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The protein encoded by ORAI1 is a membrane calcium channel subunit that is activated by the calcium sensor STIM1 when calcium stores are depleted. Additionally we are shipping ORAI1 Kits (4) and and many more products for this protein.
Showing 10 out of 118 products:
Human Polyclonal ORAI1 Primary Antibody for WB - ABIN658509
Feng, Grice, Faddy, Nguyen, Leitch, Wang, Muend, Kenny, Sukumar, Roberts-Thomson, Monteith, Rao: Store-independent activation of Orai1 by SPCA2 in mammary tumors. in Cell 2010
Show all 4 references for 658509
Human Polyclonal ORAI1 Primary Antibody for EIA, IHC (p) - ABIN953931
Calloway, Holowka, Baird: A basic sequence in STIM1 promotes Ca2+ influx by interacting with the C-terminal acidic coiled coil of Orai1. in Biochemistry 2010
Show all 3 references for 953931
Human Polyclonal ORAI1 Primary Antibody for ELISA, WB - ABIN449577
Li, Lu, Xu, Xie, Chen, Xu: Mapping the interacting domains of STIM1 and Orai1 in Ca2+ release-activated Ca2+ channel activation. in The Journal of biological chemistry 2007
Show all 2 references for 449577
Human Polyclonal ORAI1 Primary Antibody for IHC (p), WB - ABIN318921
Lewis: Calcium signaling mechanisms in T lymphocytes. in Annual review of immunology 2001
Show all 2 references for 318921
Cow (Bovine) Polyclonal ORAI1 Primary Antibody for WB - ABIN2784058
Peel, Liu, Hall: ORAI and store-operated calcium influx in human airway smooth muscle cells. in American journal of respiratory cell and molecular biology 2008
Human Monoclonal ORAI1 Primary Antibody for ELISA, ICC - ABIN4341596
Ávila-Medina, Calderón-Sánchez, González-Rodríguez, Monje-Quiroga, Rosado, Castellano, Ordóñez, Smani: Orai1 and TRPC1 Proteins Co-localize with CaV1.2 Channels to Form a Signal Complex in Vascular Smooth Muscle Cells. in The Journal of biological chemistry 2016
Human Polyclonal ORAI1 Primary Antibody for ELISA, WB - ABIN334452
Vig, DeHaven, Bird, Billingsley, Wang, Rao, Hutchings, Jouvin, Putney, Kinet: Defective mast cell effector functions in mice lacking the CRACM1 pore subunit of store-operated calcium release-activated calcium channels. in Nature immunology 2007
Orai1 is localized to the cleavage furrow during cytokinesis of the first and second cell division cycles in zebrafish embryos.
The findings identify ORAI1 as an important regulator of cardiac and skeletal muscle function and provide evidence linking ORAI1-mediated calcium signaling to sarcomere integrity and cardiomyocyte function.
The Orai1 actively recycles between an endosomal compartment and the cell membrane through a Rho-dependent endocytic pathway.
STIM1 (show STIM1 Antibodies) and Orai1 are essential components of the signal transduction cascade that regulates sex pheromone production.
RASSF4 (show RIN2 Antibodies) controls store operated calcium entry and endoplasmic reticulum-plasma membrane junctions through ARF6 (show ARF6 Antibodies)-dependent regulation of PM PI(4,5)P2 levels, pivotal for a variety of physiological processes.
findings provide evidence for a role for Orai1 and Orai2 (show ORAI2 Antibodies), in SOCE and migration in the human HL60 promyeloblastic cell line
findings demonstrate that Ca2 (show CA2 Antibodies)+ influx via store-operated CRAC channels is essential for CaCC (show CLCA1 Antibodies) activation, chloride secretion, and sweat production in humans and mice.
F. vulgare fruits extract and its hexane fraction strongly blocked ORAI1 currents and tyrosinase (show TYR Antibodies) activity and significantly inhibited UV-induced melanogenesis
Aptamer Y1 binds to Orai1 and inhibits Ca2 (show CA2 Antibodies)+ influx into antigen-activated mast cells
Elevated Orai1 and STIM1 (show STIM1 Antibodies) expressions upregulate MACC1 (show MACC1 Antibodies) expression to promote tumor cell proliferation, metabolism, migration, and invasion in human gastric cancer.
