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anti-ORAI Calcium Release-Activated Calcium Modulator 1 (ORAI1) Antibodies

The protein encoded by ORAI1 is a membrane calcium channel subunit that is activated by the calcium sensor STIM1 when calcium stores are depleted. Additionally we are shipping ORAI1 Kits (4) and and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
ORAI1 84876 Q96D31
ORAI1 109305 Q8BWG9
ORAI1 304496 Q5M848
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Top anti-ORAI1 Antibodies at antibodies-online.com

Showing 10 out of 118 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Horse Rabbit Un-conjugated WB WB Suggested Anti-ORAI1 Antibody Titration: 0.2-1 ug/mlPositive Control: HepG2 cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-ORAI1 Antibody Titration: 0.2-1 ug/mlPositive Control: HepG2 cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated WB ORAI1 Antibody (C-term) (ABIN658509) western blot analysis in A375 cell line lysates (35 µg/lane). This demonstrates the ORAI1 antibody detected the ORAI1 protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB Formalin-fixed and paraffin-embedded human prostate carcinoma reacted with ORAI1 Antibody (Center) followed which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. Western blot analysis of ORAI1 Antibody (Center) in A375 cell line and mouse testis tissue lysates (35ug/lane). ORAI1 (arrow) was detected using the purified Pab. 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated IHC (p), WB 0.1 mg Log in to see 6 to 8 Days
$434.50
Details
Human Goat Un-conjugated ELISA, WB ABIN334452 (0.03µg/ml) staining of Human Placenta lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 100 μg Log in to see 4 to 5 Days
$326.89
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB Immunohistochemistry of ORAI1 in human spleen tissue with this product at 2.5 μg/ml. Western blot analysis of ORAI1 in human ovary tissue lysate with this product at (A) 0.5, (B) 1 and (C) 2 μg/ml. 0.1 mg Log in to see 6 to 8 Days
$401.50
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB Immunohistochemistry of ORAI1 in human spleen tissue with this product at 10 μg/ml. Western blot analysis of ORAI1 in human ovary tissue lysate with this product at 1 μg/ml in the (A) absence or (B) presence of blocking peptide. 0.1 mg Log in to see 6 to 8 Days
$401.50
Details
Human Goat Un-conjugated WB 0.1 mg Log in to see 6 to 8 Days
$379.50
Details
Human Mouse Un-conjugated ELISA, ICC, IF, IHC, IHC (p), WB Immunohistochemistry: Orai1 Antibody (3F6H5) [NBP1-75522] - ORAI1 in human spleen tissue with ORAI1 antibody at 2.5 ug/mL Western Blot: Orai1 Antibody (3F6H5) [NBP1-75522] - analysis of ORAI1 in human ovary tissue lysate with ORAI1 antibody at (A) 1 and (B) 2 ug/mL. 0.1 mg Log in to see 8 to 11 Days
$447.56
Details

ORAI1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-ORAI1 Antibodies

  1. Human Polyclonal ORAI1 Primary Antibody for WB - ABIN658509 : Feng, Grice, Faddy, Nguyen, Leitch, Wang, Muend, Kenny, Sukumar, Roberts-Thomson, Monteith, Rao: Store-independent activation of Orai1 by SPCA2 in mammary tumors. in Cell 2010 (PubMed)
    Show all 4 references for ABIN658509

  2. Human Polyclonal ORAI1 Primary Antibody for EIA, IHC (p) - ABIN953931 : Calloway, Holowka, Baird: A basic sequence in STIM1 promotes Ca2+ influx by interacting with the C-terminal acidic coiled coil of Orai1. in Biochemistry 2010 (PubMed)
    Show all 3 references for ABIN953931

  3. Human Polyclonal ORAI1 Primary Antibody for IHC (p), WB - ABIN318921 : Lewis: Calcium signaling mechanisms in T lymphocytes. in Annual review of immunology 2001 (PubMed)
    Show all 2 references for ABIN318921

  4. Human Polyclonal ORAI1 Primary Antibody for WB - ABIN375074 : Vig, DeHaven, Bird, Billingsley, Wang, Rao, Hutchings, Jouvin, Putney, Kinet: Defective mast cell effector functions in mice lacking the CRACM1 pore subunit of store-operated calcium release-activated calcium channels. in Nature immunology 2007 (PubMed)

