anti-ORAI Calcium Release-Activated Calcium Modulator 1 (ORAI1) Antibodies

The protein encoded by ORAI1 is a membrane calcium channel subunit that is activated by the calcium sensor STIM1 when calcium stores are depleted. Additionally we are shipping ORAI1 Kits (4) and and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
ORAI1 84876 Q96D31
ORAI1 109305 Q8BWG9
ORAI1 304496 Q5M848
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Top anti-ORAI1 Antibodies at antibodies-online.com

Showing 10 out of 118 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Horse Rabbit Un-conjugated WB WB Suggested Anti-ORAI1 Antibody Titration: 0.2-1 ug/mlPositive Control: HepG2 cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-ORAI1 Antibody Titration: 0.2-1 ug/mlPositive Control: HepG2 cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated WB ORAI1 Antibody (C-term) (ABIN658509) western blot analysis in A375 cell line lysates (35 µg/lane). This demonstrates the ORAI1 antibody detected the ORAI1 protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB Formalin-fixed and paraffin-embedded human prostate carcinoma reacted with ORAI1 Antibody (Center) followed which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. Western blot analysis of ORAI1 Antibody (Center) in A375 cell line and mouse testis tissue lysates (35ug/lane). ORAI1 (arrow) was detected using the purified Pab. 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated IHC (p), WB 0.1 mg Log in to see 6 to 8 Days
$434.50
Details
Human Goat Un-conjugated ELISA, WB ABIN334452 (0.03µg/ml) staining of Human Placenta lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 100 μg Log in to see 6 to 7 Days
$326.89
Details
Human Mouse Un-conjugated ELISA, ICC, IF, IHC, IHC (p), WB Immunohistochemistry: Orai1 Antibody (3F6H5) [NBP1-75522] - ORAI1 in human spleen tissue with ORAI1 antibody at 2.5 ug/mL Western Blot: Orai1 Antibody (3F6H5) [NBP1-75522] - analysis of ORAI1 in human ovary tissue lysate with ORAI1 antibody at (A) 1 and (B) 2 ug/mL. 0.1 mg Log in to see 8 to 11 Days
$447.56
Details
Human Goat Un-conjugated ELISA, WB 0.1 mg Log in to see 7 to 9 Days
$408.19
Details
Human Rabbit Un-conjugated WB Anti- Orai1 antibody, Western blotting All lanes: Anti Orai1  at 0.5ug/ml WB: SKOV Whole Cell Lysate at 40ug Predicted bind size: 33KD Observed bind size: 50KD 100 μg Log in to see 4 to 6 Days
$200.00
Details
Human Rabbit Un-conjugated IHC (p), WB Formalin-fixed and paraffin-embedded human prostate carcinoma reacted with ORAI1 Antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. Western blot analysis of ORAI1 Antibody (Center) (ABIN653318) in A375 cell line and mouse testis tissue lysates (35 µg/lane). ORAI1 (arrow) was detected using the purified polyclonal antibody. 400 μL Log in to see 10 to 11 Days
$324.50
Details

ORAI1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-ORAI1 Antibodies

  1. Human Polyclonal ORAI1 Primary Antibody for WB - ABIN658509 : Feng, Grice, Faddy, Nguyen, Leitch, Wang, Muend, Kenny, Sukumar, Roberts-Thomson, Monteith, Rao: Store-independent activation of Orai1 by SPCA2 in mammary tumors. in Cell 2010 (PubMed)
    Show all 4 references for 658509

  2. Human Polyclonal ORAI1 Primary Antibody for EIA, IHC (p) - ABIN953931 : Calloway, Holowka, Baird: A basic sequence in STIM1 promotes Ca2+ influx by interacting with the C-terminal acidic coiled coil of Orai1. in Biochemistry 2010 (PubMed)
    Show all 3 references for 953931

  3. Human Polyclonal ORAI1 Primary Antibody for ELISA, WB - ABIN449577 : Li, Lu, Xu, Xie, Chen, Xu: Mapping the interacting domains of STIM1 and Orai1 in Ca2+ release-activated Ca2+ channel activation. in The Journal of biological chemistry 2007 (PubMed)
    Show all 2 references for 449577

  4. Human Polyclonal ORAI1 Primary Antibody for IHC (p), WB - ABIN318921 : Lewis: Calcium signaling mechanisms in T lymphocytes. in Annual review of immunology 2001 (PubMed)
    Show all 2 references for 318921

  5. Cow (Bovine) Polyclonal ORAI1 Primary Antibody for WB - ABIN2784058 : Peel, Liu, Hall: ORAI and store-operated calcium influx in human airway smooth muscle cells. in American journal of respiratory cell and molecular biology 2008 (PubMed)

