (Asp (show ASIP Proteins)-119 and Asp (show ASIP Proteins)-120) in its substrate binding pocket
MTH1 inhibition may offer a general approach to treat cancers characterized by deregulated hypoxia signaling or redox imbalance
MTH-1 expression in colorectal cancer cells was upregulated via HIF-1alpha (show HIF1A Proteins) in response to hypoxic stress, emphasizing the crucial role of HIF-1alpha (show HIF1A Proteins)-induced MTH-1 in tumor growth.
activity of MTH1 in different breast cancer cell lines has been detected, implying the potential application of this assay method for biomedical research and clinical diagnose in the future
a novel approach involving liquid chromatography-isotope-dilution tandem mass spectrometry to positively identify and accurately quantify MTH1 in human tissues, is reported.
MTH1 is the most prominent sanitizer of the cellular dNTP pool known to date.
MTH1 expression is required for effective transformation of epithelial cells by oncogenic HRAS (show HRAS Proteins).
Results show that MTH1 plays no role in protecting the cells against ultraviolet radiation-induced cytogenetic damage.
These results suggest that MTH1 deficiency might be a causative factor for aging and age-related disorders.
MTH1 protects cells from H2O2-induced cell dysfunction and death by hydrolyzing oxidized purine nucleotides including 8-oxo-dGTP and 2-OH-dATP.
MTH1 efficiently suppresses the accumulation of 8-oxoG in both cellular DNA and RNA in the hippocampus, especially in microglia, caused by excitotoxicity.
Misincorporation of oxidized nucleoside triphosphates into DNA/RNA during replication and transcription can cause mutations that may result in carcinogenesis or neurodegeneration. The protein encoded by this gene is an enzyme that hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP, 8-oxo-dATP, 2-hydroxy-dATP, and 2-hydroxy rATP, to monophosphates, thereby preventing misincorporation. The encoded protein is localized mainly in the cytoplasm, with some in the mitochondria, suggesting that it is involved in the sanitization of nucleotide pools both for nuclear and mitochondrial genomes. Several alternatively spliced transcript variants, some of which encode distinct isoforms, have been identified. Additional variants have been observed, but their full-length natures have not been determined. A single-nucleotide polymorphism that results in the production of an additional, longer isoform (p26) has been described.
, 2-hydroxy-dATP diphosphatase
, 8-oxo-7,8-dihydrodeoxyguanosine triphosphatase
, 8-oxo-7,8-dihydroguanosine triphosphatase
, mutT human homolog 1
, nucleoside diphosphate-linked moiety X motif 1
, nucleoside diphosphate-linked moiety X-type motif 1
, nudix motif 1
, mutT human homolog (8-oxo-dGTPase)
, nudix-type motif 1