  5. Human Monoclonal ORAI1 Primary Antibody for ELISA, ICC - ABIN4341596 : Ávila-Medina, Calderón-Sánchez, González-Rodríguez, Monje-Quiroga, Rosado, Castellano, Ordóñez, Smani: Orai1 and TRPC1 Proteins Co-localize with CaV1.2 Channels to Form a Signal Complex in Vascular Smooth Muscle Cells. in The Journal of biological chemistry 2016 (PubMed)

  6. Horse (Equine) Polyclonal ORAI1 Primary Antibody for WB - ABIN2784057 : Peel, Liu, Hall: ORAI and store-operated calcium influx in human airway smooth muscle cells. in American journal of respiratory cell and molecular biology 2008 (PubMed)

More Antibodies against ORAI1 Interaction Partners

Zebrafish ORAI Calcium Release-Activated Calcium Modulator 1 (ORAI1) interaction partners

  1. Orai1 is localized to the cleavage furrow during cytokinesis of the first and second cell division cycles in zebrafish embryos.

  2. The findings identify ORAI1 as an important regulator of cardiac and skeletal muscle function and provide evidence linking ORAI1-mediated calcium signaling to sarcomere integrity and cardiomyocyte function.

Xenopus laevis ORAI Calcium Release-Activated Calcium Modulator 1 (ORAI1) interaction partners

  1. The Orai1 actively recycles between an endosomal compartment and the cell membrane through a Rho-dependent endocytic pathway.

Silk Worm ORAI Calcium Release-Activated Calcium Modulator 1 (ORAI1) interaction partners

  1. STIM1 (show STIM1 Antibodies) and Orai1 are essential components of the signal transduction cascade that regulates sex pheromone production.

Human ORAI Calcium Release-Activated Calcium Modulator 1 (ORAI1) interaction partners

  1. CRAC channel functions as a hexamer of Orai1 subunits

  2. A novel heterozygous c.290C>G (p.S97C) mutation in ORAI1 causing a mild- and late-onset tubular aggregate myopathy and congenital miosis via constitutive activation of the CRAC channel.

  3. What is less clear is how the spatial and temporal spread of intracellular Ca(2 (show CA2 Antibodies)+) is shaped and regulated by differential expression of the individual SOCE genes and their splice variants, their heteromeric combinations and pre- and posttranslational modifications. This review focuses on principle mechanisms regulating expression, splicing, and targeting of Ca(2 (show CA2 Antibodies)+) release-activated Ca(2 (show CA2 Antibodies)+) (CRAC) channels.

  4. The focus is on the activation of the STIM proteins, the subsequent coupling of STIM1 (show STIM1 Antibodies) to Orai1, and the consequent structural rearrangements that gate the Orai channels into the open state to allow Ca(2 (show CA2 Antibodies)+)permeation into the cell. [review]

  5. results argue strongly against a tetrameric configuration for Orai1 channels and indicate that the Orai1 channel functions as a hexamer.

  6. APP (show APP Antibodies) does not modulate Orai-dependent store-operated calcium entry following quantitative calcium store depletion.

  7. Orai1 regulates osteogenic differentiation through BMP signaling, and the Orai1-BMP signaling may be a possible therapeutic target for treating bone-related diseases.

  8. Orai1-mediated Ca(2 (show CA2 Antibodies)+)-influx and SPCA2 (show ATP2C2 Antibodies)-mediated Ca(2 (show CA2 Antibodies)+) uptake activity into the Golgi/secretory pathway might be coupled possibly in a microdomain. This channel/pump complex may efficiently transfer Ca(2 (show CA2 Antibodies)+) into the secretory pathway, which might play a role in SPCA2 (show ATP2C2 Antibodies)-expressing secretory cells, such as mammary gland during lactation.

  9. This study may lay the foundation for finding novel lead compounds for clinical trials that could positively modulate the course of autoimmune disorders with ORAI1 as its specific target.