  6. Human Monoclonal ORAI1 Primary Antibody for ELISA, ICC - ABIN4341596 : Ávila-Medina, Calderón-Sánchez, González-Rodríguez, Monje-Quiroga, Rosado, Castellano, Ordóñez, Smani: Orai1 and TRPC1 Proteins Co-localize with CaV1.2 Channels to Form a Signal Complex in Vascular Smooth Muscle Cells. in The Journal of biological chemistry 2016 (PubMed)

  7. Human Polyclonal ORAI1 Primary Antibody for ELISA, WB - ABIN334452 : Vig, DeHaven, Bird, Billingsley, Wang, Rao, Hutchings, Jouvin, Putney, Kinet: Defective mast cell effector functions in mice lacking the CRACM1 pore subunit of store-operated calcium release-activated calcium channels. in Nature immunology 2007 (PubMed)

More Antibodies against ORAI1 Interaction Partners

Zebrafish ORAI Calcium Release-Activated Calcium Modulator 1 (ORAI1) interaction partners

  1. Orai1 is localized to the cleavage furrow during cytokinesis of the first and second cell division cycles in zebrafish embryos.

  2. The findings identify ORAI1 as an important regulator of cardiac and skeletal muscle function and provide evidence linking ORAI1-mediated calcium signaling to sarcomere integrity and cardiomyocyte function.

Xenopus laevis ORAI Calcium Release-Activated Calcium Modulator 1 (ORAI1) interaction partners

  1. The Orai1 actively recycles between an endosomal compartment and the cell membrane through a Rho-dependent endocytic pathway.

Silk Worm ORAI Calcium Release-Activated Calcium Modulator 1 (ORAI1) interaction partners

  1. STIM1 (show STIM1 Antibodies) and Orai1 are essential components of the signal transduction cascade that regulates sex pheromone production.

Human ORAI Calcium Release-Activated Calcium Modulator 1 (ORAI1) interaction partners

  1. RASSF4 (show RIN2 Antibodies) controls store operated calcium entry and endoplasmic reticulum-plasma membrane junctions through ARF6 (show ARF6 Antibodies)-dependent regulation of PM PI(4,5)P2 levels, pivotal for a variety of physiological processes.

  2. findings provide evidence for a role for Orai1 and Orai2 (show ORAI2 Antibodies), in SOCE and migration in the human HL60 promyeloblastic cell line

  3. findings demonstrate that Ca2 (show CA2 Antibodies)+ influx via store-operated CRAC channels is essential for CaCC (show CLCA1 Antibodies) activation, chloride secretion, and sweat production in humans and mice.

  4. F. vulgare fruits extract and its hexane fraction strongly blocked ORAI1 currents and tyrosinase (show TYR Antibodies) activity and significantly inhibited UV-induced melanogenesis

  5. Aptamer Y1 binds to Orai1 and inhibits Ca2 (show CA2 Antibodies)+ influx into antigen-activated mast cells

  6. Elevated Orai1 and STIM1 (show STIM1 Antibodies) expressions upregulate MACC1 (show MACC1 Antibodies) expression to promote tumor cell proliferation, metabolism, migration, and invasion in human gastric cancer.

  7. Orai1 expression was higher in colorectal cancer (CRC (show CALR Antibodies)) tissues than adjacent non-cancerous tissues; increased expression of Orai1 was observed in invasive CRC (show CALR Antibodies) cell lines and ectopic expression of Orai1 enhanced cell proliferation and inhibited apoptosis; the Akt (show AKT1 Antibodies)/GSK3beta (show GSK3b Antibodies) pathway contributed to Orai1 effects in CRC (show CALR Antibodies) cells, and Orai1 was a direct target of miR (show MLXIP Antibodies)-519

  8. Store-operated Ca(2 (show CA2 Antibodies)+) entry activates a mitochondrial redox transient which is dependent on NCLX (show SLC24A6 Antibodies) and is required for preventing Orai1 inactivation through oxidation of a critical cysteine (Cys195) in the third transmembrane helix of Orai1.

  9. CRAC channel functions as a hexamer of Orai1 subunits

  10. A novel heterozygous c.290C>G (p.S97C) mutation in ORAI1 causing a mild- and late-onset tubular aggregate myopathy and congenital miosis via constitutive activation of the CRAC channel.

Mouse (Murine) ORAI Calcium Release-Activated Calcium Modulator 1 (ORAI1) interaction partners

  1. findings demonstrate that Ca2 (show CA2 Antibodies)+ influx via store-operated CRAC channels is essential for CaCC (show CLCA1 Antibodies) activation, chloride secretion, and sweat production in humans and mice.

