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Key regulator or component of store-operated Ca(2+) channel and transcription factor NFAT nuclear import (By similarity).. Additionally we are shipping ORAI3 Antibodies (73) and and many more products for this protein.
Overall high Orai3/Orai1 (show ORAI1 ELISA Kits) ratios in human prostate epithelial cells and androgen-insensitive cancer cells contribute to their ROS (show ROS1 ELISA Kits) resistance and thereby may have a share in making the prostate one of the most prominent cancer susceptible organs
A channel chimera of Orai3 with the N terminus of Orai1 (show ORAI1 ELISA Kits) was able to couple local Ca(2 (show CA2 ELISA Kits)+) entry to NFAT (show NFATC1 ELISA Kits) activation, identifying the N-terminal domain of Orai1 (show ORAI1 ELISA Kits) as central to Ca(2 (show CA2 ELISA Kits)+) nanodomain-transcription coupling.
Orai3 down-tunes efficient STIM1 (show STIM1 ELISA Kits) gating when in a heteromeric complex with Orai1 (show ORAI1 ELISA Kits).
The higher amplitude of store-operated Ca2 (show CA2 ELISA Kits)+ entry was associated to the over-expression for Stim2 (show Stim2 ELISA Kits), Orai2 (show ORAI2 ELISA Kits)-3, and TRPC1 (show TRPC1 ELISA Kits) while Stim2 (show Stim2 ELISA Kits) levels remained constant and Stim1 (show STIM1 ELISA Kits), Orai1 (show ORAI1 ELISA Kits), Orai3, TRPC1 (show TRPC1 ELISA Kits) and TRPC4 (show TRPC4 ELISA Kits) proteins were over-expressed in primary myelofibrosis.
Orai3 constitutes a native store-operated calcium entry pathway in non small cell lung adenocarcinoma that controls cell proliferation and cell cycle progression, likely via Akt (show AKT1 ELISA Kits) pathway.
Orai1 (show ORAI1 ELISA Kits) and Orai3 proteins are more important than calcium influx to control cell proliferation.
High ORAI3 expression is associated with breast cancer.
data establish Orai3 as an ERalpha (show ESR1 ELISA Kits)-regulated channel and a potential selective therapeutic target for ERalpha (show ESR1 ELISA Kits)(+) breast cancers
the N-terminal conserved region plays a multifaceted role in Orai3 current gating with distinct structural requirements for STIM1 (show STIM1 ELISA Kits)- and 2-APB (show RNPEP ELISA Kits)-stimulated activation.
With these data we show a new Ca(2)(+) entry pathway linked to the Ca(2)(+)/inositolphosphate second-messenger system in RPE cells which help to further understand regulatory pathways of agonists.
VEGF (show VEGFA ELISA Kits) signaling via arachidonic acid and arachidonic acid metabolism causes Orai3 to accumulate at the cell surface to mediate Ca(2 (show CA2 ELISA Kits)+) entry and downstream endothelial cell remodeling.
Key regulator or component of store-operated Ca(2+) channel and transcription factor NFAT nuclear import (By similarity).
, ORAI calcium release-activated calcium modulator 3
, transmembrane protein 142C
, calcium release-activated calcium channel 3
, calcium release-activated calcium modulator 3 protein