  10. Mutations in the STIM1 (show STIM1 Antibodies) and ORAI1 genes cause calcium dyshomeostasis in tubular aggregate myopathy. (Review)

Mouse (Murine) ORAI Calcium Release-Activated Calcium Modulator 1 (ORAI1) interaction partners

  1. these data indicate for the first time a functional interaction between Orai1 (show TMEM132A Antibodies), TRPC1 (show TRPC1 Antibodies), and CaV1.2 (show CACNA1C Antibodies) channels in Vascular Smooth Muscle Cells, confirming that upon agonist stimulation, vessel contraction involves Ca(2 (show CA2 Antibodies)+) entry due to co-activation of Orai1 (show TMEM132A Antibodies)- and TRPC1 (show TRPC1 Antibodies)-dependent store-operated Ca(2 (show CA2 Antibodies)+) channels and L-type Ca(2 (show CA2 Antibodies)+) channels.

  2. reveal that Orai1 (show TMEM132A Antibodies)(-/-) male mice are sterile and have severe defects in spermatogenesis, with prominent deficiencies in mid- to late-stage elongating spermatid development

  3. In Dicer (show DICER1 Antibodies)-deficient mice Orai1 (show TMEM132A Antibodies) was down-regulated at mRNA and protein level in CD4 (show CD4 Antibodies)+ T cells.

  4. results identified the ORAI-NOX2 (show CYBB Antibodies) feedback loop as a determinant of monocyte immune responses.

  5. Orai1 (show TMEM132A Antibodies)-dependent Ca(2 (show CA2 Antibodies)+) entry promotes atherogenesis possibly by promoting foam cell formation and vascular inflammation, rendering orai1 (show TMEM132A Antibodies) Ca(2 (show CA2 Antibodies)+) channel a potential therapeutic target against atherosclerosis.

  6. alternative translation initiation of the Orai1 (show TMEM132A Antibodies) message produces at least three types of Ca(2 (show CA2 Antibodies)+) channels with distinct signaling and regulatory properties.

  7. Orai1 (show TMEM132A Antibodies) and STIM1 (show STIM1 Antibodies) have roles in inhibiting matrix protein expression

  8. SOCE blockers or ablation of STIM1 (show STIM1 Antibodies), STIM2 (show Stim2 Antibodies), or Orai1 (show TMEM132A Antibodies) severely impaired nucleotide-induced migration and phagocytosis in microglia.

  9. Our data establish Orai1 (show TMEM132A Antibodies) as key signal mediator of C5aR (show C5AR1 Antibodies) activation, contributing to inflammation

  10. Orai1 (show TMEM132A Antibodies) store-operated calcium channels have an essential role in lactation

ORAI1 Antigen Profile

Protein Summary

The protein encoded by this gene is a membrane calcium channel subunit that is activated by the calcium sensor STIM1 when calcium stores are depleted. This type of channel is the primary way for calcium influx into T-cells. Defects in this gene are a cause of immune dysfunction with T-cell inactivation due to calcium entry defect type 1 (IDTICED1).

Gene names and symbols associated with ORAI1

  • ORAI calcium release-activated calcium modulator 1b (orai1b) antibody
  • ORAI calcium release-activated calcium modulator 1 (orai1) antibody
  • ORAI calcium release-activated calcium modulator 1 (ORAI1) antibody
  • ORAI calcium release-activated calcium modulator 1 (Orai1) antibody
  • ORAI calcium release-activated calcium modulator 1 (LOC100218031) antibody
  • ORAI calcium release-activated calcium modulator 2 (orai2) antibody
  • CRACM1 antibody
  • D730049H07Rik antibody
  • im:7146264 antibody
  • LOC100218031 antibody
  • orai-1 antibody
  • ORAI1 antibody
  • orai2 antibody
  • ORAT1 antibody
  • RGD1311873 antibody
  • Tmem142a antibody
  • tmem142b antibody
  • zgc:109721 antibody

Protein level used designations for ORAI1

ORAI calcium release-activated calcium modulator 1 , calcium release-activated calcium channel protein 1 , protein orai-1 , transmembrane protein 142A , protein orai-2 , transmembrane protein 142B , calcium release-activated calcium modulator 1 , calcium release-activated calcium channel 1

GENE ID SPECIES
402892 Danio rerio
403390 Xenopus laevis
473293 Pan troglodytes
700190 Macaca mulatta
100125061 Xenopus (Silurana) tropicalis
100188931 Bombyx mori
100218031 Taeniopygia guttata
84876 Homo sapiens
486261 Canis lupus familiaris
100154923 Sus scrofa
517688 Bos taurus
109305 Mus musculus
304496 Rattus norvegicus
416845 Gallus gallus
734537 Xenopus laevis
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