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The protein encoded by ORAI1 is a membrane calcium channel subunit that is activated by the calcium sensor STIM1 when calcium stores are depleted. Additionally we are shipping ORAI1 Kits (4) and and many more products for this protein.
Showing 10 out of 118 products:
Human Polyclonal ORAI1 Primary Antibody for WB - ABIN658509
Feng, Grice, Faddy, Nguyen, Leitch, Wang, Muend, Kenny, Sukumar, Roberts-Thomson, Monteith, Rao: Store-independent activation of Orai1 by SPCA2 in mammary tumors. in Cell 2010
Show all 4 references for ABIN658509
Human Polyclonal ORAI1 Primary Antibody for EIA, IHC (p) - ABIN953931
Calloway, Holowka, Baird: A basic sequence in STIM1 promotes Ca2+ influx by interacting with the C-terminal acidic coiled coil of Orai1. in Biochemistry 2010
Show all 3 references for ABIN953931
Human Polyclonal ORAI1 Primary Antibody for IHC (p), WB - ABIN318921
Lewis: Calcium signaling mechanisms in T lymphocytes. in Annual review of immunology 2001
Show all 2 references for ABIN318921
Human Polyclonal ORAI1 Primary Antibody for WB - ABIN375074
Vig, DeHaven, Bird, Billingsley, Wang, Rao, Hutchings, Jouvin, Putney, Kinet: Defective mast cell effector functions in mice lacking the CRACM1 pore subunit of store-operated calcium release-activated calcium channels. in Nature immunology 2007
Human Monoclonal ORAI1 Primary Antibody for ELISA, ICC - ABIN4341596
Ávila-Medina, Calderón-Sánchez, González-Rodríguez, Monje-Quiroga, Rosado, Castellano, Ordóñez, Smani: Orai1 and TRPC1 Proteins Co-localize with CaV1.2 Channels to Form a Signal Complex in Vascular Smooth Muscle Cells. in The Journal of biological chemistry 2016
Horse (Equine) Polyclonal ORAI1 Primary Antibody for WB - ABIN2784057
Peel, Liu, Hall: ORAI and store-operated calcium influx in human airway smooth muscle cells. in American journal of respiratory cell and molecular biology 2008
Orai1 is localized to the cleavage furrow during cytokinesis of the first and second cell division cycles in zebrafish embryos.
The findings identify ORAI1 as an important regulator of cardiac and skeletal muscle function and provide evidence linking ORAI1-mediated calcium signaling to sarcomere integrity and cardiomyocyte function.
The Orai1 actively recycles between an endosomal compartment and the cell membrane through a Rho-dependent endocytic pathway.
STIM1 (show STIM1 Antibodies) and Orai1 are essential components of the signal transduction cascade that regulates sex pheromone production.
CRAC channel functions as a hexamer of Orai1 subunits
A novel heterozygous c.290C>G (p.S97C) mutation in ORAI1 causing a mild- and late-onset tubular aggregate myopathy and congenital miosis via constitutive activation of the CRAC channel.
What is less clear is how the spatial and temporal spread of intracellular Ca(2 (show CA2 Antibodies)+) is shaped and regulated by differential expression of the individual SOCE genes and their splice variants, their heteromeric combinations and pre- and posttranslational modifications. This review focuses on principle mechanisms regulating expression, splicing, and targeting of Ca(2 (show CA2 Antibodies)+) release-activated Ca(2 (show CA2 Antibodies)+) (CRAC) channels.
The focus is on the activation of the STIM proteins, the subsequent coupling of STIM1 (show STIM1 Antibodies) to Orai1, and the consequent structural rearrangements that gate the Orai channels into the open state to allow Ca(2 (show CA2 Antibodies)+)permeation into the cell. [review]
results argue strongly against a tetrameric configuration for Orai1 channels and indicate that the Orai1 channel functions as a hexamer.
APP (show APP Antibodies) does not modulate Orai-dependent store-operated calcium entry following quantitative calcium store depletion.