  2. Mouse embryos deficient in Orai1 (show TMEM132A Antibodies), Klf2 (show KLF2 Antibodies), or Klf4 (show KLF4 Antibodies) showed a significantly reduced lymphatic density and impaired lymphatic development.

  3. Store operated calcium entry negatively regulates the Smad1 (show SMAD1 Antibodies) signaling pathway and inhibits Col (show HDAC1 Antibodies) IV protein production in glomerular mesangial cells.

  4. F. vulgare fruits extract and its hexane fraction strongly blocked ORAI1 (show TMEM132A Antibodies) currents and tyrosinase (show TYR Antibodies) activity and significantly inhibited UV-induced melanogenesis

  5. mice lacking acinar Orai1 (show TMEM132A Antibodies) exhibited intestinal bacterial outgrowth and dysbiosis, ultimately causing systemic translocation, inflammation, and death.

  6. these data indicate for the first time a functional interaction between Orai1 (show TMEM132A Antibodies), TRPC1 (show TRPC1 Antibodies), and CaV1.2 (show CACNA1C Antibodies) channels in Vascular Smooth Muscle Cells, confirming that upon agonist stimulation, vessel contraction involves Ca(2 (show CA2 Antibodies)+) entry due to co-activation of Orai1 (show TMEM132A Antibodies)- and TRPC1 (show TRPC1 Antibodies)-dependent store-operated Ca(2 (show CA2 Antibodies)+) channels and L-type Ca(2 (show CA2 Antibodies)+) channels.

  7. reveal that Orai1 (show TMEM132A Antibodies)(-/-) male mice are sterile and have severe defects in spermatogenesis, with prominent deficiencies in mid- to late-stage elongating spermatid development

  8. In Dicer (show DICER1 Antibodies)-deficient mice Orai1 (show TMEM132A Antibodies) was down-regulated at mRNA and protein level in CD4 (show CD4 Antibodies)+ T cells.

  9. results identified the ORAI-NOX2 (show CYBB Antibodies) feedback loop as a determinant of monocyte immune responses.

  10. Orai1 (show TMEM132A Antibodies)-dependent Ca(2 (show CA2 Antibodies)+) entry promotes atherogenesis possibly by promoting foam cell formation and vascular inflammation, rendering orai1 (show TMEM132A Antibodies) Ca(2 (show CA2 Antibodies)+) channel a potential therapeutic target against atherosclerosis.

ORAI1 Antigen Profile

Protein Summary

The protein encoded by this gene is a membrane calcium channel subunit that is activated by the calcium sensor STIM1 when calcium stores are depleted. This type of channel is the primary way for calcium influx into T-cells. Defects in this gene are a cause of immune dysfunction with T-cell inactivation due to calcium entry defect type 1 (IDTICED1).

Gene names and symbols associated with ORAI1

  • ORAI calcium release-activated calcium modulator 1b (orai1b) antibody
  • ORAI calcium release-activated calcium modulator 1 (orai1) antibody
  • ORAI calcium release-activated calcium modulator 1 (ORAI1) antibody
  • ORAI calcium release-activated calcium modulator 1 (Orai1) antibody
  • ORAI calcium release-activated calcium modulator 1 (LOC100218031) antibody
  • ORAI calcium release-activated calcium modulator 2 (orai2) antibody
  • CRACM1 antibody
  • D730049H07Rik antibody
  • im:7146264 antibody
  • LOC100218031 antibody
  • orai-1 antibody
  • ORAI1 antibody
  • orai2 antibody
  • ORAT1 antibody
  • RGD1311873 antibody
  • Tmem142a antibody
  • tmem142b antibody
  • zgc:109721 antibody

Protein level used designations for ORAI1

ORAI calcium release-activated calcium modulator 1 , calcium release-activated calcium channel protein 1 , protein orai-1 , transmembrane protein 142A , protein orai-2 , transmembrane protein 142B , calcium release-activated calcium modulator 1 , calcium release-activated calcium channel 1

GENE ID SPECIES
402892 Danio rerio
403390 Xenopus laevis
473293 Pan troglodytes
700190 Macaca mulatta
100125061 Xenopus (Silurana) tropicalis
100188931 Bombyx mori
100218031 Taeniopygia guttata
84876 Homo sapiens
486261 Canis lupus familiaris
100154923 Sus scrofa
517688 Bos taurus
109305 Mus musculus
304496 Rattus norvegicus
416845 Gallus gallus
734537 Xenopus laevis
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