Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 1 Proteins (NUDT1)

Misincorporation of oxidized nucleoside triphosphates into DNA/RNA during replication and transcription can cause mutations that may result in carcinogenesis or neurodegeneration. Additionally we are shipping NUDT1 Antibodies (61) and NUDT1 Kits (7) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
NUDT1 4521 P36639
NUDT1 17766 P53368
NUDT1 117260 P53369
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Top NUDT1 Proteins at antibodies-online.com

Showing 10 out of 17 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 15 to 19 Days
$319.00
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 20 to 21 Days
$327.80
Details
HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days
$785.40
Details
Yeast Rat His tag   1 mg Log in to see 60 to 71 Days
$2,286.17
Details
HOST_Escherichia coli (E. coli) Human His tag   1 mg Log in to see 2 to 3 Days
$3,035.21
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 2 to 3 Days
$364.64
Details
Human Un-conjugated   5 μg Log in to see 6 Days
$168.54
Details

NUDT1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine)

Rat (Rattus)

More Proteins for Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 1 (NUDT1) Interaction Partners

Human Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 1 (NUDT1) interaction partners

  1. MTH1 together with MYH (show MUTYH Proteins) plays an important role in protection against mutations induced by modified dNTPs during chronic oxidative stress.

  2. Reduced MUTYH (show MUTYH Proteins), MTH1, and OGG1 (show OGG1 Proteins) expression and TP53 (show TP53 Proteins) mutations occur in diffuse-type adenocarcinoma of gastric cardia.

  3. Analyses of bond lengths with high-resolution X-ray data and the relationship between the structure and enzymatic activity revealed that hMTH1 recognizes the different oxidized nucleotides via an exchange of the protonation state at two neighboring aspartate residues (Asp (show ASIP Proteins)-119 and Asp (show ASIP Proteins)-120) in its substrate binding pocket

  4. MTH1 inhibition may offer a general approach to treat cancers characterized by deregulated hypoxia signaling or redox imbalance

  5. MTH-1 expression in colorectal cancer cells was upregulated via HIF-1alpha (show HIF1A Proteins) in response to hypoxic stress, emphasizing the crucial role of HIF-1alpha (show HIF1A Proteins)-induced MTH-1 in tumor growth.

  6. activity of MTH1 in different breast cancer cell lines has been detected, implying the potential application of this assay method for biomedical research and clinical diagnose in the future

  7. a novel approach involving liquid chromatography-isotope-dilution tandem mass spectrometry to positively identify and accurately quantify MTH1 in human tissues, is reported.

  8. MTH1 is the most prominent sanitizer of the cellular dNTP pool known to date.

  9. MTH1 expression is required for effective transformation of epithelial cells by oncogenic HRAS (show HRAS Proteins).

  10. Results show that MTH1 plays no role in protecting the cells against ultraviolet radiation-induced cytogenetic damage.

Mouse (Murine) Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 1 (NUDT1) interaction partners

  1. These results suggest that MTH1 deficiency might be a causative factor for aging and age-related disorders.

  2. MTH1 protects cells from H2O2-induced cell dysfunction and death by hydrolyzing oxidized purine nucleotides including 8-oxo-dGTP and 2-OH-dATP.

  3. MTH1 efficiently suppresses the accumulation of 8-oxoG in both cellular DNA and RNA in the hippocampus, especially in microglia, caused by excitotoxicity.

NUDT1 Protein Profile

Protein Summary

Misincorporation of oxidized nucleoside triphosphates into DNA/RNA during replication and transcription can cause mutations that may result in carcinogenesis or neurodegeneration. The protein encoded by this gene is an enzyme that hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP, 8-oxo-dATP, 2-hydroxy-dATP, and 2-hydroxy rATP, to monophosphates, thereby preventing misincorporation. The encoded protein is localized mainly in the cytoplasm, with some in the mitochondria, suggesting that it is involved in the sanitization of nucleotide pools both for nuclear and mitochondrial genomes. Several alternatively spliced transcript variants, some of which encode distinct isoforms, have been identified. Additional variants have been observed, but their full-length natures have not been determined. A single-nucleotide polymorphism that results in the production of an additional, longer isoform (p26) has been described.

Gene names and symbols associated with NUDT1

  • 7,8-dihydro-8-oxoguanine triphosphatase (mth1)
  • 7,8-dihydro-8-oxoguanine triphosphatase (Tsp_07498)
  • 7,8-dihydro-8-oxoguanine triphosphatase (8odp)
  • nudix (nucleoside diphosphate linked moiety X)-type motif 1 (NUDT1)
  • nudix (nucleoside diphosphate linked moiety X)-type motif 1 (Nudt1)
  • Mth1 protein
  • mutT protein
  • nudT1 protein

Protein level used designations for NUDT1

7,8-dihydro-8-oxoguanine triphosphatase , 2-hydroxy-dATP diphosphatase , 8-oxo-7,8-dihydrodeoxyguanosine triphosphatase , 8-oxo-7,8-dihydroguanosine triphosphatase , 8-oxo-dGTPase , mutT human homolog 1 , nucleoside diphosphate-linked moiety X motif 1 , nucleoside diphosphate-linked moiety X-type motif 1 , nudix motif 1 , 8-oxo-7,8-dihydro-2'-dGTPase , mutT human homolog (8-oxo-dGTPase) , nudix-type motif 1

GENE ID SPECIES
8791327 Azospirillum sp. B510
10901982 Trichinella spiralis
100195837 Salmo salar
100305248 Oncorhynchus mykiss
4521 Homo sapiens
17766 Mus musculus
117260 Rattus norvegicus
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