Orai1 expression was higher in colorectal cancer (CRC (show CALR Antibodies)) tissues than adjacent non-cancerous tissues; increased expression of Orai1 was observed in invasive CRC (show CALR Antibodies) cell lines and ectopic expression of Orai1 enhanced cell proliferation and inhibited apoptosis; the Akt (show AKT1 Antibodies)/GSK3beta (show GSK3b Antibodies) pathway contributed to Orai1 effects in CRC (show CALR Antibodies) cells, and Orai1 was a direct target of miR (show MLXIP Antibodies)-519
Store-operated Ca(2 (show CA2 Antibodies)+) entry activates a mitochondrial redox transient which is dependent on NCLX (show SLC24A6 Antibodies) and is required for preventing Orai1 inactivation through oxidation of a critical cysteine (Cys195) in the third transmembrane helix of Orai1.
CRAC channel functions as a hexamer of Orai1 subunits
A novel heterozygous c.290C>G (p.S97C) mutation in ORAI1 causing a mild- and late-onset tubular aggregate myopathy and congenital miosis via constitutive activation of the CRAC channel.
Mouse embryos deficient in Orai1 (show TMEM132A Antibodies), Klf2 (show KLF2 Antibodies), or Klf4 (show KLF4 Antibodies) showed a significantly reduced lymphatic density and impaired lymphatic development.
Store operated calcium entry negatively regulates the Smad1 (show SMAD1 Antibodies) signaling pathway and inhibits Col (show HDAC1 Antibodies) IV protein production in glomerular mesangial cells.
F. vulgare fruits extract and its hexane fraction strongly blocked ORAI1 (show TMEM132A Antibodies) currents and tyrosinase (show TYR Antibodies) activity and significantly inhibited UV-induced melanogenesis
mice lacking acinar Orai1 (show TMEM132A Antibodies) exhibited intestinal bacterial outgrowth and dysbiosis, ultimately causing systemic translocation, inflammation, and death.
these data indicate for the first time a functional interaction between Orai1 (show TMEM132A Antibodies), TRPC1 (show TRPC1 Antibodies), and CaV1.2 (show CACNA1C Antibodies) channels in Vascular Smooth Muscle Cells, confirming that upon agonist stimulation, vessel contraction involves Ca(2 (show CA2 Antibodies)+) entry due to co-activation of Orai1 (show TMEM132A Antibodies)- and TRPC1 (show TRPC1 Antibodies)-dependent store-operated Ca(2 (show CA2 Antibodies)+) channels and L-type Ca(2 (show CA2 Antibodies)+) channels.
reveal that Orai1 (show TMEM132A Antibodies)(-/-) male mice are sterile and have severe defects in spermatogenesis, with prominent deficiencies in mid- to late-stage elongating spermatid development
In Dicer (show DICER1 Antibodies)-deficient mice Orai1 (show TMEM132A Antibodies) was down-regulated at mRNA and protein level in CD4 (show CD4 Antibodies)+ T cells.
results identified the ORAI-NOX2 (show CYBB Antibodies) feedback loop as a determinant of monocyte immune responses.
Orai1 (show TMEM132A Antibodies)-dependent Ca(2 (show CA2 Antibodies)+) entry promotes atherogenesis possibly by promoting foam cell formation and vascular inflammation, rendering orai1 (show TMEM132A Antibodies) Ca(2 (show CA2 Antibodies)+) channel a potential therapeutic target against atherosclerosis.
The protein encoded by this gene is a membrane calcium channel subunit that is activated by the calcium sensor STIM1 when calcium stores are depleted. This type of channel is the primary way for calcium influx into T-cells. Defects in this gene are a cause of immune dysfunction with T-cell inactivation due to calcium entry defect type 1 (IDTICED1).
ORAI calcium release-activated calcium modulator 1
, calcium release-activated calcium channel protein 1
, protein orai-1
, transmembrane protein 142A
, protein orai-2
, transmembrane protein 142B
, calcium release-activated calcium modulator 1
, calcium release-activated calcium channel 1