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ORAI Calcium Release-Activated Calcium Modulator 2 Proteins (ORAI2)

Ca(2+) release-activated Ca(2+)-like (CRAC-like) channel subunit which mediates Ca(2+) influx and increase in Ca(2+)- selective current by synergy with the Ca(2+) sensor, STIM1 (By similarity). Additionally we are shipping ORAI2 Antibodies (32) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Rat ORAI2 ORAI2 304592  
ORAI2 100043803  
ORAI2 80228 Q96SN7
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Top ORAI2 Proteins at antibodies-online.com

Showing 3 out of 3 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details

ORAI2 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human ,
,

More Proteins for ORAI Calcium Release-Activated Calcium Modulator 2 (ORAI2) Interaction Partners

Mouse (Murine) ORAI Calcium Release-Activated Calcium Modulator 2 (ORAI2) interaction partners

  1. The data from this study indicate that upregulation of STIM2 (show Stim2 Proteins) and Orai2 is involved in the phenotypic transition of pulmonary arterial smooth muscle cells from a contractile state to a proliferative state.

  2. Data indicate that the Ca(2 (show CA2 Proteins)+) release-activated Ca(2 (show CA2 Proteins)+) channels (CRAC) blocker GSK-7975A inhibited store-operated Ca(2 (show CA2 Proteins)+) entry in a concentration-dependent manner.

Human ORAI Calcium Release-Activated Calcium Modulator 2 (ORAI2) interaction partners

  1. Orai1, Orai2 and STIM1 (show STIM1 Proteins) form functional Ca(2 (show CA2 Proteins)+) release-activated Ca(2 (show CA2 Proteins)+) channels in OUMS-27 cells (chondrocytes) and that these complexes are responsible for sustained Ca(2 (show CA2 Proteins)+) entry in response to agonist stimulation.

  2. The higher amplitude of store-operated Ca2 (show CA2 Proteins)+ entry was associated to the over-expression for Stim2 (show Stim2 Proteins), Orai2-3, and TRPC1 (show TRPC1 Proteins) while Stim2 (show Stim2 Proteins) levels remained constant and Stim1 (show STIM1 Proteins), Orai1, Orai3, TRPC1 (show TRPC1 Proteins) and TRPC4 (show TRPC4 Proteins) proteins were over-expressed in primary myelofibrosis.

  3. Orai1 but not Orai2 plays a major role in the influx of extracellular Ca2 (show CA2 Proteins)+ into and mediator release from HLMCs following their activation

  4. Orai1 and Orai2 operate in a STIM-dependent manner, Orai3 does not interact with STIM isoforms upon calcium store depletion in platelets.

  5. With these data we show a new Ca(2 (show CA2 Proteins))(+) entry pathway linked to the Ca(2 (show CA2 Proteins))(+)/inositolphosphate second-messenger system in RPE (show RPE Proteins) cells which help to further understand regulatory pathways of agonists.

  6. Results suggest that Orai1, -2, and -3 channels are similarly inhibited by extracellular calcium, indicating similar affinities for Ca(2 (show CA2 Proteins)+) within the selectivity filter.

  7. The effects of 2-aminoethoxydiphenyl borate on orai1, orai2, orai3 metabolism in HEK293 cells with and without STIM1 (show STIM1 Proteins) are reported.

  8. analysis of activation of Orai1-3 channels by a STIM1 (show STIM1 Proteins) coiled-coil mutant

  9. Data show that the fast Ca(2+)-dependent inactivation is mediated by three conserved glutamates in the C termini (CT) of Orai2 and Orai3, which show prominent fast Ca(2+)-dependent inactivation compared with Orai1.

Cow (Bovine) ORAI Calcium Release-Activated Calcium Modulator 2 (ORAI2) interaction partners

  1. Orai2 is specifically up-regulated during the G2/M phase, negatively modulates the store-operated Ca(2 (show CA2 Proteins)+) entry activity, and may contribute to the regulation of cell cycle progression in brain capillary endothelial cells.

ORAI2 Protein Profile

Protein Summary

Ca(2+) release-activated Ca(2+)-like (CRAC-like) channel subunit which mediates Ca(2+) influx and increase in Ca(2+)- selective current by synergy with the Ca(2+) sensor, STIM1 (By similarity).

Gene names and symbols associated with ORAI2

  • ORAI calcium release-activated calcium modulator 2 (Orai2)
  • ORAI calcium release-activated calcium modulator 2 (ORAI2)
  • predicted gene 4659 (Gm4659)
  • ORAI calcium release-activated calcium modulator 2 (LOC100230993)
  • ORAI calcium release-activated calcium modulator 2 (LOC100349347)
  • ORAI calcium release-activated calcium modulator 2 (LOC100358487)
  • ORAI calcium release-activated calcium modulator 2 (LOC100359269)
  • ORAI calcium release-activated calcium modulator 2 (orai2)
  • A730041O15Rik protein
  • C7orf19 protein
  • CBCIP2 protein
  • LOC100230993 protein
  • MEM142B protein
  • Orai2 protein
  • RGD1310213 protein
  • Tmem142b protein

Protein level used designations for ORAI2

CAP-binding protein complex interacting protein 2 , calcium release-activated calcium modulator 2 protein , ORAI calcium release-activated calcium modulator 2 , calcium release-activated calcium channel 2 , CAP-binding protein complex-interacting protein 2 , H_NH0514P08.8 , protein orai-2 , putative protein ORAI2-2 , transmembrane protein 142B

GENE ID SPECIES
304592 Rattus norvegicus
463930 Pan troglodytes
100043803 Mus musculus
100230993 Taeniopygia guttata
100349347 Oryctolagus cuniculus
100358487 Oryctolagus cuniculus
100359269 Oryctolagus cuniculus
100380109 Xenopus (Silurana) tropicalis
80228 Homo sapiens
269717 Mus musculus
608106 Canis lupus familiaris
511233 Bos taurus
417509 Gallus gallus
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