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The protein encoded by ORAI1 is a membrane calcium channel subunit that is activated by the calcium sensor STIM1 when calcium stores are depleted. Additionally we are shipping ORAI1 Kits (4) and and many more products for this protein.
Showing 10 out of 127 products:
Human Polyclonal ORAI1 Primary Antibody for WB - ABIN658509
Feng, Grice, Faddy, Nguyen, Leitch, Wang, Muend, Kenny, Sukumar, Roberts-Thomson, Monteith, Rao: Store-independent activation of Orai1 by SPCA2 in mammary tumors. in Cell 2010
Show all 4 references for ABIN658509
Human Polyclonal ORAI1 Primary Antibody for EIA, IHC (p) - ABIN953931
Calloway, Holowka, Baird: A basic sequence in STIM1 promotes Ca2+ influx by interacting with the C-terminal acidic coiled coil of Orai1. in Biochemistry 2010
Show all 3 references for ABIN953931
Human Polyclonal ORAI1 Primary Antibody for IHC (p), WB - ABIN318921
Lewis: Calcium signaling mechanisms in T lymphocytes. in Annual review of immunology 2001
Show all 2 references for ABIN318921
Human Polyclonal ORAI1 Primary Antibody for WB - ABIN375074
Vig, DeHaven, Bird, Billingsley, Wang, Rao, Hutchings, Jouvin, Putney, Kinet: Defective mast cell effector functions in mice lacking the CRACM1 pore subunit of store-operated calcium release-activated calcium channels. in Nature immunology 2007
Human Monoclonal ORAI1 Primary Antibody for ELISA, ICC - ABIN4341596
Ávila-Medina, Calderón-Sánchez, González-Rodríguez, Monje-Quiroga, Rosado, Castellano, Ordóñez, Smani: Orai1 and TRPC1 Proteins Co-localize with CaV1.2 Channels to Form a Signal Complex in Vascular Smooth Muscle Cells. in The Journal of biological chemistry 2016
Human Polyclonal ORAI1 Primary Antibody for WB - ABIN2784057
Peel, Liu, Hall: ORAI and store-operated calcium influx in human airway smooth muscle cells. in American journal of respiratory cell and molecular biology 2008
Orai1 is localized to the cleavage furrow during cytokinesis of the first and second cell division cycles in zebrafish embryos.
The findings identify ORAI1 as an important regulator of cardiac and skeletal muscle function and provide evidence linking ORAI1-mediated calcium signaling to sarcomere integrity and cardiomyocyte function.
The Orai1 actively recycles between an endosomal compartment and the cell membrane through a Rho-dependent endocytic pathway.
STIM1 (show STIM1 Antibodies) and Orai1 are essential components of the signal transduction cascade that regulates sex pheromone production.
Orai1-mediated Ca(2 (show CA2 Antibodies)+)-influx and SPCA2 (show ATP2C2 Antibodies)-mediated Ca(2 (show CA2 Antibodies)+) uptake activity into the Golgi/secretory pathway might be coupled possibly in a microdomain. This channel/pump complex may efficiently transfer Ca(2 (show CA2 Antibodies)+) into the secretory pathway, which might play a role in SPCA2 (show ATP2C2 Antibodies)-expressing secretory cells, such as mammary gland during lactation.
This study may lay the foundation for finding novel lead compounds for clinical trials that could positively modulate the course of autoimmune disorders with ORAI1 as its specific target.
Mutations in the STIM1 (show STIM1 Antibodies) and ORAI1 genes cause calcium dyshomeostasis in tubular aggregate myopathy. (Review)
Results revealed that Orai1-mediated store-operated Ca(2 (show CA2 Antibodies)+) entry is critical for gastrointestinal stromal tumor cell proliferation via c-KIT (show KIT Antibodies) and ERK (show EPHB2 Antibodies) signaling pathway activation.
SARAF (show TMEM66 Antibodies) overexpression attenuated store operated Ca2 (show CA2 Antibodies)+ entry and the STIM1 (show STIM1 Antibodies)-Orai1 interaction in cells endogenously expressing STIM1 (show STIM1 Antibodies) and Orai1 while RNAi-mediated SARAF (show TMEM66 Antibodies) silencing induced opposite effects.
the STIM1 (show STIM1 Antibodies)-Orai1 system has a role in intra-cellular calcium elevation induced by ATP in cultured human keratinocytes
Chorein (show VPS13A Antibodies) is a stimulator of Orai1 expression and thus of store operated Ca2 (show CA2 Antibodies)+ entry.
Coupling of the endoplasmic reticulum (ER) Ca(2 (show CA2 Antibodies)+)sensor, stromal interaction molecule 1 (STIM1 (show STIM1 Antibodies)), to the Ca(2 (show CA2 Antibodies)+)-selective channel, Orai1, is regulated by these elements and depends on membrane organization, both at the plasma membrane and at the ER
Decreased Orai1 expression was observed in human term-pregnant laboring myometrium compared with non-pregnant myometrium.
identified a Ca(2 (show CA2 Antibodies)+)-accumulating region (CAR) in the extracellular opening of Orai1, which explains how concentrating Ca(2 (show CA2 Antibodies)+) at the mouth of Orai1 facilitates channel permeation and contributes to selectivity.
reveal that Orai1 (show TMEM132A Antibodies)(-/-) male mice are sterile and have severe defects in spermatogenesis, with prominent deficiencies in mid- to late-stage elongating spermatid development
In Dicer (show DICER1 Antibodies)-deficient mice Orai1 (show TMEM132A Antibodies) was down-regulated at mRNA and protein level in CD4 (show CD4 Antibodies)+ T cells.
results identified the ORAI-NOX2 (show CYBB Antibodies) feedback loop as a determinant of monocyte immune responses.
Orai1 (show TMEM132A Antibodies)-dependent Ca(2 (show CA2 Antibodies)+) entry promotes atherogenesis possibly by promoting foam cell formation and vascular inflammation, rendering orai1 (show TMEM132A Antibodies) Ca(2 (show CA2 Antibodies)+) channel a potential therapeutic target against atherosclerosis.
alternative translation initiation of the Orai1 (show TMEM132A Antibodies) message produces at least three types of Ca(2 (show CA2 Antibodies)+) channels with distinct signaling and regulatory properties.
Orai1 (show TMEM132A Antibodies) and STIM1 (show STIM1 Antibodies) have roles in inhibiting matrix protein expression
SOCE blockers or ablation of STIM1 (show STIM1 Antibodies), STIM2 (show Stim2 Antibodies), or Orai1 (show TMEM132A Antibodies) severely impaired nucleotide-induced migration and phagocytosis in microglia.
Our data establish Orai1 (show TMEM132A Antibodies) as key signal mediator of C5aR (show C5AR1 Antibodies) activation, contributing to inflammation
Orai1 (show TMEM132A Antibodies) store-operated calcium channels have an essential role in lactation
TRPC6 (show TRPC6 Antibodies) activity can occur independently of the physical interaction with Orai1 (show TMEM132A Antibodies)
The protein encoded by this gene is a membrane calcium channel subunit that is activated by the calcium sensor STIM1 when calcium stores are depleted. This type of channel is the primary way for calcium influx into T-cells. Defects in this gene are a cause of immune dysfunction with T-cell inactivation due to calcium entry defect type 1 (IDTICED1).
ORAI calcium release-activated calcium modulator 1
, calcium release-activated calcium channel protein 1
, protein orai-1
, transmembrane protein 142A
, protein orai-2
, transmembrane protein 142B
, calcium release-activated calcium modulator 1
, calcium release-activated calcium channel 1