Orai1 regulates osteogenic differentiation through BMP signaling, and the Orai1-BMP signaling may be a possible therapeutic target for treating bone-related diseases.
Orai1-mediated Ca(2 (show CA2 Antibodies)+)-influx and SPCA2 (show ATP2C2 Antibodies)-mediated Ca(2 (show CA2 Antibodies)+) uptake activity into the Golgi/secretory pathway might be coupled possibly in a microdomain. This channel/pump complex may efficiently transfer Ca(2 (show CA2 Antibodies)+) into the secretory pathway, which might play a role in SPCA2 (show ATP2C2 Antibodies)-expressing secretory cells, such as mammary gland during lactation.
This study may lay the foundation for finding novel lead compounds for clinical trials that could positively modulate the course of autoimmune disorders with ORAI1 as its specific target.
Mutations in the STIM1 (show STIM1 Antibodies) and ORAI1 genes cause calcium dyshomeostasis in tubular aggregate myopathy. (Review)
these data indicate for the first time a functional interaction between Orai1 (show TMEM132A Antibodies), TRPC1 (show TRPC1 Antibodies), and CaV1.2 (show CACNA1C Antibodies) channels in Vascular Smooth Muscle Cells, confirming that upon agonist stimulation, vessel contraction involves Ca(2 (show CA2 Antibodies)+) entry due to co-activation of Orai1 (show TMEM132A Antibodies)- and TRPC1 (show TRPC1 Antibodies)-dependent store-operated Ca(2 (show CA2 Antibodies)+) channels and L-type Ca(2 (show CA2 Antibodies)+) channels.
reveal that Orai1 (show TMEM132A Antibodies)(-/-) male mice are sterile and have severe defects in spermatogenesis, with prominent deficiencies in mid- to late-stage elongating spermatid development
In Dicer (show DICER1 Antibodies)-deficient mice Orai1 (show TMEM132A Antibodies) was down-regulated at mRNA and protein level in CD4 (show CD4 Antibodies)+ T cells.
results identified the ORAI-NOX2 (show CYBB Antibodies) feedback loop as a determinant of monocyte immune responses.
Orai1 (show TMEM132A Antibodies)-dependent Ca(2 (show CA2 Antibodies)+) entry promotes atherogenesis possibly by promoting foam cell formation and vascular inflammation, rendering orai1 (show TMEM132A Antibodies) Ca(2 (show CA2 Antibodies)+) channel a potential therapeutic target against atherosclerosis.
alternative translation initiation of the Orai1 (show TMEM132A Antibodies) message produces at least three types of Ca(2 (show CA2 Antibodies)+) channels with distinct signaling and regulatory properties.
Orai1 (show TMEM132A Antibodies) and STIM1 (show STIM1 Antibodies) have roles in inhibiting matrix protein expression
SOCE blockers or ablation of STIM1 (show STIM1 Antibodies), STIM2 (show Stim2 Antibodies), or Orai1 (show TMEM132A Antibodies) severely impaired nucleotide-induced migration and phagocytosis in microglia.
Our data establish Orai1 (show TMEM132A Antibodies) as key signal mediator of C5aR (show C5AR1 Antibodies) activation, contributing to inflammation
Orai1 (show TMEM132A Antibodies) store-operated calcium channels have an essential role in lactation
The protein encoded by this gene is a membrane calcium channel subunit that is activated by the calcium sensor STIM1 when calcium stores are depleted. This type of channel is the primary way for calcium influx into T-cells. Defects in this gene are a cause of immune dysfunction with T-cell inactivation due to calcium entry defect type 1 (IDTICED1).
ORAI calcium release-activated calcium modulator 1
, calcium release-activated calcium channel protein 1
, protein orai-1
, transmembrane protein 142A
, protein orai-2
, transmembrane protein 142B
, calcium release-activated calcium modulator 1
, calcium release-activated calcium channel 1